Lilly Eli & Co Stock Price, News & Analysis

Eli Lilly (NYSE:LLY) announced positive Phase 3 ATTAIN-1 trial results for orforglipron, its investigational oral GLP-1 receptor agonist, in treating obesity. The once-daily pill demonstrated significant weight loss, with participants taking the highest dose (36mg) losing an average of 27.3 lbs (12.4%) compared to 2.2 lbs (0.9%) with placebo over 72 weeks.

The trial, involving 3,127 adults, met all primary and secondary endpoints. At the highest dose, 59.6% of participants lost ≥10% body weight, and 39.6% lost ≥15%. The drug also showed improvements in cardiovascular risk markers, including a 47.7% reduction in hsCRP levels. The safety profile aligned with injectable GLP-1 therapies, with mainly gastrointestinal side effects.

Lilly plans to submit orforglipron for regulatory review by year-end and is preparing for a global launch.

Eli Lilly (NYSE:LLY) announced groundbreaking results from SURPASS-CVOT, a landmark head-to-head Phase 3 cardiovascular outcomes trial comparing Mounjaro (tirzepatide) to Trulicity (dulaglutide) in type 2 diabetes patients with cardiovascular disease. The trial, involving over 13,000 participants across 30 countries, demonstrated Mounjaro's cardiovascular protection with an 8% lower rate of major adverse cardiovascular events compared to Trulicity.

Key findings include a 16% reduction in all-cause mortality, superior A1C and weight reductions, and enhanced kidney protection with Mounjaro. The drug showed a 28% reduction in MACE-3 events and 39% reduction in all-cause mortality compared to placebo in indirect comparison analyses. The safety profile remained consistent with previous studies, with 13.3% discontinuation rate due to adverse events.

Eli Lilly (NYSE:LLY) announced positive long-term results from the TRAILBLAZER-ALZ 2 extension study for Kisunla (donanemab-azbt) in early symptomatic Alzheimer's disease. The Phase 3 study demonstrated that the drug's benefits continued to grow over three years compared to an untreated control group.

Key findings include: cognitive decline reduction of -0.6 at 18 months and -1.2 at 36 months on the CDR-SB scale, 27% reduced risk of disease progression with earlier treatment, and over 75% of participants achieving amyloid clearance within 76 weeks. The study also confirmed Kisunla's established safety profile with no new safety signals observed over the three-year period.

Eli Lilly (NYSE:LLY) announced positive Phase 3 trial results for Jaypirca (pirtobrutinib) in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The BRUIN CLL-314 trial, comparing Jaypirca to Imbruvica (ibrutinib), met its primary endpoint of non-inferiority in overall response rate (ORR), with data favoring Jaypirca (p<0.05).

The groundbreaking study is the first head-to-head Phase 3 trial versus ibrutinib in CLL to include treatment-naïve patients, with this subgroup (n=225) showing particularly strong progression-free survival trends favoring pirtobrutinib. While progression-free survival (PFS) data is not yet mature, early trends favor Jaypirca with no detriment to overall survival.

These results will support future regulatory submissions alongside the upcoming BRUIN CLL-313 Phase 3 study results expected later in 2025.

Eli Lilly (NYSE:LLY) has successfully completed its acquisition of Verve Therapeutics (NASDAQ:VERV), a Boston-based clinical-stage biotechnology company specializing in genetic medicines for cardiovascular disease. The strategic acquisition aims to revolutionize cardiovascular treatment through the development of one-time genetic therapies that could provide lifelong cardiovascular risk reduction.

Led by Ruth Gimeno, Lilly's group vice president of Diabetes and Metabolic Research and Development, this acquisition represents a significant step towards expanding Lilly's presence in the cardiovascular therapeutic space and advancing innovative genetic medicine solutions.

Eli Lilly (NYSE:LLY) has received a positive opinion from the European Medicines Agency's CHMP for donanemab, its treatment for early symptomatic Alzheimer's disease. The recommendation specifically targets adults with confirmed amyloid pathology who are ApoE4 heterozygotes or non-carriers.

The positive opinion was supported by data from the TRAILBLAZER-ALZ 2 and TRAILBLAZER-ALZ 6 clinical trials. The trials demonstrated significant slowing of cognitive decline and reduced disease progression risk. The modified dosing schedule in TRAILBLAZER-ALZ 6 showed lower incidence of ARIA-E while maintaining efficacy.

With 6.9 million Europeans affected by Alzheimer's disease, and this number expected to double by 2050, the European Commission's final regulatory decision is anticipated in the coming months.

Eli Lilly (NYSE:LLY) has scheduled its second-quarter 2025 financial results announcement for August 7, 2025. The company will host a conference call at 8:30 a.m. Eastern time to discuss the quarterly performance with investors, media, and the general public.

The event will be accessible through a live webcast via Lilly's investor relations website, with a replay available after the call.

Eli Lilly (NYSE: LLY) has successfully completed its tender offer for Verve Therapeutics (NASDAQ: VERV). The offer, which expired on July 23, 2025, consisted of $10.50 per share in cash plus one non-tradable contingent value right (CVR) worth up to $3.00 per share upon achieving specific milestones.

The tender offer saw 49,882,464 shares validly tendered, representing approximately 55.7% of Verve's outstanding shares. All conditions of the offer have been met, and Lilly will promptly pay for all validly tendered shares. The acquisition is expected to be finalized on July 25, 2025.

Eli Lilly (NYSE:LLY) has received FDA approval for an updated label with a new dosing schedule for Kisunla (donanemab-azbt), its monthly Alzheimer's treatment. The modified titration schedule demonstrated a 41% reduction in ARIA-E incidents at 24 weeks and 35% reduction at 52 weeks compared to the original dosing.

The new dosing maintains Kisunla's efficacy while improving safety, achieving similar amyloid plaque removal (67% reduction vs. 69% originally) and P-tau217 reduction. The treatment, initially approved in July 2024, has shown to slow cognitive decline by up to 35% in less advanced patients and 22% in the overall population.