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Opus Genetics Added to the Russell 3000®, Russell 2000® and Russell Microcap® Indexes

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Opus Genetics (Nasdaq: IRD), a clinical-stage gene therapy company for inherited retinal diseases, will join the Russell 3000®, Russell 2000® and Russell Microcap® Indexes when the U.S. market opens on June 29, 2026, following the June 2026 Russell indexes reconstitution.

Membership is based on market-capitalization rankings determined by FTSE Russell and lasts until the next semi-annual reconstitution. Russell US indexes are widely used as benchmarks, with about $12.2 trillion in assets benchmarked to them as of June 2025.

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Positive

  • Added to Russell 3000®, Russell 2000® and Russell Microcap® indexes effective June 29, 2026
  • Exposure to Russell US indexes that had about $12.2 billion benchmarked assets as of June 2025

Negative

  • None.

News Market Reaction – IRD

+7.53%
27 alerts
+7.53% Session close to close
+6.7% Peak in 2 hr 12 min
$341.00M Market Cap
0.5x Rel. Volume

In the Jun 26 session, IRD gained 7.53%, reflecting a notable positive market reaction. Argus tracked a peak move of +6.7% during that session. Our momentum scanner triggered 27 alerts that day, indicating elevated trading interest and price volatility.

Data tracked by StockTitan Argus on the day of publication.

Market Context

The stock moved +7.5% in the session following this news. A strong positive reaction aligns with inc...
Analysis

The stock moved +7.5% in the session following this news. A strong positive reaction aligns with increased index inclusion visibility and potential passive fund demand tied to Russell additions. However, existing resale registration capacity and recent net insider selling could still weigh if enthusiasm fades.

Key Figures

Index coverage universe: 4,000 stocks Benchmarked assets: $12.2 trillion
2 metrics
Index coverage universe 4,000 stocks Maximum number of U.S. stocks captured in Russell US indexes at reconstitution
Benchmarked assets $12.2 trillion Assets benchmarked to Russell US indexes as of end of June 2025

Historical Context

5 past events · Latest: Jun 16 (Positive)
Pattern 5 events
Date Event Sentiment 24h Move Catalyst
Jun 16 Pipeline update Positive +4.1% Outlined progress and timelines across five IRD gene therapy programs and cash runway.
Jun 02 R&D event Neutral -3.2% Announced plans to host a virtual R&D Science Forum on IRD pipeline programs.
May 28 Equity inducements Neutral +3.8% Reported stock option inducement grants for new non-executive employees under 2021 plan.
May 27 Conference presentation Neutral +1.2% Scheduled presentation at the 2026 Jefferies Global Healthcare Conference with webcast access.
May 13 Conference presentation Neutral -2.9% Announced presentation at the RBC Capital Markets 2026 Global Healthcare Conference.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

Recent news has produced mixed, mostly moderate price reactions, with both aligned and divergent moves relative to event tone.

Key Terms

russell 3000, russell 2000, russell microcap, ftse russell
4 terms
russell 3000 financial
"added as a member of the broad-market Russell 3000®, the Russell 2000®"
A broad stock-market index made up of the roughly 3,000 largest publicly traded U.S. companies, ranked by their total market value. It serves as a wide “basket” of American stocks that reflects the overall performance of the U.S. equity market, so investors use it as a benchmark or to gain broad exposure through index funds and ETFs—similar to watching an economy-sized shopping cart to judge how an entire store is doing.
russell 2000 financial
"member of the broad-market Russell 3000®, the Russell 2000® and the Russell Microcap®"
An index that tracks the performance of roughly 2,000 smaller publicly traded U.S. companies, ranked by their size measured in market value. Investors use it like a thermometer for the small‑company segment of the stock market: it shows how that part of the market is doing, serves as a common benchmark for small‑cap funds, and helps gauge risk appetite and economic trends that often affect smaller businesses more than large ones.
russell microcap financial
"Russell 3000®, the Russell 2000® and the Russell Microcap® Indexes, effective when"
An index that tracks the smallest publicly traded U.S. companies, the Russell Microcap represents the microcap segment of the market and serves as a benchmark for funds and investors focused on very small stocks. It matters to investors because it shows how this high-risk, high-reward slice of the market is performing — like a thermometer for tiny businesses, useful for gauging potential growth, volatility and liquidity compared with larger firms.
ftse russell financial
"Russell US indexes, which belong to FTSE Russell, the global index provider."
FTSE Russell is a global index provider that creates and maintains lists (indexes) showing how groups of stocks perform, similar to a scoreboard that ranks companies by size, sector and trading activity. Investors use these indexes as benchmarks and as the basis for investment products like index funds and ETFs, so when a stock is added or removed it can trigger buying or selling that affects its price and liquidity.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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RESEARCH TRIANGLE PARK, N.C., June 26, 2026 (GLOBE NEWSWIRE) -- Opus Genetics, Inc. (Nasdaq: IRD) (the “Company” or “Opus Genetics”), a clinical-stage biopharmaceutical company developing gene therapies to restore vision and prevent blindness in patients with inherited retinal diseases (IRDs), today announced the Company will be added as a member of the broad-market Russell 3000®, the Russell 2000® and the Russell Microcap® Indexes, effective when the U.S. market opens on June 29, 2026, as part of the June 2026 Russell indexes reconstitution.

“We are pleased to be included in these Russell indexes, which provide validation of the progress we’re making in advancing our gene therapies for inherited retinal diseases,” said George Magrath, M.D., Chief Executive Officer of Opus Genetics. “We welcome the enhanced visibility within the investment community as we continue on our strategic path.”

The June reconstitution of the Russell US indexes captures up to the 4,000 largest US stocks as of April 30, ranking them by total market capitalization. Membership in the Russell 3000® Index, which remains in place until the next semi-annual reconstitution, means automatic inclusion in the large-cap Russell 1000® Index or small-cap Russell 2000® Index as well as the appropriate growth and value style indexes. FTSE Russell determines membership for its Russell indexes primarily by objective, market-capitalization rankings and style attributes.

Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for active investment strategies. According to data as of the end of June 2025, approximately $12.2 trillion in assets were benchmarked against the Russell US indexes, which belong to FTSE Russell, the global index provider.

About Opus Genetics

Opus Genetics is a clinical-stage biopharmaceutical company developing gene therapies to restore vision and prevent blindness in patients with inherited retinal diseases (IRDs). The Company is developing durable, one-time treatments designed to address the underlying genetic causes of severe retinal disorders. The Company’s pipeline includes seven AAV-based programs, led by OPGx-LCA5 for LCA5-related mutations and OPGx-BEST1 for BEST1-related retinal degeneration, with additional candidates targeting RDH12, MERTK, RHO, CNGB1 and NMNAT1. The Company is based in Research Triangle Park, NC. For more information, visit www.opusgtx.com.

Forward-Looking Statements

This press release contains certain statements that are not statements of historical fact and are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. Such statements include, but are not limited to, statements related to our inclusion in the Russell indexes and related benefits, the clinical development, clinical results, preclinical data and future plans for OPGx-LCA5, OPGx-BEST1, OPGx-MERTK, OPGx-RDH12, OPGx-RHO and earlier stage programs, and expectations regarding us, our business prospects and our results of operations, and are subject to certain risks and uncertainties posed by many factors and events that could cause our actual business, prospects and results of operations to differ materially from those anticipated by such forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those described under the heading “Risk Factors” included in our most recent Annual Report on Form 10-K for the year ended December 31, 2025, our Quarterly Report on Form 10-Q for the quarter ended March 31, 2026, and in our other filings with the U.S. Securities and Exchange Commission. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. These forward-looking statements are based upon our current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties. In some cases, you can identify forward-looking statements by the following words: “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “aim,” “may,” “ongoing,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. We undertake no obligation to publicly update any forward-looking statements in order to reflect events or circumstances that might subsequently arise.

Contacts:

Investors
Jenny Kobin
Remy Bernarda
IR Advisory Solutions
ir@opusgtx.com

Media

Kimberly Ha
KKH Advisors
917-291-5744
kimberly.ha@kkhadvisors.com


FAQ

What did Opus Genetics (Nasdaq: IRD) announce about the Russell indexes on June 26, 2026?

Opus Genetics announced it will be added to the Russell 3000®, Russell 2000® and Russell Microcap® Indexes. According to Opus Genetics, inclusion follows the June 2026 Russell US index reconstitution and takes effect when U.S. markets open on June 29, 2026.

When will Opus Genetics (IRD) be added to the Russell 3000, Russell 2000 and Russell Microcap indexes?

Opus Genetics will join the Russell 3000®, Russell 2000® and Russell Microcap® Indexes on June 29, 2026. According to Opus Genetics, the additions become effective at the U.S. market open, following the completion of the June 2026 Russell US indexes reconstitution process.

What does Russell 3000 index inclusion mean for Opus Genetics (IRD) shareholders?

Inclusion means Opus Genetics stock will be part of the broad-market Russell 3000® Index. According to Opus Genetics, this membership lasts until the next semi-annual reconstitution and also results in placement within the appropriate style indexes tracked by many institutional investors.

How are companies like Opus Genetics selected for the Russell 3000 and Russell 2000 indexes?

Companies are selected primarily using objective market-capitalization rankings and style attributes determined by FTSE Russell. According to FTSE Russell, the June reconstitution captures up to the 4,000 largest U.S. stocks as of April 30, assigning them to Russell 1000® or Russell 2000® and related style indexes.

How much investment is benchmarked to Russell US indexes, and why does it matter for IRD stock?

Approximately $12.2 trillion in assets were benchmarked to Russell US indexes as of June 2025. According to FTSE Russell, these indexes guide index funds and active strategies, so Opus Genetics’ inclusion may increase its visibility among institutional investors tracking these benchmarks.