Immunocore Holdings plc reports commercial and clinical developments for a biotechnology issuer whose Nasdaq-listed ADSs represent ordinary shares. The company uses its ImmTAX TCR bispecific immunotherapy platform across oncology, infectious disease and autoimmune programs, with KIMMTRAK (tebentafusp-tebn) approved for HLA-A*02:01-positive adults with unresectable or metastatic uveal melanoma in the United States, European Union, Canada, Australia and the United Kingdom.
Recurring updates cover KIMMTRAK sales and long-term survival data, lifecycle-management studies in uveal and cutaneous melanoma, the PRAME-A02 candidate brenetafusp, earlier ImmTAX candidates, HIV functional-cure research, autoimmune disease pipeline activity, financial results, investor presentations and R&D governance changes.
Immunocore Holdings plc (Nasdaq: IMCR) has announced its upcoming participation in the 43rd Annual J.P. Morgan Healthcare Conference in San Francisco, California. The company, which specializes in developing transformative immunomodulating medicines for cancer, infectious diseases, and autoimmune diseases, will deliver a presentation on Wednesday, January 15, 2025, at 8:15 a.m. PST.
The presentation will be accessible through a live webcast on the 'Events & Presentations' section of Immunocore's website under the 'Investors' tab. A replay of the presentation will be available for a time after the event.
Immunocore Holdings plc (Nasdaq: IMCR) has appointed Travis Coy as Executive Vice President (EVP), Chief Financial Officer and Head of Corporate Development, effective January 1, 2025. Coy transitions from his role as Non-Executive Director, which he held since September 2019, to become an Executive Officer.
Coy brings over 20 years of experience from Eli Lilly and Company, where he most recently served as Vice President, Head of Transactions and M&A, Corporate Business Development. His previous roles at Eli Lilly included leading business development for oncology and cardiometabolic diseases, financial leadership of the oncology business unit, Director of Investor Relations, and Director of Corporate Finance and Investment Banking.
The appointment leverages Coy's deep knowledge of Immunocore's operations and science, gained during his five-year tenure as a Non-Executive Director, to support the company's mission in delivering transformative immunomodulating medicines for cancer, infectious diseases, and autoimmune diseases.
Immunocore (IMCR) has initiated the Phase 1 trial of IMC-P115C, its first half-life extended ImmTAC candidate, with the first patient now dosed. IMC-P115C targets PRAME (PReferentially expressed Antigen in MElanoma) and shares the same CD3 effector and TCR specificity as brenetafusp, but is designed with an extended half-life to improve patient convenience through reduced treatment frequency.
The Phase 1 dose escalation trial will evaluate safety, pharmacokinetics, and clinical activity in HLA-A*02:01-positive patients with advanced cancers expressing PRAME. This marks Immunocore's sixth ImmTAC candidate to enter clinical trials, building upon their existing PRAME dataset from brenetafusp's Phase 1/2 trials.
Immunocore (IMCR) has initiated patient treatment in a Phase 1/2 trial for IMC-R117C, their fifth ImmTAC candidate, targeting PIWIL1 in colorectal and other gastrointestinal cancers. The trial will evaluate both monotherapy and combination treatments with standard care in HLA-A*02:01-positive patients with advanced solid tumors.
IMC-R117C represents the first immunotherapy program targeting PIWIL1, a cancer-testis antigen overexpressed in multiple malignancies, including colorectal cancer (CRC). The company estimates up to 20,000 colorectal cancer patients globally are positive for both PIWIL1 and HLA-A*02:01. This development addresses a significant unmet medical need, particularly in advanced colorectal cancer cases resistant to standard treatments.
Immunocore (NASDAQ: IMCR) and EORTC have initiated the first Phase 3 Adjuvant Trial in Ocular Melanoma (ATOM), enrolling their first patient. The trial aims to evaluate if tebentafusp can prevent or delay relapse in high-risk uveal melanoma patients after primary treatment, compared to observation.
The open-label, international, multicenter trial will enroll 290 HLA-A*02:01-positive patients who have undergone surgery or radiotherapy. Participants will be randomized 1:1 to receive either tebentafusp for six months or observation. The study will assess overall survival, safety, tolerability, and explore ctDNA as a marker of residual disease.
Tebentafusp (KIMMTRAK®) is currently approved in 38 countries for treating HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma.
Immunocore (IMCR) announced that KIMMTRAK (tebentafusp) has been recommended for funding through England's National Health Service (NHS) by NICE. This recommendation overturns their initial negative decision from May 2023. KIMMTRAK is approved for HLA-A*02:01-positive adults with unresectable or metastatic uveal melanoma, marking the first treatment to improve survival for this rare form of melanoma. The therapy will be funded on the NHS in England starting December 2, 2024, representing Immunocore's 13th launch this year.
Immunocore Holdings (Nasdaq: IMCR), a commercial-stage biotechnology company focused on developing immunomodulating medicines, has announced its participation in two upcoming investor conferences. The company will present at the Guggenheim Securities Healthcare Innovation Conference on Tuesday, November 12, 2024, at 1:00 p.m. EST, and the Jefferies London Healthcare Conference on Wednesday, November 21, 2024, at 9:00 a.m. GMT.
Both presentations will be available via webcast on Immunocore's website in the 'Events & Presentations' section, with replays available for a time after the events.
Immunocore (IMCR) reported strong Q3 2024 financial results with KIMMTRAK net revenues of $80.2 million, representing 28% growth over Q3 2023. The company achieved earnings per share of $0.17, compared to $0.02 in Q3 2023. KIMMTRAK is now approved in 38 countries and launched in 21 countries globally. The company continues to advance its pipeline with ongoing Phase 3 trials in cutaneous melanoma and plans to start randomization for the Phase 3 ATOM trial in adjuvant uveal melanoma in Q4 2024. Cash position remains strong at $901.3 million as of September 30, 2024.
Immunocore Holdings plc (Nasdaq: IMCR) presented Phase 1 data for brenetafusp, an ImmTAC bispecific targeting PRAME, in platinum-resistant ovarian cancer patients at the 2024 ESMO Congress. Key findings include:
1. Monotherapy: 58% disease control rate, 6.5% RECIST response rate, and 3.3 months median PFS in heavily pre-treated patients.
2. Chemotherapy combination: 69% disease control rate and 23% RECIST response rate.
3. T cell fitness (TCF) gene expression signature in blood associated with improved clinical outcomes across different tumor types.
The data suggests potential for brenetafusp in ovarian cancer, particularly in earlier-line treatment where TCF is expected to be higher.
Immunocore Holdings plc (Nasdaq: IMCR), a commercial-stage biotechnology company, has announced its participation in the 2024 Cantor Global Healthcare Conference. The company, which focuses on developing immunomodulating medicines for cancer, infectious diseases, and autoimmune diseases, will be part of a fireside chat on Thursday, September 19, 2024, at 12:45 p.m. EDT.
The presentation will be webcast live and can be accessed through the 'Events & Presentations' section under 'Events' on the 'Investors' page of Immunocore's website. A replay of the presentation will be available for a time after the event.