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IceCure Granted Notice of Allowance for U.S. Patent for its Next-Generation XSense™ Cryoprobes

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IceCure Medical (NASDAQ: ICCM) has received a Notice of Allowance from the U.S. Patent and Trademark Office for its next-generation XSense™ cryoprobe technology. The innovation enhances the company's liquid-nitrogen-based cryoablation platform, which is used for tumor destruction through freezing as an alternative to surgical removal.

The patented technology features a novel extraction method incorporating a heater, temperature sensor, and controlled gas pulses in the cryoprobe's tip. This advancement enables precise temperature management during probe extraction, reducing tissue trauma risk. The XSense™ System with Cryoprobes has already secured regulatory approval in both the U.S. and Israel.

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News Market Reaction

+1.96%
1 alert
+1.96% News Effect
+$1M Valuation Impact
$70M Market Cap
0.1x Rel. Volume

On the day this news was published, ICCM gained 1.96%, reflecting a mild positive market reaction. This price movement added approximately $1M to the company's valuation, bringing the market cap to $70M at that time.

Data tracked by StockTitan Argus on the day of publication.

The invention is designed to improve cryoprobe extraction, further reducing risk of tissue trauma, leading to lower costs and improved patient experience

XSense™ System with Cryoprobes recently received regulatory approval in the U.S. and Israel

CAESAREA, Israel, Sept. 18, 2025 /PRNewswire/ -- IceCure Medical Ltd. (NASDAQ: ICCM) ("IceCure", "IceCure Medical" or the "Company"), developer of minimally-invasive cryoablation technology that destroys tumors by freezing as an option to surgical tumor removal, today announced it has received a Notice of Allowance from the U.S. Patent and Trademark Office for its patent titled "Cryoprobe".

IceCure Medical Logo

"Our industry-leading liquid-nitrogen-based cryoablation platform has been further advanced with this latest invention, a cryoprobe technology," stated IceCure's Chief Executive Officer, Eyal Shamir. "There is an abundance of data, much of it from independent studies, showing that minimally invasive cryoablation procedures with our flagship ProSense® system have resulted in an improved patient experience with excellent medical outcomes. This new cryoprobe technology, which is integrated in our next-generation XSense™ system, further reduces any potential risk of tissue trauma as the cryoprobe is extracted from the patient at the end of the short, minimally invasive outpatient procedure."

This invention introduces a novel method for safely and efficiently extracting the cryoprobe after tissue freezing during cryoablation procedures. The cryoprobe's tip is integrated with a heater, temperature sensor, and controlled gas pulses, enabling precise estimation and management of the cryoprobe's external surface temperature—even while embedded in frozen tissue. Designed to be compatible with a wide range of XSense™ system cryoprobe types, the new cryoprobe technology is a versatile solution for multiple clinical scenarios.

About IceCure's Cryoablation Systems

IceCure's platform technology, including the ProSense® Cryoablation System and XSense™ Cryoablation System and CryoProbes, provides a minimally invasive treatment option to destroy tumors by freezing them. The systems uniquely harness the power of liquid nitrogen to create large lethal zones for maximum efficacy in tumor destruction in benign and cancerous lesions, including breast, kidney, lung, and liver.

IceCure's cryoablation systems enhance patient and provider value by accelerating recovery, reducing pain, surgical risks and complications. With easy, transportable design and liquid nitrogen utilization, ProSense® and XSense™ open the door to fast and convenient office-based procedure for breast tumors.

About IceCure Medical

IceCure Medical (Nasdaq: ICCM) develops and markets advanced liquid-nitrogen-based cryoablation therapy systems for the destruction of tumors (benign and cancerous) by freezing, with the primary focus areas being breast, kidney, bone and lung cancer. Its minimally invasive technology is a safe and effective alternative to hospital surgical tumor removal that is easily performed in a relatively short procedure. The Company's flagship ProSense® system is marketed and sold worldwide for the indications cleared and approved to date including in the U.S., Europe and Asia.

Forward Looking Statements
This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. Words such as "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates" and similar expressions or variations of such words are intended to identify forward-looking statements. For example, IceCure is using forward looking statements in this press release when it discusses: that data show that minimally invasive cryoablation procedures with the ProSense® system have resulted in an improved patient experience with excellent medical outcomes and that the ProSense® system reduces any potential risk of tissue trauma and the versatile prospective design compatibility with a wide range of XSense™ system cryoprobe types. Historical results of scientific research and clinical and preclinical trials do not guarantee that the conclusions of future research or trials will suggest identical or even similar conclusions. Important factors that could cause actual results, developments and business decisions to differ materially from those anticipated in these forward-looking statements include, among others: the Company's planned level of revenues and capital expenditures; the Company's available cash and its ability to obtain additional funding; the Company's ability to market and sell its products; legal and regulatory developments in the United States and other countries; the Company's ability to maintain its relationships with suppliers, distributors and other partners; the Company's ability to maintain or protect the validity of its patents and other intellectual property; the Company's ability to expose and educate medical professionals about its products; political, economic and military instability in the Middle East, specifically in Israel; as well as those factors set forth in the Risk Factors section of the Company's Annual Report on Form 20-F for the year ended December 31, 2024 filed with the SEC on March 27, 2025, and other documents filed with or furnished to the SEC which are available on the SEC's website, www.sec.gov. The Company undertakes no obligation to update these statements for revisions or changes after the date of this release, except as required by law.

IR Contact:

Email: investors@icecure-medical.com
Michael Polyviou
Phone: 732-232-6914

Logo: https://mma.prnewswire.com/media/2319310/IceCure_Medical_Logo.jpg

Cision View original content:https://www.prnewswire.com/news-releases/icecure-granted-notice-of-allowance-for-us-patent-for-its-next-generation-xsense-cryoprobes-302560245.html

SOURCE IceCure Medical

FAQ

What is the new patent granted to IceCure Medical (NASDAQ: ICCM)?

IceCure received a Notice of Allowance for a patent titled 'Cryoprobe' for its next-generation XSense™ technology, featuring improved extraction methods with integrated heater, temperature sensor, and controlled gas pulses.

What are the key benefits of IceCure's new XSense™ cryoprobe technology?

The technology reduces tissue trauma risk during probe extraction, enables precise temperature management, and improves patient experience during minimally invasive outpatient procedures.

Where has IceCure's XSense™ System received regulatory approval?

The XSense™ System with Cryoprobes has received regulatory approval in both the United States and Israel.

How does IceCure's cryoablation technology work?

IceCure's technology uses liquid-nitrogen-based cryoablation to destroy tumors by freezing them, offering a minimally-invasive alternative to surgical tumor removal.

What makes IceCure's new cryoprobe technology versatile?

The technology is designed to be compatible with various XSense™ system cryoprobe types, making it suitable for multiple clinical scenarios.
Icecure Medical Ltd.

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