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Bayer and Evotec Collaborate to Advance Precision Cardiology

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Bayer and Evotec have updated their strategic collaboration to focus on developing innovative precision treatments for cardiovascular diseases. By leveraging Evotec's disease modelling capabilities using human induced pluripotent stem cells (iPSCs), the alliance aims to identify and validate novel targets to build a portfolio of precision cardiology therapeutics. Both companies will contribute drug targets and technology platforms for the development of innovative treatment options. Bayer will handle clinical development and commercialization while sharing responsibilities during pre-clinical development with Evotec. The collaboration seeks to address the high unmet medical need in cardiovascular diseases that are the leading cause of death globally.

Bayer ed Evotec hanno aggiornato la loro collaborazione strategica per concentrarsi sullo sviluppo di trattamenti innovativi e precisi per le malattie cardiovascolari. Sfruttando le capacità di modellazione della malattia di Evotec mediante l'uso di cellule staminali pluripotenti indotte umane (iPSC), l'alleanza mira a identificare e convalidare nuovi bersagli per costruire un portafoglio di terapie cardiologiche di precisione. Entrambe le aziende contribuiranno con bersagli farmacologici e piattaforme tecnologiche per lo sviluppo di opzioni di trattamento innovative. Bayer gestirà lo sviluppo clinico e la commercializzazione, condividendo le responsabilità durante lo sviluppo preclinico con Evotec. La collaborazione cerca di rispondere all'elevato bisogno medico non soddisfatto nelle malattie cardiovascolari, principale causa di morte a livello globale.
Bayer y Evotec han actualizado su colaboración estratégica para centrarse en el desarrollo de tratamientos de precisión innovadores para enfermedades cardiovasculares. Utilizando las capacidades de Evotec en modelado de enfermedades con células madre pluripotentes inducidas humanas (iPSC), la alianza tiene como objetivo identificar y validar nuevos objetivos para crear un portafolio de terapias cardiológicas de precisión. Ambas compañías contribuirán con objetivos farmacológicos y plataformas tecnológicas para el desarrollo de opciones de tratamiento innovadoras. Bayer se encargará del desarrollo clínico y de la comercialización, compartiendo responsabilidades durante el desarrollo preclínico con Evotec. La colaboración busca atender la alta necesidad médica no cubierta en enfermedades cardiovasculares, que son la principal causa de muerte a nivel mundial.
Bayer et Evotec ont mis à jour leur collaboration stratégique pour se concentrer sur le développement de traitements de précision innovants pour les maladies cardiovasculaires. En exploitant les capacités de modélisation des maladies d'Evotec utilisant des cellules souches pluripotentes induites humaines (iPSC), l'alliance vise à identifier et à valider de nouvelles cibles pour constituer un portefeuille de thérapeutiques cardiologiques de précision. Les deux entreprises contribueront avec des cibles médicamenteuses et des plateformes technologiques pour le développement d'options de traitement innovantes. Bayer gérera le développement clinique et la commercialisation, partageant les responsabilités pendant le développement préclinique avec Evotec. La collaboration cherche à répondre au besoin médical élevé non satisfait dans les maladies cardiovasculaires, principale cause de décès au niveau mondial.
Bayer und Evotec haben ihre strategische Zusammenarbeit aktualisiert, um sich auf die Entwicklung innovativer Präzisionsbehandlungen für Herz-Kreislauf-Erkrankungen zu konzentrieren. Indem sie Evotecs Fähigkeiten im Krankheitsmodellieren unter Verwendung von humanen induzierten pluripotenten Stammzellen (iPSCs) nutzen, zielt die Allianz darauf ab, neue Ziele zu identifizieren und zu validieren, um ein Portfolio von Präzisions-Kardiologie-Therapeutika aufzubauen. Beide Unternehmen werden sowohl Arzneimittelziele als auch Technologieplattformen für die Entwicklung innovativer Behandlungsoptionen beisteuern. Bayer wird die klinische Entwicklung und die Vermarktung übernehmen, während es die Verantwortung während der präklinischen Entwicklung mit Evotec teilt. Die Zusammenarbeit zielt darauf ab, den hohen ungedeckten medizinischen Bedarf bei Herz-Kreislauf-Erkrankungen, die weltweit die führende Todesursache sind, zu adressieren.
Positive
  • Bayer and Evotec are collaborating to develop innovative precision treatments for cardiovascular diseases, addressing a significant unmet medical need.

  • The use of human induced pluripotent stem cells (iPSCs) by Evotec provides unique opportunities to identify new disease mechanisms and pathways for novel treatments.

  • The strategic alliance between Bayer and Evotec aims to build a portfolio of precision cardiology therapeutics by leveraging Evotec's disease modelling capabilities.

Negative
  • No financial terms of the collaboration were disclosed in the press release.

  • While the collaboration is focused on developing innovative therapies, there is always a risk associated with the success of pre-clinical and clinical development stages.

  • BAYER AND EVOTEC UPDATE FOCUS OF THEIR COLLABORATION TO CARDIOVASCULAR DISEASES
  • STRATEGIC ALLIANCE LEVERAGES HUMAN INDUCED PLURIPOTENT STEM CELL DISEASE MODELLING FOR IDENTIFICATION OF NOVEL TARGETS
  • JOINT EFFORT AIMS TO DEVELOP INNOVATIVE THERAPIES IN PRECISION CARDIOLOGY

BERLIN AND HAMBURG, GERMANY / ACCESSWIRE / April 30, 2024 / Bayer and the German-based life science company, Evotec, announced today that they have updated the focus of their strategic collaboration to developing innovative precision treatments for cardiovascular diseases (CVDs).

The collaboration aims to identify and validate novel targets, with the goal of building a portfolio of precision cardiology therapeutics by leveraging Evotec's disease modelling capabilities using human induced pluripotent stem cells (iPSCs). iPSCs provide unique opportunities to identify new disease mechanisms and pathways for novel treatments.

Under the terms of the agreement, both companies will contribute drug targets and a comprehensive set of high-quality technology platforms for the development of innovative treatment options.

"This development takes our long-standing collaboration with Evotec to a new level, and has the added benefit of lessons learned from working together the past 12 years," said Juergen Eckhardt, M.D., Head of Business Development & Licensing at Bayer's Pharmaceuticals Division. "We remain committed to develop innovative therapies for patients in need and to tackle the high burden of cardiovascular disease."

"Cardiovascular diseases are the leading cause of death globally," said Dr Christian Rommel, Head of Research and Development at Bayer's Pharmaceuticals Division. "The refocused collaboration will leverage Evotec's industrialised iPSC-based disease modelling platform and Bayer's leadership in cardiology to advance a portfolio of innovative therapies for cardiovascular diseases with high unmet medical need. This complements our focus on disease areas where we can truly improve the standard of care by delivering superior therapeutic solutions to patients in need."

"In order to move the treatment paradigm beyond disease management, it is important to advance our understanding of the disease-relevant molecular mechanisms underlying cardiovascular diseases," said Dr Cord Dohrmann, Chief Scientific Officer of Evotec. "Our approach is based on highly validated disease models to identify novel targets and profile drug candidates more comprehensively for their efficacy and safety. Intervening with these disease-associated mechanisms more comprehensively will enable the development of more effective, disease modifying therapies with higher relevance for CVD to respond to the substantial unmet need associated with cardiovascular diseases."

Bayer and Evotec will share responsibilities during the pre-clinical development of potential clinical candidates. Bayer will be responsible for any subsequent clinical development and commercialisation.

No financial terms of the collaboration were disclosed.

ABOUT BAYER
Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. In line with its mission, "Health for all, Hunger for none," the company's products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2023, the Group employed around 100,000 people and had sales of 47.6 billion euros. R&D expenses before special items amounted to 5.8 billion euros. For more information, go to www.bayer.com .

Bayer Media Contact:
Lisa Hennig, phone +49 172 8693420
Email: lisa.hennig@bayer.com

ABOUT EVOTEC SE
Evotec is a life science company with a unique business model that delivers on its mission to discover and develop highly effective therapeutics and make them available to the patients. The Company's multimodality platform comprises a unique combination of innovative technologies, data and science for the discovery, development, and production of first-in-class and best-in-class pharmaceutical products. Evotec provides high value pipeline co-creating partnerships and solutions to all Top 20 Pharma and over 800 biotechnology companies, academic institutions, as well as other healthcare stakeholders. Evotec has strategic activities in a broad range of currently underserved therapeutic areas, including e.g. neurology, oncology, as well as metabolic and infectious diseases. Within these areas of expertise, Evotec aims to create the world-leading co-owned pipeline for innovative therapeutics and has to-date established a portfolio of more than 200 proprietary and co-owned R&D projects from early discovery to clinical development. Evotec operates globally with more than 5,000 highly qualified people. The Company's 17 sites offer highly synergistic technologies and services and operate as complementary clusters of excellence. For additional information please go to www.evotec.com and follow us on X/Twitter @Evotec and LinkedIn .

FORWARD-LOOKING STATEMENTS
This announcement contains forward-looking statements concerning future events, including the proposed offering and listing of Evotec's securities. Words such as "anticipate," "believe," "could," "estimate," "expect," "intend," "may," "might," "plan," "potential," "should," "target," "would" and variations of such words and similar expressions are intended to identify forward-looking statements. Such statements include comments regarding Evotec's expectations for revenues, Group EBITDA and unpartnered R&D expenses. These forward-looking statements are based on the information available to, and the expectations and assumptions deemed reasonable by Evotec at the time these statements were made. No assurance can be given that such expectations will prove to have been correct. These statements involve known and unknown risks and are based upon a number of assumptions and estimates, which are inherently subject to significant uncertainties and contingencies, many of which are beyond the control of Evotec. Evotec expressly disclaims any obligations or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Evotec's expectations with respect thereto or any change in events, conditions or circumstances on which any statement is based.

Media Contact Evotec SE:
Gabriele Hansen, SVP Head of Global Corporate Communications, Gabriele.Hansen@evotec.com
Hinnerk Rohwedder, Director of Global Corporate Communications, Hinnerk.Rohwedder@evotec.com

IR Contact Evotec SE:
Volker Braun, EVP Head of Global Investor Relations & ESG, Volker.Braun@evotec.com

SOURCE: Evotec SE



View the original press release on accesswire.com

FAQ

<p>What is the focus of the collaboration between Bayer and Evotec?</p>

The focus of the collaboration is to develop innovative precision treatments for cardiovascular diseases.

<p>What unique capabilities does Evotec bring to the collaboration?</p>

Evotec leverages human induced pluripotent stem cells (iPSCs) for disease modelling to identify new disease mechanisms and pathways for treatments.

<p>Who will handle clinical development and commercialization responsibilities in the collaboration?</p>

Bayer will be responsible for clinical development and commercialization, while both companies will share responsibilities during pre-clinical development.

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About EVO

Evotec SE is a publicly listed drug discovery and development company headquartered in Hamburg, Germany. The company operates globally, largely through external alliances with pharmaceutical and biotechnology companies, academic institutions, patient advocacy groups, and venture capitalists.