Welcome to our dedicated page for Iteos Therapeutics news (Ticker: ITOS), a resource for investors and traders seeking the latest updates and insights on Iteos Therapeutics stock.
iTeos Therapeutics news covers the former clinical-stage biopharmaceutical company's immuno-oncology pipeline, including programs aimed at tumor immunology and immunosuppressive pathways such as the TIGIT/CD226 axis and the adenosine pathway. Recurring updates include clinical data for belrestotug combinations, EOS-984, EOS-215 and other preclinical programs, financial results, conference presentations and collaboration developments.
Recent company developments also include the termination of the belrestotug development program, a strategic review and wind-down of operations, and completed corporate-status changes tied to the acquisition of the company's common stock, Nasdaq delisting and Exchange Act deregistration.
iTeos Therapeutics (ITOS) reported Q3 2024 financial results and business updates. The company received EMA clearance for belrestotug 400mg + dostarlimab as Phase 3 dose for GALAXIES Lung-301 clinical sites in EU. Pro forma cash position stood at $683.9M as of September 30, 2024, expected to provide runway through 2027. Q3 R&D expenses increased to $36.7M from $30.6M year-over-year, while G&A expenses decreased to $12.1M from $12.6M. Net loss widened to $45.4M ($1.05 per share) compared to $32.2M ($0.90 per share) in Q3 2023.
iTeos Therapeutics (ITOS) announced upcoming presentations of preclinical, translational, and clinical data for inupadenant at the ESMO Immuno-Oncology Congress 2024 in Geneva. The presentations will include results from the Phase 2 A2A-005 trial studying inupadenant combined with platinum-doublet chemotherapy in post-immunotherapy metastatic non-small cell lung cancer (NSCLC) patients. The data will be presented through two mini oral presentations and one poster session on December 12, 2024, focusing on inupadenant's effects on humoral responses and its combination with chemotherapy in NSCLC patients.
iTeos Therapeutics announced promising interim data from the GALAXIES Lung-201 Phase 2 study, evaluating belrestotug + dostarlimab in first-line, PD-L1 high non-small cell lung cancer (NSCLC) patients. Key findings include:
1. Clinically meaningful objective response rate (ORR) of 63.3-76.7% observed across all doses
2. Confirmed ORR (cORR) of ~60% for every dose, showing a >30% difference compared to dostarlimab monotherapy
3. Safety profile consistent with known checkpoint inhibitor combinations
The company believes these results support the potential differentiation of their TIGIT:PD-1 doublet and the ongoing GALAXIES Lung-301 Phase 3 registration study.
iTeos Therapeutics (Nasdaq: ITOS), a clinical-stage biopharmaceutical company focused on immuno-oncology therapeutics, has announced its participation in two upcoming investor conferences in September 2024. The company will be present at the Wells Fargo Healthcare Conference on September 4 in Boston, and the Cantor Fitzgerald Global Healthcare Conference on September 18 in New York.
At both events, iTeos management will engage in fireside chats and one-on-one investor meetings. The Wells Fargo conference presentation is scheduled for 4:30 PM ET, while the Cantor Fitzgerald conference presentation will take place at 10:20 AM ET. Interested parties can access live webcasts of the presentations through the Investors section of iTeos' website, with archived replays available for approximately 30 days post-event.
iTeos Therapeutics (Nasdaq: ITOS) announced that interim data from the Phase 2 GALAXIES Lung-201 study will be presented at the European Society for Medical Oncology (ESMO) Congress 2024. The study, sponsored by iTeos' partner GSK, assesses the belrestotug + dostarlimab doublet in previously untreated, unresectable, locally advanced or metastatic PD-L1 high non-small cell lung cancer. The presentation, titled 'Interim Analysis of GALAXIES Lung-201,' is scheduled for September 14, 2024, at 8:30 am CEST as a late-breaking oral presentation. This Phase 2 randomized, open-label platform study focuses on patients with PD-L1 high (TPS ≥50%) NSCLC. The abstract will be published on the ESMO website at 00:05 am CEST on the day of the presentation.
iTeos Therapeutics (Nasdaq: ITOS) reported Q2 2024 financial results and provided business updates. Key highlights include:
- Multiple clinical milestones expected in H2 2024, including two Phase 2 trials of belrestotug + dostarlimab in 1L NSCLC and 1L HNSCC
- Pro forma cash and investments of $714.4 million as of June 30, 2024, expected to provide runway through 2027
- Q2 2024 R&D expenses increased to $36.7 million from $29.2 million in Q2 2023
- Q2 2024 net loss of $7.1 million ($0.18 per share) compared to $34.3 million ($0.96 per share) in Q2 2023
The company is advancing multiple clinical programs, including belrestotug for NSCLC and HNSCC, and adenosine pathway inhibitors inupadenant and EOS-984.
iTeos Therapeutics (Nasdaq: ITOS) has appointed David Feltquate, M.D., Ph.D., as Chief Medical Officer. Dr. Feltquate will oversee the company's clinical development and regulatory strategies. He brings nearly 20 years of experience in immuno-oncology clinical development, translational medicine, and diagnostic assay advancement.
Prior to joining iTeos, Dr. Feltquate served as Chief Medical Officer at Palleon Pharmaceuticals and held leadership positions at Novartis and Bristol Myers Squibb. Notably, he was responsible for the clinical development of the first PD-1 inhibitor at Bristol Myers Squibb. Dr. Feltquate's appointment comes at a pivotal moment for iTeos as it aims to become a leading oncology company and advance its pipeline, including its TIGIT franchise.
iTeos Therapeutics announced the dosing of the first patient in its GALAXIES Lung-301 Phase 3 trial, testing the combination of belrestotug and dostarlimab against placebo and pembrolizumab in patients with advanced PD-L1 high NSCLC. The milestone has triggered a $35 million payment from GSK, iTeos' partner. This trial is the first to evaluate the TIGIT:PD-1 doublet therapy, informed by promising interim Phase 2 results. iTeos and GSK's collaboration, established in June 2021, included a $625 million upfront payment with potential milestone payments up to $1.45 billion and a profit-sharing agreement in the US.
iTeos Therapeutics and GSK have commenced the Phase 3 GALAXIES Lung-301 study to evaluate the combination of belrestotug and dostarlimab in untreated, unresectable, locally advanced, or metastatic PD-L1 selected non-small cell lung cancer (NSCLC). This landmark study will enroll approximately 1,000 patients globally, comparing the doublet therapy to a placebo plus pembrolizumab. The study's primary endpoints include progression-free survival and overall survival. Encouraging interim results from the Phase 2 GALAXIES Lung-201 study showed significant tumor reduction and a favorable safety profile with belrestotug and dostarlimab, prompting the initiation of the Phase 3 trial.
iTeos Therapeutics, Inc. (Nasdaq: ITOS) reported positive results for the belrestotug + dostarlimab combination in lung cancer, completed successful enrollment in head and neck cancer trials, and raised $120 million in a direct offering. The company's cash balance of $715 million as of May 10, 2024, is expected to fund operations through 2027.