Welcome to our dedicated page for Karyopharm Therapeutics news (Ticker: KPTI), a resource for investors and traders seeking the latest updates and insights on Karyopharm Therapeutics stock.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company focused on novel cancer therapies that target nuclear export dysregulation. Its lead product, XPOVIO (selinexor), is a first-in-class, oral exportin 1 (XPO1) inhibitor approved in the U.S. in multiple oncology indications and in various indications across more than 50 ex-U.S. territories and countries, according to company statements.
This news page aggregates company-issued updates and market disclosures related to Karyopharm. Readers can follow announcements on XPOVIO commercial performance, such as reported U.S. net product revenue and trends in license and royalty revenue from international partners, as described in the company’s earnings releases. The feed also covers progress in Karyopharm’s clinical pipeline, including multiple myeloma, endometrial cancer, myelofibrosis and diffuse large B-cell lymphoma (DLBCL).
Recent news has highlighted key milestones in late-stage development, including completion of enrollment in the Phase 3 SENTRY trial (XPORT-MF-034) in myelofibrosis and ongoing enrollment in the global Phase 3 XPORT-EC-042 trial in TP53 wild-type advanced or recurrent endometrial cancer. Company releases also describe Phase 2 data in heavily pretreated myelofibrosis patients and the design of additional studies such as SENTRY-2 and XPORT-MM-031 in multiple myeloma.
In addition to clinical and commercial updates, Karyopharm’s news includes financial results, preliminary revenue disclosures, strategic financing transactions involving term loans and convertible notes, and inducement equity awards granted under its inducement stock incentive plan. Investors and observers can use this page to review the company’s own descriptions of its operational progress, financing activities and anticipated clinical catalysts as reported in press releases and referenced in SEC filings.
Karyopharm Therapeutics (Nasdaq: KPTI) announced the completion of patient recruitment for the Phase 3 SIENDO study, evaluating selinexor for front-line maintenance therapy in advanced or recurrent endometrial cancer. With over 250 patients enrolled, the study aims to show improved progression-free survival rates. There are currently no approved maintenance therapies for this cancer type. Karyopharm expects to report top-line data by year-end 2021 or early 2022, which could demonstrate selinexor's therapeutic potential and impact future treatment options.
Karyopharm Therapeutics (Nasdaq: KPTI) announced on December 1, 2021, that its Compensation Committee granted stock options for 68,900 shares to 13 new employees, effective November 30, 2021. The options have an exercise price of $6.95 per share, equal to the closing price on the grant date. Each option vests over four years, with 25% vesting after one year, and can be exercised immediately upon termination under certain conditions. This move is part of Karyopharm's strategy to attract talent as it develops novel cancer therapies.
Karyopharm Therapeutics (Nasdaq: KPTI) will host a virtual Investor Day on December 8, 2021, from 10:00 a.m. to 12:30 p.m. ET. The event will feature Karyopharm's executive team and six experts in oncology to discuss commercial opportunities and pipeline priorities. Attendees can join via phone or view a live webcast on the company’s website. Karyopharm specializes in cancer therapies, notably its lead drug XPOVIO®, approved for several hematologic cancers. The event aims to outline the company's vision and milestones.
Karyopharm Therapeutics (Nasdaq: KPTI) announced participation in the Jefferies London Healthcare Conference with CEO Richard Paulson hosting a fireside chat. The discussion will be available for on-demand listening starting November 18, 2021, at 3:00 a.m. Eastern Time. A replay will be accessible for 30 days on the company's investor website.
Karyopharm is focused on developing innovative cancer therapies, particularly through its XPOVIO® (selinexor) compound, which is approved for multiple hematologic malignancies.
Karyopharm Therapeutics (KPTI) announced new data from a Phase 2 study of selinexor, an oral SINE compound for myelofibrosis patients previously treated with JAK inhibitors. The study showed a 33% response rate, with significant spleen volume reduction and improved anemia status. Despite ruxolitinib's poor prognosis (14 months survival), selinexor demonstrated durable responses and a well-tolerated safety profile. Karyopharm plans to initiate a new Phase 2 study evaluating selinexor against physician's choice in late 2021. Results will be presented at the ASH 2021 meeting from December 11-14.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) reported third-quarter 2021 financial results, revealing net product revenue of $26.7 million, a 32% increase from the previous quarter and 25% growth year-over-year. The company highlighted its commercial success with XPOVIO, moving into earlier treatment lines for multiple myeloma. R&D expenses rose to $45.8 million, while the net loss was $51.8 million or $0.69 per share. Karyopharm expects a cash runway into mid-2023, with key upcoming milestones including Phase 3 data from the SIENDO study in endometrial cancer.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) announced the granting of stock options for 171,300 shares to 15 newly-hired employees as of October 29, 2021. This grant, compliant with Nasdaq Listing Rule 5635(c)(4), includes a stock option exercise price of $5.46 per share. The options vest over four years, with 25% vesting at the one-year mark. In instances of a "change in control event," the options are immediately exercisable if employment is terminated for "good reason" or without "cause." Karyopharm specializes in innovative cancer therapies, notably its lead compound, XPOVIO®.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) will report its third quarter 2021 financial results on November 3, 2021. The company's management will host a conference call at 8:30 a.m. ET on the same day to discuss results and updates. Karyopharm focuses on innovative cancer therapies, notably its lead compound, XPOVIO® (selinexor), which is approved for multiple hematologic malignancies in the U.S. and has received conditional authorization in Europe. For details, visit the investor section.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) announced that the first patient has been dosed in the Phase 2 expansion study evaluating eltanexor for myelodysplastic syndrome (MDS). This follows promising Phase 1 results showing a 53% overall response rate and a median overall survival of 9.9 months in high-risk, relapsed MDS patients. The Phase 2 expansion aims to assess eltanexor monotherapy in HMA-refractory MDS patients, with the overall response rate as the primary endpoint. Eltanexor is part of a new approach targeting nuclear export to treat various cancers.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) announced the grant of stock options to 21 newly-hired employees as an inducement for joining the company, in compliance with Nasdaq Listing Rule 5635(c)(4). A total of 147,300 shares were awarded, with an exercise price of $5.82 per share, reflecting the stock's closing price on September 30, 2021. The options vest over four years, with a portion becoming immediately exercisable under specific conditions related to employment termination. Karyopharm specializes in pioneering cancer therapies, including its lead compound, XPOVIO®.
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