Top U.S. Honor Roll Hospital Expands Use of INSPIRA™ ART100 System to Lung Transplant Procedures

Rhea-AI Summary

Inspira Technologies (NASDAQ: IINN) announced that a top U.S. Honor Roll hospital has expanded the use of its INSPIRA™ ART100 system to include lung transplantation procedures. The hospital, ranked among the nation's top 20 by U.S. News & World Report 2025-2026, made this decision following positive experience with the system in previous clinical applications.

This expansion into lung transplantation, one of the most demanding respiratory care applications, represents significant validation of the ART100 system's performance and clinical value. The development follows Inspira's recent securing of multi-million dollar binding government orders for ART100 systems, highlighting the company's growing commercial presence.

Positive

• Expansion into critical lung transplantation procedures by a top-ranked U.S. hospital
• Recent multi-million dollar government orders secured for ART100 systems
• Growing adoption by leading medical institutions validates technology effectiveness
• Potential to become standard of care in complex surgical settings

Negative

• None.

Insights

Medical Technology Analyst

Prestigious hospital adoption of ART100 for lung transplants validates technology and expands Inspira's market potential in complex procedures.

The expansion of the INSPIRA™ ART100 system into lung transplantation at a top-ranked U.S. hospital represents a significant clinical validation milestone for Inspira Technologies. Lung transplantation is among the most complex and demanding respiratory procedures, requiring exceptional reliability and performance from life-support systems.

This adoption pattern follows the classic technology implementation curve in specialized medical settings - initial limited use followed by expansion to more critical applications once safety and efficacy are established. The fact that a U.S. News & World Report Honor Roll hospital with specialties ranked in the top five nationally has chosen to expand the system's use speaks volumes about its clinical performance.

The respiratory support market has historically been dominated by conventional ECMO systems and ventilators with limited innovation. Inspira's ART100 appears to be gaining traction as a differentiated platform technology that can address multiple clinical scenarios. This versatility significantly expands the potential market opportunities beyond the initial use cases.

This expansion comes alongside recently secured government contracts, suggesting growing commercial momentum across both institutional and governmental sectors. For medical technology companies, establishing beachhead reference customers at prestigious institutions often accelerates broader market adoption as other hospitals look to these centers of excellence for guidance.

The respiratory support device market is projected to grow substantially, and gaining early footholds in specialized procedures like transplantation positions Inspira to capture market share as the technology becomes more widely adopted. The ability to demonstrate efficacy in such demanding clinical applications will likely facilitate expansion into additional use cases and markets.

RA'ANANA, Israel, Sept. 02, 2025 (GLOBE NEWSWIRE) -- Inspira™ Technologies OXY B.H.N. Ltd. (NASDAQ: IINN) ("Inspira," “Inspira Technologies,” or the "Company"), a pioneer in innovative life-support and diagnostic technologies, today announced that a top U.S. hospital, has expanded its clinical use of the INSPIRA™ ART100 system to lung transplantation procedures, one of the most demanding applications in advanced respiratory care. The hospital was included in the U.S. News & World Report 2025-2026 Best Hospitals Honor Roll of the nation’s top 20 hospitals, and has multiple specialties consistently ranked among the top five nationwide.

This clinical expansion follows the hospital’s positive experience with the ART100 system in prior clinical use. The decision by one of the nation’s most highly ranked hospitals to extend the use of Inspira’s technology into such a critical and complex surgical procedure provides strong external validation of the system’s performance and clinical value. Expanding the application of the ART100 into lung transplantation highlights its potential as a reliable platform for advanced respiratory support across multiple indications.

Dagi Ben-Noon, Chief Executive Officer of Inspira Technologies, stated: “The decision by one of the most decorated and respected medical institutions in the United States to broaden the use of our ART100 system into lung transplantation is a highly meaningful step for Inspira. It reflects the growing confidence leading hospitals are placing in our technology and underscores its potential to become an essential platform in advanced respiratory care. This expansion marks an important step toward establishing the ART100 as part of the standard of care in the most complex surgical settings.”

This U.S. clinical expansion follows Inspira’s recently announced multi-million dollar binding government orders for ART100 systems, underscoring the Company’s growing global footprint and commercial momentum.

About Inspira Technologies

Inspira Technologies is a commercial-stage medical device company specializing in advanced respiratory support and real-time blood monitoring solutions. The Company’s U.S. Food and Drug Administration -cleared INSPIRA™ ART100 system is approved for cardiopulmonary bypass in the U.S. and ECMO (Extracorporeal Membrane Oxygenation) procedures outside the U.S and serves as a foundation for the development of the INSPIRA ART500, a next-generation system designed to deliver oxygenation while patients remain awake and spontaneously breathing. Inspira Technologies is also advancing HYLA™, a proprietary blood sensor platform offering continuous, non-invasive monitoring. With multiple cleared products, a growing IP portfolio, and strategic streamlining of its operations, Inspira Technologies is increasingly positioned as an attractive platform within the life-support and MedTech landscape. The Company’s recent internal shifts may reflect broader alignment with long-term industry trends, including consolidation, cross-sector collaboration, and potential strategic partnerships. For more information, visit: https://inspira-technologies.com

Forward-Looking Statement Disclaimer

This press release contains express or implied forward-looking statements pursuant to U.S. Federal securities laws. These forward-looking statements are based on the current expectations of the management of the Company only and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. For example, the Company is using forward-looking statements when it discusses the expanded use of the ART100 by a leading U.S. hospital, particularly during lung transplant procedures, that the decision to expand the use of the ART100 during such a complex surgical procedure provides strong external validation of the system’s performance and an indication of its clinical value, that expanding the application of the ART100 into lung transplantation highlights the ART100’s potential as a reliable platform for advanced respiratory support across multiple indications, that the expanded use of the ART100 reflects the growing confidence leading hospitals are placing in its technology and underscores the ART100’s potential to become an essential platform in advanced respiratory care and that the expansion marks an important step toward establishing the ART100 as part of the standard of care in the most complex surgical settings. These forward-looking statements and their implications are based solely on the current expectations of the Company's management and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. Except as otherwise required by law, the Company undertakes no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. More detailed information about the risks and uncertainties affecting the Company is contained under the heading "Risk Factors" in the Company's annual report on Form 20-F for the fiscal year ended December 31, 2024, filed with the U.S. Securities and Exchange Commission (the "SEC"), which is available on the SEC's website at www.sec.gov.

Company Contact
Inspira Technologies – Media Relations
Email: info@inspirao2.com
Phone: +972-9-9664485

FAQ

What is the significance of the INSPIRA ART100 system's expansion into lung transplant procedures?

The expansion validates the system's clinical value and performance, as it's now being used in one of the most demanding respiratory care applications by a top U.S. Honor Roll hospital.

Which hospital is using Inspira Technologies' (IINN) ART100 system?

While not named specifically, the hospital is among the top 20 hospitals in the U.S. News & World Report 2025-2026 Best Hospitals Honor Roll, with multiple specialties ranked in the top five nationwide.

What recent commercial developments has Inspira Technologies (IINN) achieved?

The company has secured multi-million dollar binding government orders for ART100 systems, demonstrating growing commercial momentum and global expansion.

How is the INSPIRA ART100 system being implemented in clinical settings?

The system is being implemented in both previous clinical applications and now expanded to include complex lung transplantation procedures, showcasing its versatility as a platform for advanced respiratory support.