Welcome to our dedicated page for Inovio Pharmaceu news (Ticker: INO), a resource for investors and traders seeking the latest updates and insights on Inovio Pharmaceu stock.
Inovio Pharmaceuticals, Inc. (NASDAQ: INO) is a biotechnology company developing DNA medicines for HPV-related diseases, cancer, and infectious diseases. The INO news feed on Stock Titan aggregates company-issued press releases, regulatory updates, and other market-moving disclosures so readers can follow how INOVIO’s DNA medicine programs progress over time.
A major focus of recent INOVIO news is INO-3107, an investigational DNA medicine for adults with recurrent respiratory papillomatosis (RRP), a rare HPV-related disease of the respiratory tract. Updates include completion of a rolling Biologics License Application (BLA), FDA acceptance of the BLA for review under a Standard classification, and discussion of the accelerated approval pathway. News items also highlight clinical data showing reductions in the number of surgeries required by trial participants and long-term durability results from retrospective analyses.
Investors can also find announcements on capital-raising transactions, such as underwritten public offerings of common stock and warrants disclosed in Form 8-K filings and related press releases. INOVIO frequently reports on financial results, including quarterly earnings releases, as well as corporate governance and compensation matters like inducement stock option grants under its Inducement Plan.
Additional coverage includes scientific and clinical milestones, such as publication of Phase 1 proof-of-concept data for DNA-Encoded Monoclonal Antibody (DMAb) technology in Nature Medicine and preclinical progress in DNA-encoded protein (DPROT) programs. Conference participation and investor events are also regular topics. For followers of INO stock, this news page offers a centralized view of the company’s clinical, regulatory, financial, and strategic communications.
INOVIO Pharmaceuticals (Nasdaq: INO) has successfully closed its underwritten public offering of 20,355,000 shares at $8.50 each, generating approximately $173 million in gross proceeds. This includes an additional 2,655,000 shares purchased due to the underwriters' full exercise of their option. The offering was executed under an automatically effective shelf registration statement filed with the SEC on January 20, 2021. Funds from this offering are expected to enhance INOVIO's capabilities in developing DNA medicines for infectious diseases and cancer.
INOVIO Pharmaceuticals (Nasdaq: INO) announced the pricing of an underwritten public offering of 17.7 million shares of common stock at $8.50 per share, expected to yield approximately $150.5 million in gross proceeds. The offering includes an option for underwriters to purchase an additional 2.655 million shares. Proceeds will support clinical development, including INO-4800, and general corporate purposes. The offering is anticipated to close on January 25, 2021, following customary conditions. This offering was registered with the SEC and aims to advance INOVIO's DNA medicine pipeline.
INOVIO Pharmaceuticals announced a public offering of $150 million in common stock, with plans to grant underwriters a 30-day option for an additional 15%. Proceeds will fund clinical development, specifically for INO-4800, and cover general corporate expenses. BofA Securities, Jefferies, and Cantor are managing the offering. This follows their shelf registration statement filed with the SEC, effective January 20, 2021. The offering is subject to market conditions, and there are no guarantees regarding its completion.
INOVIO (NASDAQ: INO) announced promising results from a Phase 2 trial of VGX-3100 for HPV-16/18-associated vulvar dysplasia. At six months post-treatment, 63% of participants showed a clinically significant reduction in lesions, a stark contrast to the typical 2% spontaneous resolution rate. Notably, 15% of participants had resolved lesions with no detectable virus. The trial confirmed VGX-3100's safety, with no severe adverse events reported. INOVIO plans to advance to Phase 3 development based on these results, representing a potential breakthrough in non-surgical treatment options.
INOVIO (NASDAQ: INO) announces a collaboration with Advaccine Biopharmaceuticals to commercialize its COVID-19 DNA vaccine candidate INO-4800 in Greater China, including Mainland China, Hong Kong, Macao, and Taiwan. Advaccine will exclusively develop, manufacture, and market INO-4800 for an upfront payment of $3 million and potential milestone payments totalling $108 million. INOVIO will receive royalties on annual net sales. The collaboration leverages Advaccine’s manufacturing capabilities and clinical data to support INOVIO’s global regulatory filings while advancing the Phase 2 clinical trial of INO-4800 in China, involving 640 subjects.
INOVIO (NASDAQ: INO) has published peer-reviewed Phase 1 clinical data for its COVID-19 DNA vaccine candidate, INO-4800, in EClinicalMedicine. The study involved 40 healthy adults and demonstrated that INO-4800 generated an immune response in all participants with favorable safety, showing only six minor adverse events. The vaccine maintains stability at room temperature over a year, aiding global distribution. INOVIO is advancing to Phase 2 trials, funded by the U.S. Department of Defense, further validating the vaccine's safety and efficacy in upcoming segments.
INOVIO (NASDAQ: INO) announced a $37.6 million grant from DARPA to develop DNA-encoded monoclonal antibodies (dMAbs) targeting SARS-CoV-2. This funding will complement INOVIO's ongoing INO-4800 vaccine trial, enhancing treatment options for COVID-19. The dMAb technology offers rapid, cost-effective production of antibodies, overcoming limitations of traditional methods. The collaboration includes The Wistar Institute and AstraZeneca, aiming to advance dMAb candidates into preclinical studies and human trials within a year.
INOVIO (NASDAQ: INO) and Advaccine Biopharmaceuticals have initiated the Phase 2 clinical trial for INO-4800, a DNA vaccine candidate against COVID-19, in China. The trial, which is independent of the ongoing U.S. trial, aims to enroll 640 participants aged 18 and older, focusing on safety and immunogenicity. Dr. Joseph Kim, INOVIO's CEO, emphasized the collaboration's significance in accelerating vaccine development. The trial will consist of two doses at varying levels, providing critical data to support further evaluations of INO-4800.
INOVIO (NASDAQ:INO) announced positive Phase 2 results for its DNA medicine VGX-3100, which treats HPV-16/18-associated anal dysplasia. The trial showed a 50% resolution of precancerous anal lesions in subjects six months post-treatment, indicating VGX-3100 is safe and well-tolerated. The study involved 23 participants, with the primary endpoint being the absence of dysplasia and HPV-16/18 detected in tissue samples. INOVIO plans to initiate a Phase 3 trial and seek rare disease designation for this treatment in 2021, amidst rising anal cancer incidences attributed to HPV.
INOVIO (NASDAQ: INO) announced the initiation of the Phase 2 segment of its INNOVATE clinical trial for its COVID-19 vaccine candidate, INO-4800, with the first subject dosed. The trial aims to enroll around 400 participants at 17 U.S. sites, focusing on safety, tolerability, and immunogenicity to confirm dosing levels for subsequent Phase 3 evaluation. Funded by the U.S. Department of Defense, the trial signifies an important step in INOVIO's response to the pandemic, leveraging its DNA technology known for its safety profile and thermostability.