In8Bio (INAB) Stock News

IN8bio (Nasdaq: INAB) announced CEO and co-founder William Ho will present at two February investor and scientific conferences: Noble Emerging Growth Virtual Equity Conference on Feb 5, 2026 (3:00 p.m. ET, virtual) and IO360° Conference on Feb 12, 2026 (1:20–1:40 p.m. ET) with a plenary on DeltEx DRI and Phase 1/2 GBM results.

Webcast and registration details will be posted in the company’s Events & Presentations section at the corporate website.

IN8bio (NASDAQ: INAB) reported updated Phase 1/2 data for repeat-dose DeltEx™ Drug-Resistant Immunotherapy γδ T cells (DeltEx DRI) in newly diagnosed glioblastoma presented Jan 12, 2026. Across multiple centers (DeltEx DRI N=14; contemporaneous SOC N=10) median progression-free survival mPFS was 13.0 months vs 6.6 months for SOC (+97%). Median overall survival mOS is currently 17.2+ months for DeltEx DRI versus 13.2 months for SOC (+30.3%), with several patients progression-free 1.4–4.6 years. Treatment was well tolerated: no DLTs, no treatment-related SAEs, no CRS, and no ICANS. Company will use late‑2025 financing to support FDA discussions on potential clinical pathways.

IN8bio (Nasdaq: INAB) announced a private placement priced at-the-market to raise up to $40.2 million, with an initial closing of approximately $20.1 million expected around Dec 22, 2025. The initial tranche sells 5,127,029 shares at $1.38 and pre-funded warrants for up to 9,452,677 shares (exercise price $0.0001). The company may receive an additional $20.1 million subject to preclinical milestones and share-price conditions. Net proceeds are intended to fund IND-enabling studies for INB-619, generate early animal data in 2026, support potential IND submission in 2027, submit INB-200/INB-400 glioblastoma data to the FDA, and provide working capital into the first half of 2027.

IN8bio (Nasdaq: INAB) reported Q3 2025 results and program updates on Nov 6, 2025. The company presented new preclinical data on INB-619 showing CD19-targeted γδ T cell engager potency comparable to FDA-approved CD19/CD20 engagers with minimal cytokine release, and advanced its γδ T cell platform.

IN8bio expanded the Phase 1 INB-100 trial to The Ohio State University to accelerate enrollment and plans updated INB-200/400 GBM data at SNO (Nov 19-23, 2025) and additional INB-619 preclinical data at ASH (Dec 6-9, 2025).

Q3 financials: R&D $2.1M, G&A $1.9M, net loss $3.9M (‑$0.85/share), and cash $10.7M as of Sep 30, 2025.

IN8bio (Nasdaq: INAB) announced that The Ohio State University has been added as a new clinical site in the ongoing Phase 1 trial of INB-100, a donor-derived allogeneic gamma-delta T cell therapy for patients receiving haploidentical stem cell transplants for leukemia.

The company said the addition aims to accelerate enrollment of the expansion cohort and deliver follow-up data next year. IN8bio noted clinical observations including long-term leukemic remissions beyond four and five years in earliest-treated patients, persistence and expansion of INB-100 up to 1 year, and an absence of severe graft-versus-host disease in presented data. Trial identifier: NCT03533816.

IN8bio (Nasdaq: INAB) on Oct. 27, 2025 presented preclinical data for INB-619, a pan-γδ T cell engager targeting CD19 for autoimmune disease. In SLE donor models INB-619 achieved complete B cell elimination with efficacy described as equivalent to approved engagers blinatumomab and mosunetuzumab, while producing markedly lower IL-6 and other cytokines. INB-619 expanded both Vδ1+ and Vδ2+ γδ T cell subsets and did not activate CD4+ or CD8+ αβ T cells in these assays. Data were presented at the 2025 ACR Convergence Meeting and are preclinical, indicating potential for deeper B cell depletion with a cytokine-sparing profile.

IN8bio (Nasdaq: INAB) reported significant clinical progress and financial results for Q2 2025. The company achieved a remarkable milestone in its INB-200 glioblastoma trial, with one patient surpassing four years without progression. Clinical data presented at ASCO 2025 showed patients receiving multiple doses achieved median progression-free survival of 16.1 months, more than double the standard-of-care outcome.

The company received recognition for its DeltEx™ manufacturing platform and presented promising preclinical data for INB-619, a gamma-delta T cell engager showing potential in lupus treatment. Financial results showed R&D expenses of $2.5M and G&A expenses of $2.7M, with a cash position of $13.2M extending runway into June 2026.

IN8bio announced a significant milestone in their Phase 1 trial of INB-200 gamma-delta T cell therapy for glioblastoma (GBM). A patient with grade 4, IDH-mutant glioma has achieved 4 years of remission and survival, maintaining good quality of life and returning to work. The Phase 1 trial data presented at ASCO 2025 showed INB-200's median progression-free survival (mPFS) of 16.1 months, more than double the 6.9 months typically seen with standard treatment. INB-200, the first genetically modified gamma-delta T cell therapy for GBM, has demonstrated a favorable safety profile and potential long-term benefits, marking a potential breakthrough in GBM treatment where standard care hasn't improved beyond 14-16 months overall survival in over 20 years.

IN8bio (NASDAQ: INAB) announced positive Phase 1 trial results for INB-200, their gamma-delta T cell therapy for newly diagnosed glioblastoma multiforme (GBM). The therapy demonstrated a median progression-free survival of 16.1 months in patients receiving multiple doses, more than double the 6.9 months typically observed with standard-of-care Stupp protocol. Four patients (40%) receiving repeated doses remain alive and progression-free for over two years, with three returning to work. The treatment showed favorable safety profile with no serious toxicities, cytokine release syndrome, or immune effector cell-associated neurotoxicity syndrome. The company's Drug Resistant Immunotherapy (DRI) uses genetically modified gamma-delta T cells delivered directly into the brain in combination with standard maintenance chemotherapy. Preliminary Phase 2 trial data for INB-400 also shows promising results with mPFS at 10.8 months.