Invivyd Announces Continued Neutralizing Activity of PEMGARDA® (pemivibart) and VYD2311 Against Currently Dominant SARS-CoV-2 Variant XFG (“Stratus”)
Invivyd (NASDAQ:IVVD) has announced that its COVID-19 antibody PEMGARDA® (pemivibart) and its next-generation candidate VYD2311 maintain strong neutralizing activity against the dominant XFG ("Stratus") SARS-CoV-2 variant. The company reports that COVID-19 cases are rising, with high viral activity in 12 states and growing infections in 34 states according to CDC data.
PEMGARDA, which is FDA-authorized for pre-exposure prophylaxis in certain immunocompromised patients, has demonstrated consistent effectiveness against all clinical variants since the Omicron BA.2 lineage. The company will submit new in vitro neutralization data to the FDA for inclusion in PEMGARDA's Healthcare Provider Fact Sheet.
Invivyd (NASDAQ:IVVD) ha comunicato che il suo anticorpo contro il COVID-19 PEMGARDA® (pemivibart) e il candidato di nuova generazione VYD2311 mantengono una forte attività neutralizzante contro la variante predominante XFG ("Stratus") del SARS-CoV-2. L'azienda rileva un aumento dei casi di COVID-19, con elevata attività virale in 12 stati e crescita dei contagi in 34 stati, secondo i dati CDC.
PEMGARDA, autorizzato dalla FDA per la profilassi pre-esposizione in alcuni pazienti immunocompromessi, ha mostrato un'efficacia costante contro tutte le varianti cliniche a partire dalla linea Omicron BA.2. L'azienda invierà nuovi dati di neutralizzazione in vitro alla FDA per l'inserimento nella Healthcare Provider Fact Sheet di PEMGARDA.
Invivyd (NASDAQ:IVVD) ha anunciado que su anticuerpo contra la COVID-19 PEMGARDA® (pemivibart) y su candidato de próxima generación VYD2311 mantienen una fuerte actividad neutralizante frente a la variante dominante XFG ("Stratus") del SARS-CoV-2. La compañía informa que los casos de COVID-19 están en aumento, con alta actividad viral en 12 estados y creciente número de infecciones en 34 estados, según datos de los CDC.
PEMGARDA, autorizado por la FDA para profilaxis previa a la exposición en ciertos pacientes inmunocomprometidos, ha demostrado eficacia constante contra todas las variantes clínicas desde la línea Omicron BA.2. La compañía remitirá nuevos datos de neutralización in vitro a la FDA para su inclusión en la hoja informativa para proveedores de salud de PEMGARDA.
Invivyd (NASDAQ:IVVD)는 자사의 COVID-19 항체 PEMGARDA® (pemivibart)와 차세대 후보물질 VYD2311이 우세한 XFG("Stratus") SARS-CoV-2 변이에 대해 강한 중화 활성을 유지한다고 발표했습니다. 회사는 CDC 데이터에 따르면 12개 주에서 높은 바이러스 활동이 관찰되고 34개 주에서 감염이 증가하고 있다고 보고했습니다.
PEMGARDA는 특정 면역저하 환자에 대해 FDA의 노출 전 예방(프리익스포저) 승인을 받았으며, Omicron BA.2 계열 이후 모든 임상 변이에 대해 일관된 효능을 보였습니다. 회사는 PEMGARDA의 의료 제공자용 설명서에 포함하기 위해 새로운 시험관 내 중화 데이터(in vitro)를 FDA에 제출할 예정입니다.
Invivyd (NASDAQ:IVVD) a annoncé que son anticorps anti-COVID-19 PEMGARDA® (pemivibart) et son candidat de nouvelle génération VYD2311 conservent une forte activité neutralisante contre le variant dominant XFG (« Stratus ») du SARS-CoV-2. L'entreprise signale une hausse des cas de COVID-19, avec une activité virale élevée dans 12 États et une augmentation des infections dans 34 États, d'après les données du CDC.
PEMGARDA, autorisée par la FDA pour la prophylaxie pré-exposition chez certains patients immunodéprimés, a montré une efficacité constante contre toutes les variantes cliniques depuis la lignée Omicron BA.2. L'entreprise soumettra de nouvelles données de neutralisation in vitro à la FDA pour qu'elles soient intégrées à la fiche d'information destinée aux professionnels de santé de PEMGARDA.
Invivyd (NASDAQ:IVVD) hat bekanntgegeben, dass sein COVID-19-Antikörper PEMGARDA® (pemivibart) und der nächste Generationskandidat VYD2311 weiterhin eine starke neutralisierende Wirkung gegen die vorherrschende XFG („Stratus")-Variante von SARS-CoV-2 zeigen. Das Unternehmen berichtet, dass die COVID-19-Fälle zunehmen, mit hoher Virusaktivität in 12 Bundesstaaten und steigenden Infektionszahlen in 34 Bundesstaaten, laut CDC-Daten.
PEMGARDA, von der FDA zur Präexpositionsprophylaxe für bestimmte immungeschwächte Patienten zugelassen, hat seit dem Omicron-Subtyp BA.2 durchgehend Wirksamkeit gegen alle klinischen Varianten gezeigt. Das Unternehmen wird neue in vitro-Neutralisationsdaten an die FDA übermitteln, um sie in das Healthcare Provider Fact Sheet von PEMGARDA aufzunehmen.
- Continued neutralizing activity against dominant XFG variant and other circulating variants
- FDA authorization already secured for PEMGARDA in immunocompromised patients
- Next-generation antibody VYD2311 shows higher potency in testing
- Demonstrated stability of targeted epitopes across SARS-CoV-2 evolution
- Rising COVID-19 cases across the United States may increase urgency for treatment
- Limited to immunocompromised patient population
Insights
Invivyd's antibodies maintain effectiveness against dominant COVID variant amid rising infection wave, validating their technology platform and strategic positioning.
Invivyd's announcement represents significant positive clinical validation for both PEMGARDA (pemivibart), their FDA-authorized monoclonal antibody, and VYD2311, their next-generation candidate. The data confirms continued neutralization against the XFG variant ("Stratus") currently driving COVID-19 infections across America.
What makes this particularly meaningful is the consistent performance across multiple variants (XFG, NB.1.8.1, LF.7.9, LP.8.1), demonstrating the strategic advantage of Invivyd's technology platform in targeting stable viral epitopes that remain structurally intact despite viral evolution. This validates their molecular design strategy and suggests long-term clinical utility that competitors targeting more mutation-prone regions may lack.
The timing is commercially opportune as the CDC reports COVID-19 is growing in 34 states with high viral activity in 12 states' wastewater surveillance. For immunocompromised patients—PEMGARDA's target population—this rising wave represents significant risk.
Most impressive is the company's track record claim that their antibody has maintained effectiveness against every clinical variant since Omicron BA.2, supporting their assertion of anticipated continued protection. For VYD2311, the data suggests similar coverage but with higher potency, potentially enabling more convenient administration and expanded market reach.
The upcoming FDA communication will likely strengthen PEMGARDA's positioning with healthcare providers during this infection surge while building anticipation for VYD2311's advancement, supporting Invivyd's emerging leadership in protecting vulnerable populations from COVID-19's ongoing evolution.
- New in vitro neutralization data show continued, consistent neutralizing activity of PEMGARDA® (pemivibart) against XFG
- Centers for Disease Control data and wastewater surveillance data indicate XFG variant appears to be driving a growing wave of COVID-19 in America
- VYD2311 in vitro neutralization data demonstrate similarly consistent and highly potent results against XFG
- Similar new, positive in vitro neutralization data for pemivibart and VYD2311 against other SARS-CoV-2 viruses currently circulating in the U.S. (NB.1.8.1 (“Nimbus”) and LF.7.9, as well as LP.8.1) affirm Invivyd’s unique technology, reflect consistently stable target epitopes, and indicate ongoing, complete coverage of any tested, relevant SARS-CoV-2 variant by Invivyd’s investigational monoclonal antibodies; no non-responsive viruses identified or anticipated
- Data to be provided to U.S. FDA imminently, with anticipated inclusion in PEMGARDA Fact Sheet for Healthcare Providers
WALTHAM, Mass., Aug. 18, 2025 (GLOBE NEWSWIRE) -- Invivyd, Inc. (Nasdaq: IVVD) today announced positive, continued, clinically meaningful in vitro neutralization data for PEMGARDA® (pemivibart) against the currently dominant and growing XFG variant of SARS-CoV-2. Notably, and consistent with all dominant variants for the past three years, XFG did not generate any meaningful change to the in vitro neutralization activity of pemivibart or VYD2311, the company’s next generation COVID-19 monoclonal antibody (mAb) candidate, as the epitopes targeted by pemivibart and VYD2311 remain structurally intact. PEMGARDA (pemivibart) is authorized by the U.S. Food and Drug Administration (FDA) for pre-exposure prophylaxis of COVID-19 in certain immunocompromised patients.
Currently, the level of COVID-19 viral activity detected in wastewater in 12 states is reported as high or very high levels as of early August, and the U.S. Centers for Disease Control and Prevention (CDC) estimates that COVID-19 infections are growing or likely growing in 34 states and declining in zero states, according to forecasting models. Further, the company estimates that every clinical variant reported in the CDC COVID Data Tracker since the Omicron BA.2 lineage has been susceptible to pemivibart, even if untested, due to the consistent structural integrity of the epitope targeted by pemivibart. Therefore, Invivyd anticipates continued meaningful clinical activity for pemivibart for the foreseeable future if the epitope pemivibart targets remains intact.
“COVID-19 activity is once again on the rise across much of the United States, with wastewater data and forecasting models pointing to sustained growth in infections. Against this backdrop, we are pleased but not surprised that pemivibart has continued to demonstrate neutralizing activity against the currently dominant XFG variant, and we look forward to rapidly advancing our next generation antibody VYD2311 which has shown similar in vitro neutralization results at much higher potency. The demonstrated stability of the epitopes our monoclonal antibodies target across SARS-CoV-2 evolution underscores the strength of our molecular design strategy and our capability in creating high-barrier-to-resistance medicines,” said Robert Allen, Ph.D., Chief Scientific Officer of Invivyd.
“For people whose immune systems may not get enough protection from vaccines such as those on immunosuppressive therapies and those undergoing cancer treatment, each new COVID-19 wave can create additional challenges and disrupt care,” commented Tim Lee, Chief Commercial Officer of Invivyd. “Pemivibart has shown extraordinary continuing in vitro neutralization activity against SARS-CoV-2 over now several years, and our next-generation antibody VYD2311 represents another hopeful step toward more scalable protection with a more patient-friendly route of administration.”
Data showing continued in vitro neutralizing activity of PEMGARDA® (pemivibart) against XFG and other circulating viruses will be provided to the FDA imminently, with anticipated inclusion in the PEMGARDA Fact Sheet for Healthcare Providers.
About PEMGARDA
PEMGARDA® (pemivibart) is a half-life extended investigational monoclonal antibody (mAb). PEMGARDA was engineered from adintrevimab, Invivyd’s investigational mAb that has a robust safety data package and provided evidence of clinical efficacy in global Phase 2/3 clinical trials for the prevention and treatment of COVID-19. PEMGARDA has demonstrated in vitro neutralizing activity against major SARS-CoV-2 variants, including JN.1, KP.3.1.1, XEC and LP.8.1. PEMGARDA targets the SARS-CoV-2 spike protein receptor binding domain (RBD), thereby inhibiting virus attachment to the human ACE2 receptor on host cells.
PEMGARDA (pemivibart) injection (4500 mg), for intravenous use is an investigational mAb that has not been approved, but has been authorized for emergency use by the U.S. FDA under an EUA for the pre-exposure prophylaxis (prevention) of COVID-19 in adults and adolescents (12 years of age and older weighing at least 40 kg) who have moderate-to-severe immune compromise due to certain medical conditions or receipt of certain immunosuppressive medications or treatments and are unlikely to mount an adequate immune response to COVID-19 vaccination. Recipients should not be currently infected with or have had a known recent exposure to an individual infected with SARS-CoV-2.
PEMGARDA is not authorized for use for treatment of COVID-19, treatment of Long COVID, or post-exposure prophylaxis of COVID-19. Pre-exposure prophylaxis with PEMGARDA is not a substitute for vaccination in individuals for whom COVID-19 vaccination is recommended. Individuals for whom COVID-19 vaccination is recommended, including individuals with moderate-to-severe immune compromise who may derive benefit from COVID-19 vaccinations, should receive COVID-19 vaccination. In individuals who have recently received a COVID-19 vaccine, PEMGARDA should be administered at least 2 weeks after vaccination.
Anaphylaxis has been observed with PEMGARDA and the PEMGARDA Fact Sheet for Healthcare Providers includes a boxed warning for anaphylaxis. The most common adverse reactions included systemic infusion-related reactions and hypersensitivity reactions, local infusion site reactions, and infusion site infiltration or extravasation. For additional information, please see the PEMGARDA full product Fact Sheet for Healthcare Providers, including important safety information and boxed warning.
To support the EUA for PEMGARDA, an immunobridging approach was used to determine if PEMGARDA may be effective for pre-exposure prophylaxis of COVID-19. Immunobridging is based on the serum virus neutralizing titer-efficacy relationships identified with other neutralizing human mAbs against SARS-CoV-2. This includes adintrevimab, the parent mAb of pemivibart, and other mAbs that were previously authorized for EUA. There are limitations of the data supporting the benefits of PEMGARDA. Evidence of clinical efficacy for other neutralizing human mAbs against SARS-CoV-2 was based on different populations and SARS-CoV-2 variants that are no longer circulating. Further, the variability associated with cell-based EC50 value determinations, along with limitations related to pharmacokinetic data and efficacy estimates for the mAbs in prior clinical trials, impact the ability to precisely estimate protective titer ranges. Additionally, certain SARS-CoV-2 viral variants may emerge that have substantially reduced susceptibility to PEMGARDA, and PEMGARDA may not be effective at preventing COVID-19 caused by these SARS-CoV-2 viral variants.
The emergency use of PEMGARDA is only authorized for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of drugs and biological products during the COVID-19 pandemic under Section 564(b)(1) of the Federal Food, Drug, and Cosmetic Act, 21 U.S.C. § 360bbb-3(b)(1), unless the declaration is terminated or authorization revoked sooner. PEMGARDA is authorized for use only when the combined national frequency of variants with substantially reduced susceptibility to PEMGARDA is less than or equal to
About VYD2311
VYD2311 is a novel monoclonal antibody (mAb) candidate being developed for COVID-19 to continue to address the urgent need for new prophylactic and therapeutic options. The pharmacokinetic profile and antiviral potency of VYD2311 may offer the ability to deliver clinically meaningful titer levels through more patient-friendly means such as an intramuscular route of administration.
VYD2311 was engineered using Invivyd’s proprietary integrated technology platform and is the product of serial molecular evolution designed to generate an antibody optimized for neutralizing contemporary virus lineages. VYD2311 leverages the same antibody backbone as pemivibart, Invivyd’s investigational mAb granted emergency use authorization in the U.S. for the pre-exposure prophylaxis (PrEP) of symptomatic COVID-19 in certain immunocompromised patients, and adintrevimab, Invivyd’s investigational mAb that has a robust safety data package and demonstrated clinically meaningful results in global Phase 2/3 clinical trials for the prevention and treatment of COVID-19.
About Invivyd
Invivyd, Inc. (Nasdaq: IVVD) is a biopharmaceutical company devoted to delivering protection from serious viral infectious diseases, beginning with SARS-CoV-2. Invivyd deploys a proprietary integrated technology platform unique in the industry designed to assess, monitor, develop, and adapt to create best in class antibodies. In March 2024, Invivyd received emergency use authorization (EUA) from the U.S. FDA for a monoclonal antibody (mAb) in its pipeline of innovative antibody candidates. Visit https://invivyd.com/ to learn more.
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Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “anticipates,” “believes,” “could,” “expects,” “estimates,” “hypothesizes,” “intends,” “potential,” “predicts” “projects,” and “future” or similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) are intended to identify forward-looking statements. Forward-looking statements include statements concerning, among other things, the company’s ongoing research and development activities, as well as future potential research and development efforts; the ongoing in vitro neutralizing activity of PEMGARDA and VYD2311 against dominant SARS-CoV-2 variants; anticipated update to the PEMGARDA Fact Sheet for Healthcare Providers; expectations regarding the COVID-19 landscape and growing U.S. COVID-19 infections; expectations regarding the neutralization activity of pemivibart and VYD2311 for the foreseeable future, and beliefs about the stability of the epitope targeted by pemivibart and VYD2311; expectations about the strength of Invivyd’s molecular design strategy and its capability in creating high-barrier-to-resistance medicines; the potential of PEMGARDA as a mAb for pre-exposure prophylaxis (prevention) of COVID-19 in certain immunocompromised persons; the potential of VYD2311 as a novel mAb candidate that may be able to deliver clinically meaningful titer levels through more patient-friendly means; the company’s devotion to delivering protection from serious viral infectious diseases, beginning with SARS-CoV-2; and other statements that are not historical fact. The company may not actually achieve the plans, intentions or expectations disclosed in the company’s forward-looking statements and you should not place undue reliance on the company’s forward-looking statements. These forward-looking statements involve risks and uncertainties that could cause the company’s actual results to differ materially from the results described in or implied by the forward-looking statements, including, without limitation: the timing, progress and results of the company’s discovery, preclinical and clinical development activities; the risk that results of nonclinical studies or clinical trials may not be predictive of future results, and interim data are subject to further analysis; unexpected safety or efficacy data observed during preclinical studies or clinical trials; the predictability of clinical success of the company’s product candidates based on neutralizing activity in nonclinical studies; potential variability in neutralizing activity of product candidates tested in different assays, such as pseudovirus assays and authentic assays; the company’s reliance on third parties with respect to virus assay creation and product candidate testing; variability of results in models and methods used to predict activity against SARS-CoV-2 variants; whether the epitope that pemivibart and VYD2311 targets remains structurally intact; whether the company’s product candidates are able to demonstrate and sustain neutralizing activity against major SARS-CoV-2 variants, particularly in the face of viral evolution; whether U.S. COVID-19 infections grow as estimated by forecasting models; how long the EUA granted by the FDA for PEMGARDA will remain in effect and whether the EUA is revised or revoked by the FDA; the success of the company’s in-house sales force, and the company’s ability to maintain and expand sales, marketing and distribution capabilities to successfully commercialize PEMGARDA; uncertainties related to the regulatory authorization or approval process, and available development and regulatory pathways for authorization or approval of the company’s product candidates; the ability to maintain a continued acceptable safety, tolerability and efficacy profile of any product candidate following regulatory authorization or approval; changes in the regulatory environment; the outcome of the company’s engagement with regulators; uncertainties related to the regulatory authorization or approval process, and available development and regulatory pathways; changes in expected or existing competition; the complexities of manufacturing mAb therapies; the company’s ability to continue as a going concern; and whether the company has adequate funding to meet future operating expenses and capital expenditure requirements. Other factors that may cause the company’s actual results to differ materially from those expressed or implied in the forward-looking statements in this press release are described under the heading “Risk Factors” in the company’s Annual Report on Form 10-K for the year ended December 31, 2024 and the company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2025, each as filed with the Securities and Exchange Commission (SEC), and in the company’s other filings with the SEC, and in its future reports to be filed with the SEC and available at www.sec.gov. Forward-looking statements contained in this press release are made as of this date, and Invivyd undertakes no duty to update such information whether as a result of new information, future events or otherwise, except as required under applicable law.
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Contacts:
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FAQ
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