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Inhibrx Biosciences, Inc. reports clinical and corporate updates for a pipeline of biologic therapeutic candidates developed with protein engineering platforms. The company’s programs include ozekibart (INBRX-109), a tetravalent death receptor 5 agonist antibody studied in oncology indications including chondrosarcoma, colorectal cancer and Ewing sarcoma, and INBRX-106, a hexavalent OX40 agonist evaluated in immuno-oncology settings such as head and neck squamous cell carcinoma.
Company developments commonly cover clinical trial data, regulatory submissions and designations, scientific conference presentations, quarterly and annual financial results, and capital resources. Inhibrx Biosciences also carries a completed corporate history tied to its 2024 separation from Inhibrx, Inc. following the sale of the INBRX-101 program.
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Inhibrx, Inc. (Nasdaq: INBX) announced the initiation of a registration-enabling trial for INBRX-101, a recombinant human AAT-Fc fusion protein targeting emphysema due to alpha-1 antitrypsin deficiency. This trial, named ElevAATe, includes 36 patients receiving doses every three weeks and aims to measure functional AAT concentration over 32 weeks across 35 sites in the U.S., Australia, and New Zealand. Additionally, the FDA lifted the partial clinical hold on INBRX-109, a DR5 agonist. Patient enrollment for INBRX-109 will resume next month, with data anticipated by late 2023 for Phase 1 cohorts and late 2024 for the registration trial data. The company continues to advance its clinical pipeline in oncology and rare diseases.
Inhibrx, Inc. (NASDAQ: INBX) reported its financial results for Q4 and fiscal year 2022, showing significant increases in cash and cash equivalents, totaling $273.9 million, up from $131.3 million in 2021. R&D expenses rose to $30.5 million in Q4, compared to $18.6 million in the previous year, and net loss widened to $40.9 million or $0.95 per share. Key clinical updates include the initiation of INBRX-101's trial for Alpha-1 Antitrypsin Deficiency expected in April 2023 and promising results from INBRX-105. Despite increased operational costs, the company remains focused on advancing its clinical pipeline.