Welcome to our dedicated page for Immutep news (Ticker: IMMP), a resource for investors and traders seeking the latest updates and insights on Immutep stock.
Immutep Limited (IMMP) news covers a late-stage biotechnology company focused on Lymphocyte Activation Gene-3 (LAG-3)–related immunotherapies for cancer and autoimmune disease. The company regularly reports clinical, regulatory and corporate developments across its diversified LAG-3 portfolio, led by the MHC Class II agonist eftilagimod alfa (efti) and the LAG-3 agonist antibody IMP761.
On this page, readers can follow updates on Immutep’s major oncology programs, including the global TACTI-004 (KEYNOTE-F91) Phase III trial in first-line non-small cell lung cancer, as well as Phase II and investigator-initiated studies in head and neck squamous cell carcinoma, soft tissue sarcoma and metastatic breast cancer. News items highlight trial milestones such as patient enrolment progress, primary endpoint readouts, translational biomarker data and presentations at international conferences like the European Society for Medical Oncology (ESMO), the World Conference on Lung Cancer and the San Antonio Breast Cancer Symposium.
For autoimmune disease, Immutep publishes updates on the Phase I program for IMP761, a first-in-class LAG-3 agonist antibody designed to silence dysregulated self-antigen-specific memory T cells. News coverage includes safety, pharmacodynamic findings and proof-of-concept data from the ongoing first-in-human study.
Investors can also track regulatory interactions, such as Fast Track designations, FDA feedback on late-stage development strategies and completion of Project Optimus requirements, alongside business developments like the strategic collaboration and exclusive licensing agreement with Dr. Reddy’s Laboratories for efti in selected global markets. Corporate news, including R&D tax incentives from French and Australian government programs and quarterly activity reports, provides additional context on funding and operational progress.
Bookmark this page to monitor Immutep’s latest announcements, clinical data disclosures and SEC Form 6-K filings that shape the outlook for IMMP and its LAG-3–focused pipeline.
Immutep Limited (ASX: IMM; NASDAQ: IMMP) has announced the grant of patent no. ZL201580013695.X by the Chinese Patent Office for LAG525, an antibody molecule aimed at treating cancer and infectious diseases. This patent follows prior grants in Australia, the U.S., Europe, and Japan. LAG525, a humanized form of IMP701, is currently being evaluated in clinical trials in collaboration with Novartis AG. The patent, set to expire on March 13, 2035, is co-owned by Novartis and Immutep S.A.S.
Immutep has announced that the first patient has been enrolled and dosed in the INSIGHT-003 trial, evaluating a triple combination therapy for metastatic non-small cell lung carcinoma. This innovative approach combines Immutep’s lead product candidate, eftilagimod alpha (efti), with standard chemotherapy and anti-PD-1 therapy. The trial aims to recruit up to 20 patients, with initial results expected in 2022, marking a significant milestone in cancer treatment research.
Immutep Limited has entered late-stage development in the LAG-3 immunotherapy space, focusing on its lead product, eftilagimod alpha (efti). Recent data presented at ASCO highlights its efficacy in treating non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC). Immutep is collaborating with Merck KGaA for a new trial evaluating efti with bintrafusp alpha. The company plans to initiate a Phase III study in metastatic breast cancer, while cash reserves have increased to $60.59 million as of June 30, 2021.
Immutep Limited (ASX: IMM; NASDAQ: IMMP) has received FDA and IRB approval to launch the TACTI-003 trial, assessing the efficacy of its lead product candidate, eftilagimod alpha, in combination with KEYTRUDA in first-line treatment for Head and Neck Squamous Cell Carcinoma (HNSCC). Recruitment for the trial, which will include around 154 patients, is set to begin this quarter, with locations across Australia, Europe, and the U.S. Immutep aims to evaluate overall response rates and other efficacy metrics in this pivotal study.
Immutep Limited has announced the initiation of a new Phase I clinical trial, INSIGHT-003, aimed at evaluating the combination of its lead product candidate, eftilagimod alpha (efti), with chemotherapy and anti-PD-1 therapy in patients with various solid tumors. The trial will recruit up to 20 patients, with the expected first patient enrollment in Q3 2021 and interim results anticipated in 2022. All regulatory approvals are in place for the trial, marking a significant step in enhancing treatment options for cancer patients.
Immutep announced a successful A$60 million private placement of new ordinary shares to professional and institutional investors. The first tranche will be completed without shareholder approval, while the second tranche awaits approval. Funds will support the expansion of clinical programs and manufacturing processes for eftilagimod alpha. New Shares will be issued at A$0.52 each, reflecting a 12.9% discount. Settlement dates are set for late June and July 2021. Additionally, a share purchase plan targeting A$5 million will be offered to eligible shareholders.
Immutep Limited (NASDAQ: IMMP) announced a significant update on its collaboration with Cardiff University to develop a new generation of small molecule anti-LAG-3 therapies aimed at providing affordable oral treatments for cancer patients. This project, leveraging Immutep's expertise in LAG-3 biology and Cardiff's medicinal chemistry skills, aims to produce compounds with lower costs compared to existing antibodies. The joint venture will result in shared intellectual property, enabling Immutep exclusive rights to develop these novel therapeutic molecules commercially.
Immutep Limited announced positive final data from its Phase I INSIGHT-004 study, revealing a 41.7% objective response rate and 50% disease control rate among 12 patients with various solid tumors. Notably, 75% of patients remain alive. The study evaluated the combination of eftilagimod alpha and avelumab, demonstrating encouraging activity even in patients with low PD-L1 expression. The treatment maintained a good safety profile with no dose-limiting toxicities, supporting further clinical evaluation of this novel therapy.
Immutep Limited (ASX: IMM; NASDAQ: IMMP) announced positive interim data from the Phase II TACTI-002 study, demonstrating a 41.7% overall response rate (ORR) for first-line non-small cell lung cancer (NSCLC) and 29.7% ORR for second-line head and neck squamous cell carcinoma (HNSCC). The study showed significant tumor responses across PD-L1 subgroups, with safe and well-tolerated results. The median progression-free survival (PFS) was 8.2 months for NSCLC and 12.6 months for HNSCC. Further recruitment into the trial is ongoing, promising advancements in treatment.
Immutep Limited (ASX: IMM; NASDAQ: IMMP) announced the grant of a new European patent (EP3473263) for combined preparations in cancer treatment. This patent follows previous grants in November 2018 and early 2021, enhancing the protection of their lead candidate eftilagimod alpha (IMP321) alongside PD-1/PD-L1 inhibitors. Valid until January 8, 2036, this patent reinforces Immutep's commitment to clinical development and commercialization of innovative therapies. CEO Marc Voigt highlighted the patent's importance for ongoing trials, especially those presented at the upcoming ASCO 2021 Annual Meeting.