Welcome to our dedicated page for Karyopharm Therapeutics news (Ticker: KPTI), a resource for investors and traders seeking the latest updates and insights on Karyopharm Therapeutics stock.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company focused on novel cancer therapies that target nuclear export dysregulation. Its lead product, XPOVIO (selinexor), is a first-in-class, oral exportin 1 (XPO1) inhibitor approved in the U.S. in multiple oncology indications and in various indications across more than 50 ex-U.S. territories and countries, according to company statements.
This news page aggregates company-issued updates and market disclosures related to Karyopharm. Readers can follow announcements on XPOVIO commercial performance, such as reported U.S. net product revenue and trends in license and royalty revenue from international partners, as described in the company’s earnings releases. The feed also covers progress in Karyopharm’s clinical pipeline, including multiple myeloma, endometrial cancer, myelofibrosis and diffuse large B-cell lymphoma (DLBCL).
Recent news has highlighted key milestones in late-stage development, including completion of enrollment in the Phase 3 SENTRY trial (XPORT-MF-034) in myelofibrosis and ongoing enrollment in the global Phase 3 XPORT-EC-042 trial in TP53 wild-type advanced or recurrent endometrial cancer. Company releases also describe Phase 2 data in heavily pretreated myelofibrosis patients and the design of additional studies such as SENTRY-2 and XPORT-MM-031 in multiple myeloma.
In addition to clinical and commercial updates, Karyopharm’s news includes financial results, preliminary revenue disclosures, strategic financing transactions involving term loans and convertible notes, and inducement equity awards granted under its inducement stock incentive plan. Investors and observers can use this page to review the company’s own descriptions of its operational progress, financing activities and anticipated clinical catalysts as reported in press releases and referenced in SEC filings.
Karyopharm Therapeutics (Nasdaq: KPTI), a company focused on innovative cancer therapies, will have CEO Michael Kauffman participate in two virtual investor conferences. The SVB Leerink 10th Annual Global Healthcare Conference is scheduled for February 24, 2021, at 1:00 PM ET, while the Barclays Global Healthcare Conference will take place on March 9, 2021, at 9:10 AM ET. Live webcasts will be available on Karyopharm's website, with replays accessible for 30 days post-event.
Karyopharm Therapeutics (KPTI) reported fourth quarter 2020 net product revenue of $20.2 million, a 5% decline from Q3 2020, attributed to COVID-19 impacts and increased competition. The company achieved FDA approval for XPOVIO in additional oncology indications, expanding its market potential. Total revenue for 2020 was $76.2 million, a significant increase from $30.5 million in 2019. However, the net loss for Q4 was $43.4 million, an improvement from Q4 2019. Karyopharm maintains a strong cash position of $276.7 million as it looks ahead to 2021.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) will announce its fourth quarter and full year 2020 financial results on February 11, 2021. A conference call will be hosted by the management team at 8:30 a.m. ET to discuss these results and provide company updates. Karyopharm specializes in innovative cancer therapies, including its lead drug, XPOVIO® (selinexor), which has multiple U.S. approvals for various hematologic malignancies. A Marketing Authorization Application for selinexor is also under review by the European Medicines Agency.
Karyopharm Therapeutics (Nasdaq: KPTI) announced that Promedico Ltd. has received approval from the Israeli Ministry of Health for XPOVIO® (selinexor) to treat multiple myeloma and diffuse large B-cell lymphoma (DLBCL). The approved use includes XPOVIO combined with dexamethasone for adult patients with relapsed refractory multiple myeloma who have undergone at least three therapies and for those with relapsed or refractory DLBCL post two systemic therapies. Karyopharm anticipates further registration in Israel by Q2 2021 and awaits a European Commission decision on NEXPOVIO® by April 2021.
Karyopharm Therapeutics (Nasdaq: KPTI) announced on February 1, 2021, that its Compensation Committee granted stock options for 165,500 shares to 31 new employees as an inducement for joining the company. The stock options have an exercise price of $15.23, equal to the closing stock price on January 29, 2021, and will vest over four years. They will be immediately exercisable under certain conditions related to employment termination. KPTI develops novel cancer therapies, with its lead drug, XPOVIO®, approved in various hematologic malignancy indications.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) announced that the European Medicines Agency's CHMP has issued a positive opinion recommending conditional approval for NEXPOVIO® (selinexor) in combination with dexamethasone for treating multiple myeloma in patients with extensive prior therapy. This recommendation is a critical step toward a final decision by the European Commission, expected by April 2021. The MAA is supported by the Phase 2b STORM study, showing a 26% overall response rate in heavily pretreated patients. Karyopharm plans to expand its regulatory filing based on additional study data.
Karyopharm Therapeutics (Nasdaq: KPTI) reported preliminary unaudited revenue estimates for Q4 and full year 2020, expecting total revenues of $35-$36 million for the fourth quarter and $108-$109 million for the year. Net product sales for XPOVIO are estimated between $20-$20.5 million for Q4 and $76-$76.5 million for the year. A decline in sales was noted, attributed to COVID-19 impacts and increased competition. The company entered a distribution agreement for XPOVIO in Canada, generating $15 million in license revenue. The cash position increased to $277 million by year-end 2020.
Karyopharm Therapeutics (Nasdaq: KPTI) announced stock options granted to 12 new employees, totaling 50,500 shares. The options, with an exercise price of $15.48 per share, were issued as inducements for joining the company, in line with Nasdaq Listing Rule 5635(c)(4). Each option vests over four years, with 25% vesting after the first year. Additionally, options will be fully exercisable if employment is terminated under specific conditions within a year of a 'change in control.' This move supports Karyopharm's growth in developing innovative cancer therapies.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) announced that CEO Michael Kauffman will present at the 39th Annual J.P. Morgan Healthcare Conference on January 11, 2021, at 4:30 p.m. ET, followed by a Q&A session at 4:50 p.m. ET. The presentation will be available via live webcast, and a replay will be archived for 30 days. Karyopharm is focused on developing innovative cancer therapies, with its lead compound, XPOVIO® (selinexor), already approved for multiple hematologic malignancies in the U.S. and under review in Europe.
On January 3, 2021, Antengene Corporation announced the submission of a New Drug Application (NDA) for ATG-010 (selinexor, XPOVIO®) to the South Korean Ministry of Food and Drug Safety. The NDA, which includes Orphan Drug Designation, aims to treat relapsed/refractory multiple myeloma and diffuse large B-cell lymphoma. The application is supported by positive results from pivotal studies STORM and SADAL. Antengene also filed NDAs in Singapore and Australia and highlights the urgency for innovative therapies in hematological malignancies.