Equillium Stock Price, News & Analysis

Equillium, Inc. (Nasdaq: EQ) presented promising data on its multi-cytokine inhibitors, EQ101 and EQ102, at the La Jolla Immunology Conference. The research indicates that these inhibitors effectively reduce the activity of cytotoxic T lymphocytes and natural killer cells, which are pivotal in autoimmune diseases.

EQ101 and EQ102 demonstrated approximately 50% and 40% reductions in CD4 and CD8 T cell proliferation, respectively. The company plans to initiate a Phase 2 study for EQ101 in alopecia areata and a Phase 1 study for EQ102 in healthy volunteers by year-end 2022.

Equillium announced interim results from the EQUALISE study evaluating itolizumab in lupus nephritis patients. Of the 6 subjects evaluated, 83% achieved a complete or partial response, and 67% attained over 80% reduction in urine protein creatinine ratio (UPCR) by week 28. The treatment showed a favorable safety profile with no serious adverse events. The mean baseline UPCR was notably high at 5.8 g/g, and the study's results point to potential as a competitive therapy in a field where other treatments have fallen short.

Equillium, Inc. (Nasdaq: EQ) announces the acceptance of its abstract for presentation at ACR Convergence, the American College of Rheumatology’s annual meeting, set for November 10-14, 2022. The abstract, titled 'Urine ALCAM is a Strong Predictor of Lupus Nephritis', highlights urinary soluble ALCAM as a potential biomarker for disease severity in lupus nephritis. Equillium develops novel therapeutics targeting autoimmune disorders, including itolizumab, currently undergoing clinical trials for conditions like lupus nephritis and acute graft-versus-host disease.

Equillium will acquire Metacrine in an all-stock merger, strengthening its financial position with an additional $33 million in cash upon closing, expected to extend its operational runway into 2024. The acquisition includes the novel drug MET642, a Phase 2-ready FXR agonist for ulcerative colitis. Preston Klassen, CEO of Metacrine, will join Equillium's Board of Directors. The transaction is approved by both companies' boards and aims to enhance Equillium's clinical development efforts and market reach.

Equillium, a clinical-stage biotechnology company, announces participation in the Wells Fargo Healthcare Conference on September 7 and the H.C. Wainwright Annual Global Investment Conference on September 12. The company will provide insights into its clinical assets and upcoming milestones.

The Wells Fargo event will take place at Encore Boston Harbor at 1:20 PM PT, while the H.C. Wainwright event will be held at Lotte New York Palace Hotel at 12:00 PM PT. Webcast access will be available on Equillium's website.

Equillium, Inc. (Nasdaq: EQ) reported its Q2 2022 financial results, highlighting a net loss of $14.1 million, or $(0.41) per share, compared to a loss of $9.2 million in Q2 2021. R&D expenses rose to $9.5 million, up from $6.0 million, due to increased clinical development costs. G&A expenses also increased to $4.1 million from $2.9 million. The company is advancing its clinical studies, including initiating Phase 2 trials for EQ101 and EQ102 in alopecia areata and celiac disease, respectively. Cash reserves stood at $57.6 million, sufficient to support operations for at least 12 months.

Equillium, Inc. (Nasdaq: EQ) announced a presentation at the 3rd Annual Cytokine-Based Drug Development Summit, showcasing its multi-cytokine inhibitor technology. Dr. Stephen Connelly presented data on EQ101, a tri-specific cytokine inhibitor targeting IL-2, IL-9, and IL-15, which has shown promise in treating inflammatory and neoplastic skin diseases. The company plans to initiate Phase 2 and Phase 1 studies for EQ101 and EQ102, respectively, by year's end. This innovative approach may allow for more selective targeting of cytokines compared to traditional JAK inhibitors.

Equillium, Inc. (Nasdaq: EQ), a clinical-stage biotechnology company, will present at the H.C. Wainwright Global Investment Conference on May 24, 2022, at Fontainebleau Miami Beach Hotel, and at the Jefferies Healthcare Conference on June 8, 2022, at Marriott Marquis, New York City. The company aims to provide updates on its clinical programs and will hold one-on-one meetings. Both presentations will be accessible via webcast, with archived replays available for 90 days. Equillium is focused on developing therapeutics for severe autoimmune disorders.

Equillium, Inc. (Nasdaq: EQ) has initiated the Phase 3 EQUATOR study of itolizumab for first-line acute graft-versus-host disease (aGVHD). The study aims to enroll up to 200 patients, assessing itolizumab's efficacy against a placebo. Equillium also acquired Bioniz Therapeutics, adding two first-in-class assets to its pipeline. First quarter 2022 financial results showed a net loss of $37.4 million or $(1.17) per share, up from a $9.0 million loss last year due to increased expenses. Cash and equivalents totaled $68.8 million as of March 31, 2022.