MiNK Therapeutics Announces New Data Showing MiNK-215 Drives Potent Anti-Tumor Activity in Treatment-resistant Solid Tumors

Rhea-AI Summary

MiNK Therapeutics (NASDAQ: INKT) on November 20, 2025 published preclinical data for MiNK-215, an allogeneic, IL-15–enhanced FAP-targeting CAR-iNKT designed to remove FAP+ cancer-associated fibroblasts and boost immune infiltration in solid tumors.

Key preclinical findings show MiNK-215: dismantles stromal barriers, selectively eliminates FAP+ fibroblasts, remodels the tumor microenvironment, activates dendritic cell and antigen-presentation pathways, repolarizes macrophages to a pro-inflammatory state, and enables deep tumor-specific T cell infiltration in refractory lung and MSS colorectal cancer models.

MiNK-215 is described as an off-the-shelf therapy manufacturable at scale to address solid tumors resistant to checkpoint inhibitors.

• MiNK-215, an IL-15 armoured FAP-targeting CAR-iNKT, targets and clears tumor-protective FAP+ fibroblasts to allow immune cells to infiltrate and kills cancer cells
  
• Activates multiple immune pathways to generate potent, lasting anti-tumor activity in lung and MSS colorectal cancer models
  

NEW YORK, Nov. 20, 2025 (GLOBE NEWSWIRE) -- MiNK Therapeutics, Inc. (NASDAQ: INKT), a clinical-stage biopharmaceutical company pioneering allogeneic invariant natural killer T (iNKT) cell therapies to treat cancer and immune disorders, today announced the publication of new preclinical data for MiNK-215, a novel, next-generation FAP-targeting, IL-15–enhanced CAR-iNKT therapy. The manuscript, titled The allogeneic FAP-CAR-IL15 iNKT therapy MiNK-215 remodels the tumor stroma to enhance antitumor immunity”, is now available on Cancer Immunology Research website here.

MiNK-215 is engineered to eliminate FAP-positive cancer-associated fibroblasts (CAFs)—the cells that build the dense, immunosuppressive stroma blocking immune infiltration in solid tumors and contributing heavily to immunotherapy failure. Using MiNK’s proprietary allogeneic platform, MiNK-215 also secretes IL-15 to enhance persistence, immune activation, and durability.

Key Findings: MiNK-215 tackles the two fundamental barriers: the physical stroma that blocks immune entry and the dysfunctional immune circuitry inside the tumor. Specifically,

• Dismantles the protective stromal barrier and selectively eliminates FAP+ cancer-associated fibroblasts, clearing the path for robust immune infiltration.
• Reprograms the immune landscape in preclinical models of refractory lung and MSS colon cancer liver metastases, MiNK-215:
  • Remodeled the tumor microenvironment
  • Activated dendritic cells and antigen-presentation pathways
  • Re-polarized macrophages to pro-inflammatory, cancer killing state
  • Enabled deep infiltration of tumor-specific T cells

As an “off-the-shelf” therapy, MiNK-215 can be manufactured at scale and delivered on demand—offering a new therapeutic strategy for patients with solid tumors that have long been unresponsive to checkpoint inhibitors and other immune-based treatments.

“The findings published today underscore the real potential of MiNK-215 to reshape how we treat solid tumors that have resisted immunotherapy for decades. By dismantling the fibroblast barriers that shield these cancers and activating multiple arms of the immune system, MiNK-215 goes beyond traditional checkpoint approaches. As an allogeneic, off-the-shelf therapy, it represents a meaningful step toward delivering scalable, immediate immune engagement for patients who currently have few effective options,” said Jennifer Buell, PhD, President and CEO of MiNK Therapeutics.

About MiNK Therapeutics

MiNK Therapeutics is a clinical-stage biopharmaceutical company pioneering the development of allogeneic invariant natural killer T (iNKT) cell therapies and precision immune modulators designed to restore immune balance and drive durable cytotoxic responses. MiNK’s proprietary iNKT platform bridges innate and adaptive immunity to address cancer, autoimmune disease, and immune collapse.

Its lead candidate, AgenT-797, is an off-the-shelf, cryopreserved iNKT cell therapy currently in clinical trials for solid tumors, graft-versus-host disease (GvHD), and critical pulmonary immune failure. MiNK’s pipeline also includes TCR-based and neoantigen-targeted iNKT programs that enable tissue-specific immune activation. With a scalable manufacturing process and broad therapeutic potential, MiNK is advancing a new class of immune reconstitution therapies designed to deliver durable, accessible, and globally deployable treatments.

About MiNK-215
MiNK-215 is engineered to eliminate FAP-positive cancer-associated fibroblasts (CAFs)—the cells that build the dense, immunosuppressive stroma blocking immune infiltration in solid tumors and contributing heavily to immunotherapy failure. Using MiNK’s proprietary allogeneic platform, MiNK-215 also secretes IL-15 to enhance persistence, immune activation, and durability.

Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the federal securities laws, including statements regarding the potential, safety, clinical benefit, and development plans for AgenT-797 and other iNKT-based therapies. These statements involve risks and uncertainties, including those described under “Risk Factors” in MiNK’s most recent SEC filings. MiNK undertakes no obligation to update these statements except as required by law.

Contacts

Investor Contact: 917-362-1370 | investor@minktherapeutics.com
Media Contact: 781-674-4428 | communications@minktherapeutics.com
Source: MiNK Therapeutics

FAQ

What did MiNK Therapeutics announce on November 20, 2025 about MiNK-215 (INKT)?

MiNK published preclinical data showing MiNK-215 remodels tumor stroma, removes FAP+ fibroblasts, and enhances immune infiltration in lung and MSS colorectal cancer models.

How does MiNK-215 (INKT) work to improve immune response in solid tumors?

MiNK-215 targets and clears FAP-positive cancer-associated fibroblasts and secretes IL-15 to boost persistence and immune activation.

Which tumor models showed activity with MiNK-215 in the November 20, 2025 data release?

Preclinical activity was reported in refractory lung cancer models and MSS colorectal cancer liver metastasis models.

Is MiNK-215 an autologous or off-the-shelf therapy for INKT investors?

MiNK-215 is described as an allogeneic, off-the-shelf CAR-iNKT therapy that can be manufactured at scale and delivered on demand.

What immune changes did MiNK-215 induce in preclinical studies according to the announcement?

The therapy activated dendritic cells and antigen-presentation pathways, repolarized macrophages to a pro-inflammatory state, and enabled deep tumor-specific T cell infiltration.

Does the November 20, 2025 announcement provide clinical trial results or regulatory approvals for INKT's MiNK-215?

No; the announcement reports preclinical data and does not report clinical trial readouts or regulatory approvals.