Welcome to our dedicated page for Fulcrum Therapeutics news (Ticker: FULC), a resource for investors and traders seeking the latest updates and insights on Fulcrum Therapeutics stock.
Fulcrum Therapeutics, Inc. (Nasdaq: FULC) is a clinical-stage biopharmaceutical company that reports frequent updates related to its work in genetically defined rare diseases. Company news regularly highlights progress for its lead program, pociredir, an investigational oral small molecule designed to increase fetal hemoglobin (HbF) for the treatment of sickle cell disease (SCD).
Investors and followers of FULC can expect news items covering clinical trial milestones, such as initial and updated data from the Phase 1b PIONEER trial of pociredir in adults with severe SCD. Fulcrum’s releases describe dose-escalation cohorts, changes in HbF levels, markers of hemolysis and anemia, and observations related to vaso-occlusive crises, along with safety and tolerability findings.
Fulcrum also issues corporate and financial announcements, including quarterly financial results, cash runway commentary, and details of public offerings of common stock and pre-funded warrants. Additional news may feature participation in major medical and investor conferences, such as the American Society of Hematology Annual Meeting and the J.P. Morgan Healthcare Conference, where the company presents clinical and preclinical data.
Other updates include disclosures on early-stage programs, such as calmodulin pathway modulators for bone marrow failure syndromes and preclinical data for EED inhibitor candidates in oncology models, as well as routine items like inducement stock option grants under Nasdaq Listing Rule 5635(c)(4). For readers tracking FULC, this news stream provides insight into the evolution of Fulcrum’s pipeline, its clinical development strategy in sickle cell disease, and its broader efforts in gene-expression modulation for rare diseases.
Fulcrum Therapeutics (Nasdaq: FULC) announced a positive business update and 2022 Q1 financial results. The company will present initial data from the Phase 1b trial of FTX-6058 for sickle cell disease at EHA Congress in June 2022. Additionally, the Phase 3 REACH trial of losmapimod for Facioscapulohumeral Muscular Dystrophy (FSHD) is set to begin in 2Q 2022. Financially, Fulcrum reported a net loss of $25.9 million, worsening from $17.0 million in Q1 2021, while collaboration revenue decreased to $2.6 million from $4.8 million. Cash reserves stood at $195.1 million, sufficient to fund operations into 2024.
Fulcrum Therapeutics (NASDAQ: FULC) announced the grant of nonstatutory stock options to four new employees, totaling 76,000 shares under its 2022 Inducement Stock Incentive Plan. The options, issued as of May 2, 2022, have an exercise price of $9.80 per share, aligning with the closing share price on that date. Each option has a ten-year term with vesting over four years. This initiative aims to motivate new hires and align their interests with the company's goals in treating genetically defined rare diseases, including facioscapulohumeral muscular dystrophy and sickle cell disease.
Fulcrum Therapeutics (Nasdaq: FULC) announced its participation in a fireside chat at the BofA Securities 2022 Healthcare Conference on May 12, 2022, at 11:20 a.m. PT (2:20 p.m. ET). A live audio webcast will be available on Fulcrum’s Investor Relations page, with an archived replay for 30 days. Fulcrum specializes in developing treatments for genetically defined rare diseases, with lead programs including losmapimod for facioscapulohumeral muscular dystrophy and FTX-6058 for sickle cell disease and beta-thalassemia, leveraging their proprietary FulcrumSeek™ product engine.
Fulcrum Therapeutics (Nasdaq: FULC) announced it will release its first quarter 2022 financial results on May 9, 2022, prior to market opening. A conference call will follow at 8:00 a.m. ET to discuss these results and recent corporate developments. The company focuses on rare genetic diseases, with lead programs targeting facioscapulohumeral muscular dystrophy and sickle cell disease. Their proprietary FulcrumSeek™ technology identifies drug targets to treat gene mis-expression.
Fulcrum Therapeutics (Nasdaq: FULC) announced the granting of stock options to six new employees as part of its 2022 Inducement Stock Incentive Plan. A total of 148,320 stock options, exercisable at $24.00 per share, have been awarded. The options vest over four years, with 25% vesting on the first anniversary of employment and the remainder vesting quarterly thereafter. Fulcrum, focused on genetically defined rare diseases, is developing therapies such as losmapimod for facioscapulohumeral muscular dystrophy and FTX-6058 for sickle cell disease.
Fulcrum Therapeutics (Nasdaq: FULC) recently presented promising data on losmapimod, a treatment for facioscapulohumeral muscular dystrophy (FSHD), at the American Academy of Neurology Annual Meeting. The presentations outlined clinical data supporting losmapimod's potential to slow disease progression. The company plans to initiate the Phase 3 REACH trial in Q2 2022, aiming to enroll approximately 230 adults. Losmapimod has received FDA Fast Track and Orphan Drug Designation, highlighting its significance as a potential therapeutic option for FSHD.
Fulcrum Therapeutics (Nasdaq: FULC) will host a Key Opinion Leader meeting on March 24, 2022, to discuss the unmet need in facioscapulohumeral muscular dystrophy (FSHD) and their Phase 3 REACH trial for losmapimod, an investigational treatment. Esteemed experts Dr. Nicholas Johnson and Dr. Jay Han will join company executives for insights on disease progression and treatment landscape. FSHD affects 16,000 to 38,000 in the U.S., causing debilitating symptoms with no approved treatments available. Registration for the webcast is available on their website.
Fulcrum Therapeutics (NASDAQ: FULC) announced significant findings demonstrating that Reachable Workspace (RWS) effectively measures functionality in patients with facioscapulohumeral muscular dystrophy (FSHD). Data from two Phase 2 studies indicated that losmapimod, an investigational treatment, preserved or improved function as measured by RWS. The company is set to begin the Phase 3 REACH trial in Q2 2022, enrolling approximately 230 adults. RWS will serve as the primary endpoint, emphasizing the need for objective measures of disease progression.
Fulcrum Therapeutics (Nasdaq: FULC) announced the granting of nonstatutory stock options to four new employees as part of its 2022 Inducement Stock Incentive Plan. A total of 31,520 stock options were awarded on March 7, 2022, each with an exercise price of $14.90, equal to the closing price of FULC's common stock on that date. The options will vest over a four-year period, starting with 25% vesting on the first anniversary of the employees’ start dates. The company focuses on treating genetically defined rare diseases.
Fulcrum Therapeutics (FULC) announced significant progress in its clinical trials during a business update on March 3, 2022. The company is set to initiate the Phase 3 REACH trial for losmapimod in the treatment of facioscapulohumeral muscular dystrophy (FSHD) by 2Q 2022, aiming to demonstrate efficacy and safety. Additionally, initial data from a Phase 1b trial for FTX-6058 in sickle cell disease is expected in 2Q 2022. Fulcrum reported a loss of $80.8 million for 2021 but ended the year with $218.2 million in cash, expected to sustain operations through 2024.
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