Welcome to our dedicated page for Keros Therapeutics news (Ticker: KROS), a resource for investors and traders seeking the latest updates and insights on Keros Therapeutics stock.
Keros Therapeutics, Inc. develops clinical-stage protein therapeutics for disorders linked to dysfunctional signaling of the transforming growth factor-beta family of proteins. Company news centers on the rinvatercept (KER-065) program for neuromuscular diseases including Duchenne muscular dystrophy and amyotrophic lateral sclerosis, as well as elritercept for cytopenias in myelodysplastic syndrome and myelofibrosis.
Recurring updates include clinical data presentations, research collaborations, business highlights, financial results, and licensing economics tied to Takeda. Keros also reports governance changes, corporate presentations, portfolio prioritization, and capital actions such as its completed common-stock tender offer and capital return program.
Keros Therapeutics (Nasdaq: KROS) announced two abstracts from its KER-012 and KER-050 programs will be presented at the ASBMR 2022 Annual Meeting in Austin, Texas, from September 9-12, 2022. The oral presentation on KER-012 will discuss its tolerability and its potential bone anabolic effects, scheduled for September 11, 2022. Additionally, a poster presentation on KER-050 will cover its efficacy in improving bone loss in a mouse model of myelodysplastic syndrome, also on September 11, 2022.
Keros Therapeutics reported positive clinical data for KER-050 and KER-012, showcasing their potential in treating hematological disorders. In the Phase 2 study for KER-050, 44% of high transfusion burden patients achieved transfusion independence. KER-012 demonstrated favorable safety and biomarker improvements in healthy volunteers. Keros strengthened its cash position, extending its runway to Q3 2024. However, the company reported a net loss of $27.3 million for Q2 2022, up from $15.6 million in Q2 2021, attributed to increased R&D and infrastructure costs.
Keros Therapeutics, Inc. (Nasdaq: KROS) announced promising results from a preclinical study of RKER-012 for pulmonary arterial hypertension (PAH) at the Pulmonary Hypertension Association Conference (June 10-12, 2022). RKER-012, an Activin Receptor Type IIB ligand trap, significantly reduced cardiac and pulmonary pathology in a rodent model, leading to lower Fulton index and systolic pulmonary arterial pressure (sPAP) compared to the control. These results suggest RKER-012 could potentially mitigate PAH-related damage to the heart and lung tissues.
Keros Therapeutics (KROS) announced new data from its ongoing Phase 2 trial of KER-050, targeting myelodysplastic syndromes (MDS), presented at the EHA Congress. The trial showed 51.9% of evaluable patients achieved an overall erythroid response. Part 2 of the trial has begun with a starting dose of 3.75 mg/kg, allowing for escalation to 5.0 mg/kg. KER-050 displayed a favorable safety profile with no serious adverse events reported. Keros also shared preclinical findings on KER-050's potential effects on thrombopoiesis and anemia treatment, suggesting a strong basis for further development.
Keros Therapeutics, Inc. (Nasdaq: KROS) reported preliminary topline results from Part 1 of its Phase 1 clinical trial for KER-012, aimed at treating bone-related disorders. The trial involved 32 healthy postmenopausal subjects receiving varying doses of KER-012. Results indicate KER-012 was generally well tolerated up to the highest tested dose of 5 mg/kg, with no serious adverse events reported. Key findings include a 39.6% reduction in follicle-stimulating hormone after a single high dose and significant increases in bone formation markers. Part 2 is ongoing, with data expected in H2 2022.
Keros Therapeutics (Nasdaq: KROS) announced promising results from a preclinical study of RKER-012 for treating pulmonary arterial hypertension (PAH) at the ATS International Conference. RKER-012 effectively prevented increases in pulmonary arterial pressure and right ventricle hypertrophy in a rodent model. In a separate study, KER-012 did not increase red blood cell levels in cynomolgus monkeys. These findings suggest that KER-012 may offer a safer treatment option for PAH without dose-limiting side effects. The company emphasizes KER-012's potential in treating PAH without adversely affecting red blood cell counts.
Keros Therapeutics, Inc. (Nasdaq: KROS) announced the presentation of three abstracts from its KER-050 and ALK2 hematology programs at the 27th Annual Congress of the European Hematology Association (EHA) from June 9-17, 2022. The abstracts include a Phase 2 study on KER-050 for anemia treatment in myelodysplastic syndromes, along with two preclinical studies related to platelet production and anemia of inflammation. KER-050 aims to address low blood cell counts in patients suffering from significant hematological disorders.
Keros Therapeutics (Nasdaq: KROS) reported a net loss of $24.2 million for Q1 2022, up from $15.9 million in Q1 2021, primarily due to increased research and development and infrastructure costs. R&D expenses rose to $18.1 million compared to $11.5 million last year, while G&A expenses increased to $6.0 million from $4.3 million. The company has cash reserves of $228.6 million, expected to sustain operations through Q1 2024. Keros plans to share data from its Phase 2 trial of KER-050 in mid-2022 and initial results from the Phase 1 trial of KER-012 in Q2 2022.
Keros Therapeutics (KROS) reported its fourth quarter and full year 2021 financial results, highlighting a net loss of $6.9 million for Q4 and $58.7 million for the year, up from a $10.7 million loss in Q4 2020. Total revenue for 2021 was $20.1 million, attributed mainly to its strategic partnership with Hansoh for KER-050 in China, which brought in an $18 million upfront payment. Research and development expenses increased significantly to $18.8 million for Q4 as Keros advances clinical trials for KER-050 and KER-012. The company expects its cash reserves to last into Q1 2024.
Keros Therapeutics, Inc. (NASDAQ: KROS) announced that CEO Jasbir S. Seehra, Ph.D. will present at the 11th Annual SVB Leerink Global Healthcare Conference on February 18, 2022, at 9:20 am ET. The presentation will be available via live webcast and will be archived on Keros’ investors' page for 90 days post-event. Keros specializes in developing treatments for hematological and musculoskeletal disorders, focusing on unmet medical needs with candidates like KER-050 for cytopenias, KER-047 for iron imbalance-related anemia, and KER-012 for bone loss disorders.