Kiniksa Pharmaceuticals Reports Third Quarter 2026 Financial Results and Recent Portfolio Execution
The raised ARCALYST sales outlook accompanies higher earnings and increased spending on commercialization and clinical development.
Sentiment and the balance of points
Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.
Rhea-AI Summary
Kiniksa Pharmaceuticals (Nasdaq: KNSA) reported third-quarter 2026 ARCALYST net product revenue of $286.0 million, representing approximately 58% year-over-year growth. Net income rose to $47.3 million from $18.4 million, while diluted earnings per share increased to $0.56 from $0.23. Kiniksa raised its expected 2026 ARCALYST revenue to $1.045–$1.050 billion, from $980–$995 million.
Cash, cash equivalents and short-term investments totaled $568.8 million at September 30, with no debt. Quarterly operating expenses increased to $231.7 million from $156.8 million. Kiniksa expects its operating plan to remain cash flow positive annually. Enrollment and dosing continue in the pivotal KPL-387 PASTORALE trial, with data expected in the second half of 2027. The company expects to begin a first-in-human KPL-1161 trial by the end of 2026.
How this balance works
Rhea-AI gives every point it takes from this document a weight. Minor counts 1, Moderate 3 and Major 9, so one Major point outweighs several Minor ones. The bar adds up the weights on each side, and when neither side holds more than 65% of the total the balance reads Mixed.
It reads the document as published, with the same rules for every company, and it does not look at what the market expected or at how the stock traded, so a point can be objectively good on a day the stock falls.
Rhea-AI Sentiment measures something else, the tone of the wording.
Hollow bars mark forward-looking points. How the balance works
Positive
- Major point. Forward-looking: it has not happened yet and may not happen.Kiniksa raised expected 2026 ARCALYST revenue to $1.045–$1.050 billion from $980–$995 million.
- Moderate pointARCALYST Q3 2026 net revenue reached $286.0 million, approximately 58% above Q3 2025.
- Moderate pointQ3 2026 net income increased to $47.3 million from $18.4 million in Q3 2025.
- Moderate pointCash, equivalents and short-term investments rose to $568.758 million at September 30, from $414.074 million at December 31, 2025.
- Moderate point. Forward-looking: it has not happened yet and may not happen.Kiniksa expects its current operating plan to remain cash flow positive on an annual basis.
15 minor points
- Minor pointQ3 2026 diluted earnings per share rose to $0.56 from $0.23 a year earlier.
- Minor pointQ3 2026 operating income increased to $54.236 million from $24.021 million in Q3 2025.
- Minor pointNine-month 2026 revenue increased to $743.836 million from $475.437 million a year earlier.
- Minor pointNine-month 2026 net income increased to $95.369 million from $44.806 million a year earlier.
- Minor pointNine-month 2026 diluted earnings per share increased to $1.14 from $0.57 a year earlier.
- Minor pointNine-month 2026 operating income increased to $110.697 million from $57.453 million a year earlier.
- Minor pointKiniksa had no debt at September 30, 2026.
- Minor pointWorking capital increased to $558.244 million at September 30, from $387.993 million at December 31, 2025.
- Minor pointShareholders’ equity increased to $710.193 million at September 30, from $567.606 million at December 31, 2025.
- Minor pointARCALYST treated approximately 23% of 14,000 annual multiple-recurrence patients at the end of Q3 2026.
- Minor pointARCALYST prescriptions for recurrent pericarditis have come from more than 5,450 prescribers since launch.
- Minor point. Forward-looking: it has not happened yet and may not happen.KPL-387 pivotal Phase 3 enrollment and dosing continue; Kiniksa expects data in the second half of 2027.
- Minor pointKiniksa is conducting a supplemental Phase 2 study of transitions from standard therapies to KPL-387 alone.
- Minor point. Forward-looking: it has not happened yet and may not happen.Kiniksa targets bringing KPL-387 to patients in the 2028/2029 timeframe.
- Minor point. Forward-looking: it has not happened yet and may not happen.Kiniksa expects to initiate KPL-1161’s first-in-human Phase 1 trial by the end of 2026.
Negative
- Moderate pointQ3 2026 collaboration expenses increased to $105.8 million from $63.3 million a year earlier.
- Minor pointQ3 2026 selling, general and administrative expenses increased to $65.4 million from $49.1 million a year earlier.
- Minor pointQ3 2026 research and development expenses increased to $32.8 million from $24.2 million a year earlier.
- Minor pointQ3 2026 cost of goods sold increased to $27.8 million from $20.3 million a year earlier.
- Minor point. Forward-looking: it has not happened yet and may not happen.Kiniksa expects 2026 research and development expenses of $160–$170 million.
- Minor point. Forward-looking: it has not happened yet and may not happen.Kiniksa expects 2026 selling, general and administrative expenses of $270–$280 million.
News Explained
At the end of the third quarter, Kiniksa reported that approximately
Details
Market move: KNSA +17.05% vs previous close. Q3 2026 earnings report
On Oct 27, the day this news came out, the latest delayed price for KNSA is 17.05% above the previous close. Our momentum scanner has recorded 9 alerts for this stock so far that day. The latest delayed price is $85.42. Relative volume is exceptionally heavy at 34.9x the average.
Data tracked by StockTitan Argus (15 min delayed). Upgrade to Gold for real-time data.
Key Figures
- ARCALYST net product revenue
- $286.0 million; ~58% year-over-year growth
- Q3 2026
- 2026 ARCALYST revenue guidance
- $1.045–$1.050 billion
- Raised from prior guidance of $980–$995 million
- Net income
- $47.3 million vs. $18.4 million
- Q3 2026 vs. Q3 2025
- Cash and debt
- $568.8 million; no debt
- As of September 30, 2026
- KPL-387 Phase 3 data
- Expected in 2H 2027
- PASTORALE pivotal trial
Previous Earnings Reports
-
Q2 results raised ARCALYST guidance to $980–$995 million and advanced PASTORALE into Phase 3 enrollment.
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Key Terms
monoclonal antibody medical
subcutaneous medical
randomized withdrawal medical
primary efficacy endpoint medical
orphan drug designation regulatory
AI-generated analysis. How Rhea-AI works. Not financial advice.
– ARCALYST® (rilonacept) Q3 2026 net product revenue of
– ARCALYST 2026 expected net product revenue increased to
– KPL-387 pivotal Phase 3 data expected in 2H 2027 –
– Conference call and webcast scheduled for 8:30 am ET today –
LONDON, Oct. 27, 2026 (GLOBE NEWSWIRE) -- Kiniksa Pharmaceuticals International, plc (Nasdaq: KNSA) (Kiniksa), a biopharmaceutical company developing and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications, today reported third quarter 2026 financial results and recent portfolio execution.
“Kiniksa continues to build a leading IL-1α and IL-1β inhibition franchise, driven by the commercialization of ARCALYST in recurrent pericarditis. In the third quarter, strong commercial execution led to gains in patient and physician adoption, resulting in revenue of
Portfolio Execution
ARCALYST (IL-1α and IL-1β cytokine trap)
- ARCALYST net product revenue was
$286.0 million for the third quarter of 2026. - As of the end of the third quarter of 2026, approximately
23% of the 14,000 annual multiple-recurrence patients were actively on ARCALYST treatment. - Since launch, more than 5,450 prescribers have written ARCALYST prescriptions for recurrent pericarditis.
- As of the end of the third quarter of 2026, average total duration of ARCALYST therapy in recurrent pericarditis was approximately 3 years, in line with the median duration of disease.
KPL-387 (monoclonal antibody IL-1 receptor antagonist)
- Kiniksa is enrolling and dosing patients in the Phase 3 pivotal trial of KPL-387 in recurrent pericarditis, PASTORALE, and expects data in the second half of 2027.
- Kiniksa is also conducting a supplemental Phase 2 Transition to KPL-387 Monotherapy Dosing and Administration Study evaluating the transition of patients from standard therapies to KPL-387 monotherapy.
KPL-1161 (Fc-modified monoclonal antibody IL-1 receptor antagonist)
- Kiniksa expects to initiate a Phase 1 first-in-human clinical trial of KPL-1161 with a target profile of quarterly subcutaneous (SC) dosing by the end of 2026.
Financial Results
- Total revenue for the third quarter of 2026 was
$286.0 million , compared to$180.9 million for the third quarter of 2025. - Total operating expenses for the third quarter of 2026 were
$231.7 million , compared to$156.8 million for the third quarter of 2025, and comprised the following:- Cost of Goods Sold (COGS) expenses of
$27.8 million , compared to$20.3 million for the third quarter of 2025. The increase in COGS expenses was primarily due to costs associated with increased sales of ARCALYST. - Collaboration expenses of
$105.8 million , compared to$63.3 million for the third quarter of 2025. Collaboration expenses are driven primarily by ARCALYST collaboration profitability. - Research and Development (R&D) expenses of
$32.8 million , compared to$24.2 million for the third quarter of 2025. The increase in R&D expenses was primarily due to increased KPL-387 clinical activity. - Selling, General, and Administrative (SG&A) expenses of
$65.4 million , compared to$49.1 million for the third quarter of 2025. The increase in SG&A expenses was primarily due to investment associated with the commercialization of ARCALYST. - Total operating expenses for the third quarter of 2026 included
$13.1 million in non-cash, share-based compensation expense, compared to$10.1 million for the third quarter of 2025.
- Cost of Goods Sold (COGS) expenses of
- Net income for the third quarter of 2026 was
$47.3 million , compared to$18.4 million for the third quarter of 2025. - As of September 30, 2026, Kiniksa had
$568.8 million of cash, cash equivalents, and short-term investments and no debt.
Financial Guidance
- Kiniksa expects 2026 ARCALYST net product revenue of between
$1.045 billion and$1.050 billion , compared to prior guidance of between$980 million and$995 million . - Kiniksa expects 2026 R&D expenses of between
$160 million and$170 million and 2026 SG&A expenses of between$270 million and$280 million . - Kiniksa expects its current operating plan to remain cash flow positive on an annual basis.
Conference Call Information
- Kiniksa will host a conference call and webcast at 8:30 a.m. Eastern Time on Tuesday, October 27, 2026, to discuss third quarter 2026 financial results and recent portfolio execution.
- Individuals interested in participating in the call via telephone may register here. Upon registration, all telephone participants will receive a confirmation email detailing how to join the conference call, including the dial-in number along with a unique passcode and registrant ID that can be used to access the call. To access the webcast, please visit the Investors and Media section of Kiniksa’s website. A replay of the event will also be available on Kiniksa’s website within approximately 48 hours after the event.
About Kiniksa
Kiniksa is a biopharmaceutical company dedicated to improving the lives of patients suffering from debilitating diseases by discovering, acquiring, developing, and commercializing novel therapies for diseases with unmet need, with a focus on cardiovascular indications. Kiniksa’s portfolio of assets is based on strong biologic rationale or validated mechanisms and offers the potential for differentiation. For more information, please visit www.kiniksa.com.
About ARCALYST
ARCALYST is a weekly, subcutaneously injected recombinant dimeric fusion protein that blocks interleukin-1 alpha (IL-1α) and interleukin-1 beta (IL-1β) signaling. ARCALYST was discovered by Regeneron Pharmaceuticals, Inc. (Regeneron) and is approved by the U.S. Food and Drug Administration (FDA) for recurrent pericarditis, cryopyrin-associated periodic syndromes (CAPS), including Familial Cold Autoinflammatory Syndrome and Muckle-Wells Syndrome, and deficiency of IL-1 receptor antagonist (DIRA). The FDA granted Breakthrough Therapy designation to ARCALYST for the treatment of recurrent pericarditis in 2019 and Orphan Drug exclusivity to ARCALYST in 2021 for the treatment of recurrent pericarditis and reduction in risk of recurrence in adults and pediatric patients 12 years and older. The European Commission granted Orphan Drug Designation to ARCALYST for the treatment of idiopathic pericarditis in 2021.
IMPORTANT SAFETY INFORMATION ABOUT ARCALYST
- ARCALYST may affect your immune system and can lower the ability of your immune system to fight infections. Serious infections, including life-threatening infections and death, have happened in patients taking ARCALYST. If you have any signs of an infection, call your doctor right away. Treatment with ARCALYST should be stopped if you get a serious infection. You should not begin treatment with ARCALYST if you have an infection or have infections that keep coming back (chronic infection).
- While taking ARCALYST, do not take other medicines that block interleukin-1, such as Kineret® (anakinra), or medicines that block tumor necrosis factor, such as Enbrel® (etanercept), Humira® (adalimumab), or Remicade® (infliximab), as this may increase your risk of getting a serious infection.
- Talk with your doctor about your vaccine history. Ask your doctor whether you should receive any vaccines before you begin treatment with ARCALYST.
- Medicines that affect the immune system may increase the risk of getting cancer.
- Stop taking ARCALYST and call your doctor or get emergency care right away if you have any symptoms of an allergic reaction.
- Your doctor will do blood tests to check for changes in your blood cholesterol and triglycerides.
- Common side effects include injection-site reactions (which may include pain, redness, swelling, itching, bruising, lumps, inflammation, skin rash, blisters, warmth, and bleeding at the injection site), upper respiratory tract infections, joint and muscle aches, rash, ear infection, sore throat, and runny nose.
For more information about ARCALYST, talk to your doctor and see the Product Information.
About KPL-387
KPL-387 is an independently developed, investigational, fully human immunoglobulin G2 (IgG2) monoclonal antibody that binds human interleukin-1 receptor 1 (IL-1R1), inhibiting the signaling of the cytokines IL-1α and IL-1β. Kiniksa believes KPL-387 could expand the treatment options for recurrent pericarditis patients by potentially enabling dosing with a single monthly SC self-injection in a liquid formulation. In October 2025, the FDA granted Orphan Drug Designation to KPL-387 for the treatment of pericarditis.
About PASTORALE
PASTORALE is a double-blind, placebo controlled, randomized withdrawal (RW) study enrolling up to approximately 85 patients with recurrent pericarditis. In the first period, a single-blind run-in (RI), all participants will receive KPL-387 while conventional oral pericarditis medications are weaned and discontinued. Participants achieving Clinical Response in the RI period will then be randomized in a 1:1 ratio to receive either KPL-387 300 mg SC once-monthly or placebo in an event-driven, double-blind, RW period. The primary efficacy endpoint is time to first-adjudicated pericarditis recurrence during the RW period. Participants in the RW period may be eligible to enter a long-term extension.
About KPL-1161
KPL-1161 is an independently developed, investigational, Fc-modified IgG2 monoclonal antibody that binds IL-1R1, inhibiting the signaling of the cytokines IL-1α and IL-1β, with a target profile of quarterly SC dosing. Kiniksa is currently engaging in preclinical development activities for KPL-1161.
Forward-Looking Statements
This press release contains forward-looking statements. In some cases, you can identify forward looking statements by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or the negative of these terms or other similar expressions, although not all forward-looking statements contain these identifying words. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation, statements regarding: our expectation that ARCALYST will achieve blockbuster status in 2026 with net product revenue between
These forward-looking statements are based on management’s current expectations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including without limitation, the following: delays or difficulty in enrollment of patients in, and activation or continuation of sites for, our clinical trials; delays or difficulty in completing our clinical trials as originally designed; potential for changes between final data and any preliminary, interim, top-line or other data from clinical trials, including the data from our ongoing clinical trials of KPL-387 in recurrent pericarditis; our inability to replicate results from our earlier clinical trials or studies; impact of additional data from us or other companies, including the potential for our data to produce negative, inconclusive or commercially uncompetitive results; our reliance on third parties to conduct research, clinical trials, and/or certain regulatory activities for our product candidates; complications in coordinating requirements, regulations and guidelines of regulatory authorities across jurisdictions for our clinical trials; potential undesirable side effects caused by our products and product candidates; our inability to demonstrate safety and efficacy to the satisfaction of applicable regulatory authorities; potential for applicable regulatory authorities to not accept our filings, delay or deny approval of any of our product candidates or require additional data or trials to support approval; our reliance on third parties as the sole source of supply of the drug substance and drug product used in our products and product candidates; raw material, important ancillary product and drug substance and/or drug product shortages; business development activities and their impact on our financial performance and strategy; changes in our operating plan, business development strategy or funding requirements; existing or new competition; current and future healthcare reforms, including those affecting the delivery of or payment for healthcare products and services; and the impact of global economic policy, including any uncertainty in national and international markets.
These and other important factors discussed in our filings with the U.S. Securities and Exchange Commission, including under the caption “Risk Factors” contained therein, could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. Except as required by law, we disclaim any intention or obligation to update or revise any forward-looking statements. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.
ARCALYST® is a registered trademark of Regeneron Pharmaceuticals, Inc.
Every Second Counts! ®
Kiniksa Investor & Media Contact
Jonathan Kirshenbaum
(781) 829-3949
jkirshenbaum@kiniksa.com
| KINIKSA PHARMACEUTICALS INTERNATIONAL, PLC | ||||||||||||||||||||||
| SELECTED CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS | ||||||||||||||||||||||
| (In thousands, except share and per share amounts) | ||||||||||||||||||||||
| (Unaudited) | ||||||||||||||||||||||
| Three Months Ended | Nine Months Ended | |||||||||||||||||||||
| September 30, | September 30, | |||||||||||||||||||||
| 2026 | 2025 | 2026 | 2025 | |||||||||||||||||||
| Revenue: | ||||||||||||||||||||||
| Product revenue, net | $ | 285,970 | $ | 180,855 | $ | 743,836 | $ | 475,437 | ||||||||||||||
| License and collaboration revenue | — | — | — | — | ||||||||||||||||||
| Total revenue | 285,970 | 180,855 | 743,836 | 475,437 | ||||||||||||||||||
| Operating expenses: | ||||||||||||||||||||||
| Cost of goods sold | 27,759 | 20,257 | 72,127 | 56,728 | ||||||||||||||||||
| Collaboration expenses | 105,828 | 63,307 | 269,474 | 159,515 | ||||||||||||||||||
| Research and development | 32,786 | 24,166 | 101,160 | 62,244 | ||||||||||||||||||
| Selling, general and administrative | 65,361 | 49,104 | 190,378 | 139,497 | ||||||||||||||||||
| Total operating expenses | 231,734 | 156,834 | 633,139 | 417,984 | ||||||||||||||||||
| Income from operations | 54,236 | 24,021 | 110,697 | 57,453 | ||||||||||||||||||
| Other income, net | 4,821 | 3,136 | 12,186 | 8,146 | ||||||||||||||||||
| Income before income taxes | 59,057 | 27,157 | 122,883 | 65,599 | ||||||||||||||||||
| Provision for income taxes | (11,712 | ) | (8,722 | ) | (27,514 | ) | (20,793 | ) | ||||||||||||||
| Net income | $ | 47,345 | $ | 18,435 | $ | 95,369 | $ | 44,806 | ||||||||||||||
| Net income per share attributable to ordinary shareholders—basic | $ | 0.61 | $ | 0.25 | $ | 1.23 | $ | 0.61 | ||||||||||||||
| Net income per share attributable to ordinary shareholders—diluted | $ | 0.56 | $ | 0.23 | $ | 1.14 | $ | 0.57 | ||||||||||||||
| Weighted average ordinary shares outstanding—basic | 78,192,603 | 74,714,846 | 77,435,077 | 73,605,690 | ||||||||||||||||||
| Weighted average ordinary shares outstanding—diluted | 84,920,060 | 80,035,400 | 83,713,015 | 78,027,370 | ||||||||||||||||||
| KINIKSA PHARMACEUTICALS INTERNATIONAL, PLC | ||||||||||||||
| SELECTED CONDENSED CONSOLIDATED BALANCE SHEET DATA | ||||||||||||||
| (In thousands) | ||||||||||||||
| (Unaudited) | ||||||||||||||
| As of | ||||||||||||||
| September 30, | December 31, | |||||||||||||
| 2026 | 2025 | |||||||||||||
| Cash, cash equivalents, and short-term investments | $ | 568,758 | $ | 414,074 | ||||||||||
| Working capital | 558,244 | 387,993 | ||||||||||||
| Total assets | 983,243 | 763,633 | ||||||||||||
| Accumulated deficit | (366,769 | ) | (462,138 | ) | ||||||||||
| Total shareholders' equity | 710,193 | 567,606 | ||||||||||||
FAQ
AI-generated questions and answers. How Rhea-AI works. Not financial advice.
What is Kiniksa’s updated 2026 ARCALYST revenue guidance?
Kiniksa expects 2026 ARCALYST net product revenue of $1.045 billion to $1.050 billion, up from its prior range of $980 million to $995 million. Third-quarter 2026 ARCALYST revenue was $286.0 million, representing approximately 58% year-over-year growth.
When does Kiniksa expect KPL-387 Phase 3 results?
Kiniksa expects data from the pivotal PASTORALE Phase 3 trial in the second half of 2027. The trial is enrolling and dosing patients with recurrent pericarditis.
What does Kiniksa’s PASTORALE trial measure, and how is it designed?
PASTORALE’s primary efficacy measure is time to first independently adjudicated pericarditis recurrence during the randomized withdrawal period. The study enrolls up to approximately 85 patients. Participants first receive KPL-387 while conventional oral medications are withdrawn; those achieving Clinical Response are randomized 1:1 to KPL-387 300 mg once monthly by injection under the skin or placebo.
Why did Kiniksa’s third-quarter 2026 operating costs increase?
Higher ARCALYST sales, commercialization investment and increased KPL-387 clinical activity contributed to higher operating costs. Cost of goods sold increased primarily with ARCALYST sales, research spending increased primarily with KPL-387 clinical activity, and selling and administrative spending increased primarily with ARCALYST commercialization investment. Collaboration expenses are driven primarily by ARCALYST collaboration profitability.