Incyte Corp Stock Price, News & Analysis

On November 2, 2020, Eli Lilly and Incyte announced positive long-term data for Olumiant (baricitinib) to be presented at ACR Convergence 2020. Key findings show that 27.5% of csDMARD-IR and 18.4% of bDMARD-IR patients achieved Low Disease Activity after 2.3 years. In a 5-year study, low rates of radiographic progression were maintained across various RA patient populations. No new safety concerns were identified, reinforcing Olumiant's long-term efficacy and safety for moderate to severe rheumatoid arthritis treatments.

Eli Lilly and Incyte announced new data for baricitinib presented at the 29th annual EADV Congress, showcasing its long-term efficacy in treating moderate to severe atopic dermatitis. In the BREEZE-AD3 Phase 3 study, over 40% of patients maintained clear skin after 68 weeks of treatment. Baricitinib received EU approval for adult patients who qualify for systemic therapy. The safety profile aligns with previous studies, reinforcing its potential role in managing this chronic condition ultimately impacting approximately 1-3% of adults worldwide.

Eli Lilly and Incyte presented data for baricitinib at the virtual Fall Clinical Dermatology meeting from Oct 29 to Nov 1, 2020. The Phase 2 study (BRAVE-AA1) evaluated its efficacy in adult patients with alopecia areata (AA). Results showed significant improvement in patients achieving a SALT score ≤20 at 36 weeks, with the 4-mg dose showing 51.9% improvement versus 3.6% for placebo (p=0.001). Following positive Phase 2 results, Phase 3 trials (BRAVE-AA1 and BRAVE-AA2) have been initiated. The FDA has granted Breakthrough Therapy designation for baricitinib for AA due to unmet medical needs.

Incyte announced positive results from a pooled analysis of two Phase 3 studies, TRuE-AD1 and TRuE-AD2, evaluating ruxolitinib cream for treating mild-to-moderate atopic dermatitis. The studies showed significant efficacy in reducing itch and improving skin severity, as measured by EASI and SCORAD tools. Key findings included 52.6% and 62.0% responder rates for ruxolitinib cream at different concentrations. The safety profile was consistent with previous findings, and an NDA submission to the FDA is anticipated by the end of the year.

Incyte has scheduled its Q3 2020 financial results conference call for November 5, 2020, at 8:00 a.m. ET. The press release will precede the call, available at 7:00 a.m. ET. Investors can access the live webcast and slides through Incyte's investor relations website. Replay options are also provided for both domestic and international calls. The conference ID for the call is 13711777.

Incyte is dedicated to addressing serious medical needs through innovative therapeutics.

Eli Lilly and Incyte announced new data demonstrating that baricitinib, in combination with remdesivir, significantly reduces recovery time for hospitalized COVID-19 patients. The Adaptive COVID-19 Treatment Trial (ACTT-2) revealed a median recovery time improvement from 8 to 7 days, with a 12.5% relative reduction. Notably, mortality rates dropped 35% through Day 29 among patients receiving the combination therapy, particularly benefiting those requiring supplemental oxygen. Lilly is pursuing Emergency Use Authorization from the FDA for baricitinib's COVID-19 treatment.

Nimble Therapeutics has formed a strategic collaboration with Incyte (NASDAQ: INCY) to develop innovative peptide therapies across various disease areas. This collaboration aims to leverage Nimble's advanced peptide synthesis and screening platform to enhance drug discovery. Under the agreement, Nimble will receive an undisclosed upfront payment, research program reimbursements, and potential milestone payments and royalties. Incyte retains exclusive rights to develop and commercialize any resulting peptides, with possibilities for further collaboration on additional targets.

Eli Lilly and Incyte announced that the European Medicines Agency's CHMP has issued a positive opinion for baricitinib (OLUMIANT®) to treat moderate to severe atopic dermatitis (AD) in adults. This marks a significant step towards regulatory approval in Europe, potentially making it the first JAK inhibitor approved for AD. The opinion is based on the Phase 3 BREEZE-AD clinical trials which demonstrated efficacy and safety. A final decision from the European Commission is expected within two months, highlighting the urgency for more treatment options for patients suffering from AD.