Welcome to our dedicated page for Hcw Biologics news (Ticker: HCWB), a resource for investors and traders seeking the latest updates and insights on Hcw Biologics stock.
HCW Biologics Inc. (NASDAQ: HCWB) is a clinical-stage biopharmaceutical company developing proprietary immunotherapies to treat diseases driven by chronic inflammation, particularly age-related and senescence-associated conditions. News about HCW Biologics often centers on its fusion protein platforms, clinical trial milestones, licensing deals, and capital markets activity.
A key focus of recent announcements is the company’s lead product candidate, HCW9302, an IL-2-based fusion molecule developed using its TOBI platform. HCW Biologics has reported dosing the first patient in a company-sponsored, multi-center Phase 1, first-in-human clinical trial in patients with alopecia areata, an autoimmune disease with no curative FDA-approved treatments. Updates on this trial include site openings, patient screening, and the study’s design to evaluate safety, determine a recommended dose, and assess effects on regulatory T cells and disease responses.
Investors following HCWB news also see regular coverage of the company’s TRBC-based programs, including preclinical and IND-enabling data for HCW11-040, a second-generation pembrolizumab-based immune checkpoint inhibitor, and HCW11-018b, a tetra-valent T-cell engager targeting tissue factor in solid tumors. Presentations at scientific meetings such as the Society for Immunotherapy of Cancer (SITC) and Virtual Investor segments highlight mechanistic data, safety findings in non-human primates, and potential advantages over first-generation therapies.
On the corporate side, HCW Biologics issues news about licensing and co-development agreements, such as its amended and restated license with Beijing Trimmune Biotech Co., Ltd., as well as its minority equity interest and licensing relationship with Wugen, Inc. Financing updates, including warrant inducement transactions, equity issuances under a Standby Equity Purchase Agreement, and Nasdaq listing compliance developments, are also frequent topics. For investors and observers, the HCWB news stream provides insight into scientific progress, partnership activity, and the company’s efforts to fund and advance its pipeline.
HCW Biologics (NASDAQ: HCWB) and WY Biotech formed joint venture Trimmune to develop HCW11-006 under an exclusive worldwide license, with Trimmune backed by CITIC and TigerMed.
Trimmune paid half of a $3.5M upfront fee ($1,750,000) today; HCW also received co-founder equity valued at approximately $3.5M (combined value ~$7.0M). Phase 1 in China is expected in H1 2027. HCW retains a royalty-free option to recapture Americas rights after Phase 1.
HCW Biologics (NASDAQ: HCWB) announced a warrant inducement agreement dated Nov 19, 2025 that amends exercise prices and triggers immediate exercises of prior warrants.
The investor agreed to a reduced exercise price of $2.66 for November 2024 and May 2025 warrants, resulting in exercises to purchase 167,925 and 1,342,280 shares respectively, with gross proceeds of approximately $4.0 million before fees. In return, HCW will issue 3,020,410 unregistered new warrants exercisable at $2.41, expiring 5.5 years after original issuance.
The closing is expected on or about Nov 20, 2025, Maxim Group LLC is financial advisor, and the company has agreed to file a registration statement covering resale of shares underlying the new warrants.
HCW Biologics (NASDAQ: HCWB) announced the first patient was dosed on Nov 18, 2025 at The Ohio State University Wexner Medical Center in a Company‑sponsored, multi‑center, first‑in‑human Phase 1 trial of HCW9302 for alopecia areata (NCT07049328).
HCW9302 is a subcutaneous interleukin‑2 fusion molecule designed to activate and expand regulatory T cells (Treg) to reduce autoimmune inflammation. The dose‑escalation study plans to treat up to 30 patients; primary goals are safety and determining a recommended Phase 2 dose. Secondary endpoints include disease response and effects on Treg proliferation and function.
HCW Biologics (NASDAQ: HCWB) reported Q3 2025 results and business highlights on Nov 14, 2025. The company expects to dose the first patient in a Phase 1 study of HCW9302 in Q4 2025 and opened two clinical sites for an alopecia areata trial. During Q3 the company issued 475,000 shares for $2.2M under its standby equity purchase agreement.
Q3 revenue was $15,606 (Q3 2024: $426,423); nine-month revenue was $27,222 (9M 2024: $2.2M). Q3 net loss was $4.6M; nine-month net loss was $8.7M. Management stated substantial doubt about going concern without additional funding and faces a Nasdaq equity-rule cure deadline of Dec 31, 2025.
HCW Biologics (NASDAQ: HCWB) presented updated preclinical data for its tetra-valent, pembrolizumab-based immune checkpoint inhibitor HCW11-040 at SITC2025 (Nov 5–9, 2025).
HCW11-040 is a multi-functional fusion protein combining pembrolizumab with IL-15, IL-7 domains and a TGF-β trap. Preclinical results reported: PD-1/PD-L1 blockade equivalent to pembrolizumab, superior expansion/activation of TPEX and memory T cells, enhanced human PBMC anti-tumor activity in organoid models, no evidence of excessive inflammatory responses after subcutaneous dosing, and a streamlined GMP-like manufacturing process.
HCW Biologics (NASDAQ: HCWB) presented preclinical data for its tetra-valent, TRBC-based T‑Cell Engager (TCE) program at the SITC 40th Annual Meeting (Nov 5–9, 2025) in National Harbor, MD.
Key points: the lead candidate HCW11-018b showed tumor shrinkage in xenograft and PDX models, 100% survival in treated tumor-bearing mice versus 0% in untreated controls, activation of exhausted tumor‑infiltrating T cells, favorable tolerability and long serum half-life in non‑human primates, subcutaneous dosing, and a streamlined GMP manufacturing process without Fc fusion.
HCW Biologics (NASDAQ: HCWB) announced its Chief Scientific Officer, Peter Rhode, PhD, participated in a Virtual Investor “What This Means” segment highlighting the company’s lead candidate HCW11-040, a pembrolizumab-based, tetra-specific fusion protein built on the TRBC platform.
HCW11-040 combines pembrolizumab with interleukin-7, interleukin-15, and TGF-β receptor components (TGF-β traps). Preclinical testing reportedly shows expansion of exhausted T cells (TPEX) without causing side effects. Detailed preclinical data will be presented in a poster at SITC on November 8, 2025.
HCW Biologics (NASDAQ: HCWB) announced it will participate in the 2025 Maxim Growth Summit held October 22–23 at The Hard Rock Hotel NYC.
Founder and CEO Dr. Hing C. Wong will meet one-on-one with institutional investors and senior Maxim analysts; the program includes CEO roundtables and keynote speakers. The company described the event as an opportunity to discuss its clinical-stage immunotherapy programs linking chronic inflammation and disease.
HCW Biologics (NASDAQ: HCWB) will present three posters at the 40th Annual Meeting of the Society for Immunotherapy of Cancer in National Harbor, MD (November 5–9, 2025).
Presentations on November 7–8 highlight IND‑enabling results for three lead drug candidates built on HCW’s proprietary TRBC platform: a Class III multi-specific T‑cell engager (Abstract 915), a Class II tetra‑specific pembrolizumab‑based immunotherapeutic (Abstract 1014), and a Class I cytokine fusion molecule HCW11‑006 (Abstract 276). Posters are scheduled in the Prince George ABC Exhibit Halls at Gaylord National Resort and Convention Center on November 7 and 8, 2025.
HCW Biologics (NASDAQ: HCWB), a clinical-stage biopharmaceutical company, presented its second-generation T-Cell Engager (TCE) program in a Virtual Investor segment. Chief Scientific Officer Dr. Peter Rhode discussed the company's recent advancements in their TCE technology.
The company's improved TCE program demonstrates enhanced manufacturability, safety profile, and effectiveness against solid tumors. These second-generation TCEs aim to address key limitations of first-generation treatments, including complex manufacturing, tolerability issues, and limited efficacy for solid tumors. HCW Biologics has positioned itself among select biotech companies developing innovative TCEs that can overcome resistance mechanisms.