Jaguar Health Inc Stock Price, News & Analysis

Jaguar Health (NASDAQ:JAGX) has announced plans to explore an approval pathway for crofelemer in breast and lung cancer based on Phase 3 OnTarget trial results. The company will host a webcast on August 13, 2024, to review Q2 earnings and discuss the trial's clinically meaningful results. Key highlights include:

1. Crofelemer showed promising results for cancer therapy-related diarrhea (CTD) in breast and lung cancer patients.
2. An import permit was granted for a proof-of-concept trial of crofelemer in pediatric patients with rare diseases in Abu Dhabi.
3. Two independent studies on crofelemer for IBS-D have been accepted for presentation at a scientific meeting.
4. Jaguar is pursuing development for rare and orphan diseases, including MVID and SBS.
5. The company is also exploring plant-based medicines for mental health disorders through its Entheogen Therapeutics Initiative.

Jaguar Health (NASDAQ:JAGX) announced that Dr. Elaine Elisabetsky, a member of their Mental Health Entheogen Therapeutics Initiative, will speak at the University of Illinois Chicago College of Pharmacy on August 2, 2024. Her talk will cover decades of research on plant-based medicines for managing schizophrenia.

Dr. Elisabetsky is also an advisor to Magdalena Biosciences, a joint venture between Jaguar and Filament Health. Jaguar recently out-licensed a botanical drug candidate for schizophrenia and psychoses to Magdalena Biosciences. This candidate, sourced from a medicinal plant with traditional use, shows antipsychotic activity with a unique mechanism of action.

The global schizophrenia treatment market, valued at $8.29 billion in 2024, is projected to reach $13.41 billion by 2032. Schizophrenia affects about 1% of the U.S. population, with up to 34% of patients not responding to current treatments.

Jaguar Health (NASDAQ:JAGX) announced positive results from two investigator-initiated studies of crofelemer, its plant-based oral drug, for chronic refractory diarrhea in IBS-D patients. The data will be presented at the American College of Gastroenterology Annual Scientific Meeting in October 2024. Key findings include:

1. In functional diarrhea: Crofelemer significantly decreased stool consistency and abdominal pain without major side effects in a small crossover study of 18 patients.

2. In chronic idiopathic diarrhea: Nearly 60% of patients showed improvement within a 4-week treatment period.

These results suggest crofelemer's potential efficacy in treating subgroups of IBS-D, addressing an unmet need in gastroenterology. The company plans to continue investigating crofelemer for IBS-D management.

Jaguar Health (NASDAQ:JAGX) announced that its subsidiary, Napo Pharmaceuticals, has been granted a new European patent for treating diarrhea associated with congenital diarrheal disorders (CDDs) using crofelemer, a plant-based drug. This patent strengthens Jaguar's intellectual property protection for its core rare disease target indication, particularly for microvillus inclusion disease (MVID), an ultrarare CDD.

The company is supporting investigator-initiated proof-of-concept studies for crofelemer in treating short bowel syndrome (SBS) and MVID across the US, EU, and Middle East/North Africa regions. Results are expected by the end of 2024 and throughout 2025. Jaguar now holds approximately 200 patents issued and pending, with crofelemer being the only oral plant-based prescription medicine approved under the FDA's Botanical Guidance.

Jaguar Health (NASDAQ:JAGX) announced results from its Phase 3 OnTarget trial of crofelemer for prophylaxis of diarrhea in adult cancer patients with solid tumors receiving targeted therapy. The trial did not meet its primary endpoint across all tumor types. However, it revealed clinically relevant signals for crofelemer in prespecified subgroups of patients with breast and respiratory cancer, including lung cancer. These subgroups comprised over 75% of trial participants.

Key takeaways:

• Trial included 10 tumor types and 24 targeted agents
• Positive signals improved over the initial 12-week phase
• Crofelemer was well-tolerated with an adverse event profile similar to placebo
• Company plans to engage with FDA after full data review

Jaguar will host an investor webcast on July 23, 2024, to provide updates on its cancer supportive care portfolio.

Jaguar Health (NASDAQ:JAGX) will report results of its Phase 3 OnTarget trial for crofelemer, a cancer supportive care drug, on July 23, 2024. The company will hold an investor webcast at 8:30 AM Eastern to discuss the results and provide updates on its cancer supportive care portfolio. The webcast will feature Jaguar's scientific team, patient advocates, and oncology experts focusing on cancer therapy-related diarrhea (CTD) and oral mucositis.

Jaguar has expanded its 'Make Cancer Less Shitty' (MCLS) patient advocacy program, incorporating MCLS Ambassadors who are cancer survivors. The company also entered a 5-year U.S. in-license agreement for Gelclair, an FDA-approved oral mucositis product. These initiatives aim to address the significant impact of treatment side effects on cancer patients' quality of life and treatment adherence.

Jaguar Health has announced the issuance of new patents in Europe and Australia to bolster IP protection for its drug crofelemer, aimed at treating Short Bowel Syndrome (SBS) and Congenital Diarrheal Disorders (CDDs). The European patent covers treatment methods for SBS and associated conditions, while the Australian patent focuses on CDDs. The patents enhance Jaguar's intellectual property portfolio, which already includes approximately 200 patents issued or pending. This development supports ongoing proof-of-concept studies of crofelemer in the US, EU, and MENA regions, with results expected in 2024 and 2025. These studies could facilitate early patient access to crofelemer in countries with applicable guidelines. SBS and MVID patients suffer from severe symptoms requiring intensive medical support, highlighting the potential impact of these patents on patient care.

Jaguar Health (NASDAQ: JAGX) has announced that it has regained compliance with Nasdaq's bid price requirement as of June 25, 2024, ensuring its securities remain listed and traded on Nasdaq. The company is also set to report results from its pivotal phase 3 OnTarget trial for the cancer supportive care drug crofelemer by July 23, 2024. Jaguar's CEO, Lisa Conte, emphasized the importance of maintaining their Nasdaq listing and mentioned an upcoming investor webcast that will discuss Jaguar's cancer supportive care portfolio, featuring insights from scientific experts and patient advocates.

Jaguar Health announced the approval of all proposals at its Annual Meeting of Stockholders held on June 21, 2024. Five proposals were submitted and approved, details of which are available in the company's proxy statement filed with the SEC. Jaguar will report results from its pivotal phase 3 OnTarget trial for the cancer supportive care drug crofelemer by July 23, 2024. An investor webcast on or before this date will include updates on Jaguar's cancer supportive care portfolio, featuring insights from the scientific team, patient advocates, and oncology experts. In celebration of World Rainforest Day on June 22, Jaguar shared a RealPharma podcast interview with Dr. Steven King, highlighting his ethnobotanical research and the medicinal use of plants by indigenous Amazonian communities.