Hemogenyx Awarded Grant

Rhea-AI Summary

Hemogenyx Pharmaceuticals (LSE:HEMO, OTC:HOPHF) has secured a $120,000 G-Rex® grant from ScaleReady, in partnership with Wilson Wolf Manufacturing and Cell Ready. The grant will support the optimization and scale-up of manufacturing for HG-CT-1, the company's lead CAR-T product candidate currently in Phase I trials for relapsed/refractory acute myeloid leukemia.

The funding will enable development of a closed-system, G-Rex®-based manufacturing platform, aimed at reducing production complexity, enhancing regulatory compliance, and lowering per-patient manufacturing costs. The grant includes technical consulting support in lean bioprocessing, regulatory strategy, and process engineering to support future clinical and commercial-scale manufacturing.

Positive

• Secured $120,000 grant to optimize CAR-T manufacturing process
• Access to technical consulting support for regulatory and process optimization
• Potential reduction in per-patient manufacturing costs through G-Rex platform
• Validation from industry leaders ScaleReady, Wilson Wolf, and Cell Ready

Negative

• Current manufacturing process requires optimization for commercial viability
• Complex regulatory compliance requirements for CAR-T production

Hemogenyx Pharmaceuticals Awarded G-Rex® Grant to Support Scalable, Cost-Optimized CAR-T Manufacturing

LONDON, UK / ACCESS Newswire / July 16, 2025 / Hemogenyx Pharmaceuticals plc (LSE:HEMO) is pleased to announce that it has been awarded a $120,000 G-Rex® grant from ScaleReady, in collaboration with Wilson Wolf Manufacturing and Cell Ready (the "Grant"), to support the optimization and scale-up of the manufacturing process for its lead CAR-T product candidate, HG-CT-1, currently in a Phase I clinical trial for relapsed/refractory acute myeloid leukemia (R/R AML) in adults.

The Grant will enable the Company to further develop a closed-system, G-Rex®-based, manufacturing platform, which is expected to reduce production complexity, streamline regulatory compliance, and significantly lower per-patient manufacturing costs. These advances are critical to the long-term commercial viability of autologous CAR-T therapies such as HG-CT-1.

The Grant also includes Company access to technical consulting in lean bioprocessing, regulatory and CMC strategy, and process engineering, strengthening Hemogenyx's capacity to support future clinical and commercial-scale manufacturing.

Dr. Vladislav Sandler, CEO & Co-Founder of Hemogenyx Pharmaceuticals, commented:

"This Grant provides targeted support for one of the most important aspects of CAR-T development: cost-effective, scalable manufacturing. As we continue to advance HG-CT-1 through clinical trials, optimizing our cGMP production process will be essential to maximizing both patient access and shareholder value. We are pleased to be working with industry leaders ScaleReady, Wilson Wolf, and Cell Ready, and we view this collaboration as a strong validation of the promise of our platform."

The Company anticipates that the G-Rex optimization will also generate a robust data package supporting the adoption of next-generation G-Rex® "M" series bioreactor systems, which reduce operator intervention and enable greater automation.

Hemogenyx remains focused on executing its clinical and operational milestones and will continue to update the market on its progress.

Market Abuse Regulation (MAR) Disclosure

Certain information contained in this announcement would have been inside information for the purposes of Article 7 of Regulation No 596/2014 (as it forms part of UK domestic law by virtue of the European Union (Withdrawal) Act 2018) until the release of this announcement.

Enquiries:

Hemogenyx Pharmaceuticals plc	https://hemogenyx.com
Dr Vladislav Sandler, Chief Executive Officer & Co-Founder	headquarters@hemogenyx.com
Peter Redmond, Director	peter.redmond@hemogenyx.com
SP Angel Corporate Finance LLP	Tel: +44 (0)20 3470 0470
Matthew Johnson, Vadim Alexandre, Adam Cowl
Peterhouse Capital Limited	Tel: +44 (0)20 7469 0930
Lucy Williams, Duncan Vasey, Charles Goodfellow

About Hemogenyx Pharmaceuticals plc

Hemogenyx Pharmaceuticals is a publicly traded company (LSE: HEMO) headquartered in London, with its US operating subsidiaries, Hemogenyx Pharmaceuticals LLC and Immugenyx LLC, located in New York City at its state-of-the-art research facility.

The Company is a clinical-stage biopharmaceutical group developing new medicines and treatments to treat blood and autoimmune disease and to bring the curative power of bone marrow transplantation to a greater number of patients suffering from otherwise incurable life-threatening diseases. Hemogenyx Pharmaceuticals is developing several distinct and complementary product candidates, as well as a platform technology that it uses as an engine for novel product development.

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

SOURCE: Hemogenyx Pharmaceuticals PLC

View the original press release on ACCESS Newswire

FAQ

What is the value of the G-Rex grant awarded to Hemogenyx (HOPHF)?

Hemogenyx received a $120,000 G-Rex® grant from ScaleReady, in collaboration with Wilson Wolf Manufacturing and Cell Ready.

What is the purpose of Hemogenyx's HG-CT-1 CAR-T therapy?

HG-CT-1 is being developed to treat relapsed/refractory acute myeloid leukemia (R/R AML) in adults and is currently in Phase I clinical trials.

How will the G-Rex grant benefit Hemogenyx's manufacturing process?

The grant will help develop a closed-system, G-Rex®-based manufacturing platform that reduces production complexity, streamlines regulatory compliance, and lowers per-patient manufacturing costs.

What stage of development is Hemogenyx's HG-CT-1 therapy in?

HG-CT-1 is currently in Phase I clinical trials for treating relapsed/refractory acute myeloid leukemia in adults.

What technical support does the G-Rex grant include for Hemogenyx?

The grant includes technical consulting in lean bioprocessing, regulatory and CMC strategy, and process engineering to support future clinical and commercial-scale manufacturing.