Welcome to our dedicated page for Karyopharm Therapeutics news (Ticker: KPTI), a resource for investors and traders seeking the latest updates and insights on Karyopharm Therapeutics stock.
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company focused on novel cancer therapies that target nuclear export dysregulation. Its lead product, XPOVIO (selinexor), is a first-in-class, oral exportin 1 (XPO1) inhibitor approved in the U.S. in multiple oncology indications and in various indications across more than 50 ex-U.S. territories and countries, according to company statements.
This news page aggregates company-issued updates and market disclosures related to Karyopharm. Readers can follow announcements on XPOVIO commercial performance, such as reported U.S. net product revenue and trends in license and royalty revenue from international partners, as described in the company’s earnings releases. The feed also covers progress in Karyopharm’s clinical pipeline, including multiple myeloma, endometrial cancer, myelofibrosis and diffuse large B-cell lymphoma (DLBCL).
Recent news has highlighted key milestones in late-stage development, including completion of enrollment in the Phase 3 SENTRY trial (XPORT-MF-034) in myelofibrosis and ongoing enrollment in the global Phase 3 XPORT-EC-042 trial in TP53 wild-type advanced or recurrent endometrial cancer. Company releases also describe Phase 2 data in heavily pretreated myelofibrosis patients and the design of additional studies such as SENTRY-2 and XPORT-MM-031 in multiple myeloma.
In addition to clinical and commercial updates, Karyopharm’s news includes financial results, preliminary revenue disclosures, strategic financing transactions involving term loans and convertible notes, and inducement equity awards granted under its inducement stock incentive plan. Investors and observers can use this page to review the company’s own descriptions of its operational progress, financing activities and anticipated clinical catalysts as reported in press releases and referenced in SEC filings.
Karyopharm Therapeutics (Nasdaq: KPTI), a commercial-stage pharmaceutical company focused on novel cancer therapies, has scheduled its fourth quarter and full year 2024 financial results announcement for Wednesday, February 19, 2025. The company will host a conference call and audio webcast at 8:00 a.m. ET on the same day.
Investors can access the conference call via phone at (800) 836-8184 (local) or (646) 357-8785 (international). The webcast and accompanying slides will be available in the Investor section of Karyopharm's website under 'Events & Presentations', with an archived version accessible approximately two hours after the event.
Karyopharm Therapeutics (Nasdaq: KPTI) has announced the granting of 28,000 restricted stock units (RSUs) to three newly-hired employees as of January 31, 2025. These RSU awards were granted under the Company's 2022 Inducement Stock Incentive Plan, in compliance with Nasdaq Listing Rule 5635(c)(4).
The RSUs will vest over three years, with 33 1/3% vesting on each anniversary of the grant date, contingent upon continued employment. In case of a change in control event, the RSUs will fully vest if the employee's employment is terminated for good reason or without cause within one year of such event.
Karyopharm Therapeutics (KPTI) announced preliminary unaudited 2024 results and 2025 objectives. The company expects total revenue of approximately $145 million and U.S. XPOVIO net product revenue of $113 million for full year 2024.
Key highlights include the Phase 3 SENTRY trial evaluating selinexor in myelofibrosis, with top-line results expected in H2 2025. The company updated the trial's co-primary endpoint to absolute mean change in total symptom score (Abs-TSS) and increased the sample size to 350 patients.
XPOVIO showed consistent demand in 2024 versus 2023, with growth in H2 2024 in both community and academic settings. The drug is now approved in over 45 countries. Cash position stands at approximately $109 million as of December 31, 2024, expected to fund operations into Q1 2026.
Karyopharm Therapeutics (NASDAQ: KPTI) has announced equity grants to four newly-hired employees as of December 31, 2024. The grants include 101,250 stock options with an exercise price of $0.6763 per share and 108,540 restricted stock units (RSUs).
The stock options vest over four years, with 25% vesting after one year and 1/48th monthly thereafter. The RSUs vest over three years, with 33 1/3% vesting annually. Both grants require continued employment with Karyopharm. In case of a change in control event followed by termination for good reason or without cause within one year, all grants will immediately vest in full.
Karyopharm Therapeutics (Nasdaq: KPTI) has appointed Lori Macomber as Executive Vice President, Chief Financial Officer and Treasurer, effective January 3, 2025. Macomber brings over 20 years of experience in life science companies' financial management, most recently serving as CFO at Legend Biotech
As part of her appointment, Macomber will receive inducement awards including a non-statutory stock option to purchase 650,000 shares and 160,000 restricted stock units (RSUs). The stock options will vest over four years, with 25% vesting after the first year and 1/48th monthly thereafter. The RSUs will vest over three years, with 33 1/3% vesting annually. Both awards include immediate vesting provisions in case of a change in control event followed by qualifying termination.
Karyopharm Therapeutics (Nasdaq: KPTI) has appointed Brendan Strong as Senior Vice President of Investor Relations and Corporate Communications. Strong joins from Argot Partners, where he served as Managing Director advising biopharmaceutical companies. His previous experience includes roles as investor relations lead at Tenet Healthcare, CFO of Tenet's Massachusetts Market, and equity research positions at Lehman Brothers and Barclays.
The company emphasizes Strong's experience will be valuable as they approach important milestones in 2025, particularly in advancing their late-stage pipeline and building on their multiple myeloma foundation. Strong holds an MBA from Harvard Business School and a B.S. in Finance from Rutgers University.
Karyopharm Therapeutics (Nasdaq: KPTI) announced it is in discussions with the FDA regarding the evolving treatment landscape in endometrial cancer and potential implications for their Phase 3 XPORT-EC-042 trial. Due to these ongoing discussions, the company will not address its endometrial cancer program at the Piper Sandler Healthcare Conference. An update will be provided after the FDA discussion concludes.
Karyopharm Therapeutics has announced the granting of 4,800 restricted stock units (RSUs) to two newly-hired employees as of November 30, 2024. The RSUs were granted under the company's 2022 Inducement Stock Incentive Plan, following Nasdaq Listing Rule 5635(c)(4). The RSUs will vest over three years, with 33 1/3% vesting annually. Full vesting is subject to continued employment, with immediate vesting possible in case of qualifying termination following a change in control event.
Karyopharm Therapeutics (Nasdaq: KPTI), a commercial-stage pharmaceutical company focused on novel cancer therapies, has announced its participation in the Piper Sandler 36th Annual Healthcare Conference. The company's senior management team will engage in a fireside chat on Tuesday, December 3 at 11:30 a.m. ET in New York.
The event will be accessible via live webcast in the Investor section of Karyopharm's website under 'Events & Presentations,' with replay availability after the event.
Karyopharm Therapeutics (Nasdaq: KPTI) has appointed Kristin Abate as Vice President, Chief Accounting Officer, and Assistant Treasurer, effective November 20, 2024. Abate, who has been serving as interim principal financial officer and interim principal accounting officer since November 6, 2024, will continue as interim principal financial officer. With over 15 years of finance experience, she joined Karyopharm in July 2019 and previously worked at PricewaterhouseCoopers LLP from 2007 to 2019. She holds a B.S. in Business Administration from Bryant University and a Masters of Science in Accountancy from Boston College.