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Lilly's Foundayo (orforglipron), the only oral GLP-1 taken without food or water restrictions, was associated with significant weight loss in women at every stage of menopause

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Eli Lilly (NYSE: LLY) reported post-hoc results from ATTAIN-1 and ATTAIN-2 showing that women with obesity or overweight taking the highest dose of Foundayo (orforglipron), an oral GLP-1 taken without food or water restrictions, had significant weight loss at all menopause stages over 72 weeks.

Women lost up to 30.4 lbs (14.4%) in perimenopause and up to 28.2 lbs (14.1%) post-menopause in ATTAIN-1, and up to 27.8 lbs (13.6%) post-menopause in ATTAIN-2, with notable reductions in waist circumference and high proportions achieving ≥15% weight loss.

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AI-generated analysis. How Rhea-AI works. Not financial advice.

Positive

  • Up to 30.4 lbs (14.4%) weight loss in perimenopausal women in ATTAIN-1
  • Up to 28.2 lbs (14.1%) post-menopausal weight loss in ATTAIN-1 at 72 weeks
  • Up to 27.8 lbs (13.6%) post-menopausal weight loss in ATTAIN-2 with type 2 diabetes
  • Up to 51.5% of ATTAIN-1 participants achieved ≥15% weight loss
  • Up to 44.2% of ATTAIN-2 participants achieved ≥15% weight loss
  • Waist circumference reductions up to 4.9 in (12.5 cm) in ATTAIN-1

Negative

  • Results based on post-hoc subgroup analyses of ATTAIN-1 and ATTAIN-2
  • ATTAIN-2 pre-menopause subgroup had a small sample size (n=10)

News Market Reaction – LLY

+2.55%
1 alert
+2.55% News Effect
+$26.49B Valuation Impact
$1.07T Market Cap
6.05K Volume

On the day this news was published, LLY gained 2.55%, reflecting a moderate positive market reaction. This price movement added approximately $26.49B to the company's valuation, bringing the market cap to $1.07T at that time.

Data tracked by StockTitan Argus on the day of publication.

Market Context

This announcement highlights post-hoc ATTAIN-1 and ATTAIN-2 results showing that Foundayo 17.2 mg le...
Analysis

This announcement highlights post-hoc ATTAIN-1 and ATTAIN-2 results showing that Foundayo 17.2 mg led to up to 14.4% weight loss and notable waist reductions across all menopausal stages, including women with type 2 diabetes. It reinforces Lilly’s obesity strategy alongside Zepbound and follows recent moves in hematology, infectious diseases, and cardiometabolic editing. Investors may watch for longer-term safety, regulatory milestones, and payer coverage updates to gauge how these data translate into real-world adoption and revenue contribution.

Key Figures

Perimenopause weight loss ATTAIN-1: 30.4 lbs (14.4%) Post-menopause weight loss ATTAIN-1: 28.2 lbs (14.1%) Pre-menopause weight loss ATTAIN-1: 28.0 lbs (12.8%) +5 more
8 metrics
Perimenopause weight loss ATTAIN-1 30.4 lbs (14.4%) Women in perimenopause on highest Foundayo dose at 72 weeks
Post-menopause weight loss ATTAIN-1 28.2 lbs (14.1%) Women in post-menopause on highest Foundayo dose at 72 weeks
Pre-menopause weight loss ATTAIN-1 28.0 lbs (12.8%) Pre-menopausal women on highest Foundayo dose at 72 weeks
Participants in analyses more than 1,500 female participants ATTAIN-1 and ATTAIN-2 post-hoc analyses
≥15% weight loss ATTAIN-1 up to 51.5% of women Participants on highest Foundayo dose achieving ≥15% loss
≥15% weight loss ATTAIN-2 up to 44.2% of women Women with type 2 diabetes on highest Foundayo dose
Waist reduction ATTAIN-1 up to 4.9 in (12.5 cm) Change in waist circumference at 72 weeks
Waist reduction ATTAIN-2 up to 4.3 in (11.0 cm) Change in waist circumference at 72 weeks

Historical Context

5 past events · Latest: Jun 02 (Positive)
Pattern 5 events
Date Event Sentiment 24h Move Catalyst
Jun 02 Hematology portfolio update Positive -1.7% Highlighted expanding hematology portfolio and Phase 3 BRUIN CLL-322 data at EHA.
May 28 Access & coverage expansion Positive +4.0% Announced broad PBM coverage for Foundayo and Zepbound with low patient copays.
May 27 Conference participation Neutral +1.7% Disclosed participation and webcast plans for Goldman Sachs healthcare conference.
May 26 Infectious disease acquisitions Neutral -0.0% Announced three vaccine-focused acquisitions totaling several billion dollars in potential value.
May 25 Cardiometabolic trial data Positive -0.0% Reported strong VERVE-102 PCSK9 and LDL-C reductions with Fast Track designation.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

Recent positive clinical and portfolio news has sometimes seen muted or negative next-day moves, while access/coverage wins have aligned with stronger gains.

Recent Company History

Over the past few weeks, Lilly has reported several R&D and strategic updates. On May 25, positive Phase 1b data for VERVE-102 with up to 62% LDL-C reduction saw a near-flat reaction. A trio of infectious disease acquisitions announced on May 26 also produced little movement. In contrast, the May 28 announcement that Foundayo and Zepbound would be covered by major PBMs drove a 4.05% gain. The new Foundayo menopause data extends this obesity franchise narrative alongside ongoing hematology and cardiometabolic initiatives.

Key Terms

glp-1, type 2 diabetes, waist circumference, cardiometabolic risk, +1 more
5 terms
glp-1 medical
"the only oral GLP-1 taken without food or water restrictions"
GLP-1 (glucagon-like peptide-1) is a natural hormone in the body that helps regulate blood sugar levels and appetite. Its significance to investors lies in its role as the basis for a class of medications that address conditions like type 2 diabetes and obesity, which are large and growing markets. Advances or investments in GLP-1-based treatments can signal opportunities in healthcare innovation and potentially impact pharmaceutical companies’ growth.
type 2 diabetes medical
"women taking Foundayo lost significant weight across all stages of menopause, despite the additional challenge of living with type 2 diabetes"
Type 2 diabetes is a chronic condition where the body struggles to control blood sugar levels because it becomes less responsive to insulin, a hormone that helps regulate sugar in the blood. It matters to investors because it can lead to increased healthcare costs, affect workforce productivity, and influence the performance of companies in the healthcare and pharmaceutical sectors. Managing or preventing the condition has significant implications for public health and economic stability.
waist circumference medical
"women taking Foundayo saw meaningful reductions in their waist circumference, a measure associated with reduced abdominal fat"
Waist circumference is the measurement around the narrowest part of the torso or the midpoint between the ribs and hips, similar to noting a belt size. Investors care because it is a simple, widely used health marker linked to risks for conditions like diabetes and heart disease; changes in population or trial results can affect demand for drugs, devices, insurance and workplace health programs, and thus company prospects.
cardiometabolic risk medical
"a measure associated with reduced abdominal fat and cardiometabolic risk"
Cardiometabolic risk is the likelihood that a person will develop conditions such as heart disease, stroke or type 2 diabetes because of factors like high blood pressure, unhealthy cholesterol, excess body weight and poor blood sugar control. For investors, it matters because higher population risk drives demand for medical treatments, chronic-care services, insurance costs and workplace health programs—similar to how a rising number of warning lights signals growing strain on a machine and predictable market effects.
post-hoc analyses technical
"These findings, based on post-hoc analyses of more than 1,500 female participants in the ATTAIN-1 and ATTAIN-2 clinical trials"
Post-hoc analyses are additional examinations of data done after a study or trial has finished, rather than being planned beforehand. They are like looking back through a full photo album to spot patterns you didn’t decide to check before taking the pictures: useful for generating ideas but more prone to accidental findings and bias. Investors watch for whether results rely on post-hoc analyses because such findings are less reliable and may require confirmation before affecting a company’s value.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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In ATTAIN-1, women in perimenopause taking Foundayo lost up to 30.4 lbs (14.4%) and those in post-menopause lost up to 28.2 lbs (14.1%)

In ATTAIN-2, women taking Foundayo lost significant weight across all stages of menopause, despite the additional challenge of living with type 2 diabetes

Across studies, women taking Foundayo saw meaningful reductions in their waist circumference, a measure associated with reduced abdominal fat and cardiometabolic risk

INDIANAPOLIS, June 7, 2026 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY), the maker of Zepbound (tirzepatide), today announced results demonstrating that women with obesity or overweight who took the highest dose of Foundayo experienced significant weight loss at every stage of menopause. These findings, based on post-hoc analyses of more than 1,500 female participants in the ATTAIN-1 and ATTAIN-2 clinical trials, were presented at the American Diabetes Association (ADA) 86th Scientific Sessions.

Menopause is a major, yet often overlooked, driver of weight gain. Hormonal changes during this time can accelerate fat accumulation, particularly around the abdomen, and make weight loss harder to achieve and sustain.1 Despite affecting tens of millions of women in the U.S. alone, menopausal status has rarely been evaluated as a factor in obesity treatment efficacy.2

"Menopause can be an incredibly frustrating time for many women, partly because weight gain often feels beyond their control, and the biology of menopause can undermine even the most determined efforts to manage weight," said Rachel Batterham, OBE, MBBS, Ph.D., FRCP, Lilly senior vice president of medical innovation and external engagement. "These findings show that Foundayo was associated with meaningful weight loss in women at every stage of menopause. For women who have seen their weight become harder to manage precisely when their health is more at risk, this is what progress could look like."

Across ATTAIN‑1 and ATTAIN‑2, Foundayo was associated with significant reductions in body weight at 72 weeks across menopausal stages. In ATTAIN‑1, women who were pre‑, peri‑ and post‑menopausal lost up to 28.0 lbs (12.8%), 30.4 lbs (14.4%) and 28.2 lbs (14.1%) respectively on the highest dose of Foundayo. In ATTAIN‑2, women with type 2 diabetes who were pre‑, peri‑ and post‑menopausal lost up to 23.4 lbs (11.3%), 18.5 lbs (8.9%) and 27.8 lbs (13.6%) respectively. At the highest dose, up to 51.5% of women in ATTAIN-1 and up to 44.2% in ATTAIN-2 experienced ≥15% weight loss. Women also experienced meaningful reductions in waist circumference, with decreases of up to 4.9 inches (12.5 cm) in ATTAIN‑1 and up to 4.3 inches (11.0 cm) in ATTAIN‑2 at 72 weeks.

ATTAIN-1 and ATTAIN-2 Post-Hoc Analyses: Key Results with Foundayo 17.2 mg

ATTAIN-1


Pre-menopause

(n=171)

Perimenopause

(n=142)

Post-menopause

(n=152)

Baseline body weight

219.1 lbs (99.4 kg)

217.6 lbs (98.7 kg)

208.6 lbs (94.6 kg)

Change in body weight from baseline

-12.8%

 

(-28.0 lbs; -12.7 kg)

-14.4%

 

(-30.4 lbs; -13.8 kg)

-14.1%

 

(-28.2 lbs; -12.8 kg)

Percent of participants achieving ≥5% weight loss

80.3 %

80.9 %

82.7 %

Percent of participants achieving ≥10% weight loss 

61.5 %

64.2 %

64.1 %

Percent of participants achieving ≥15% weight loss

40.9 %

51.5 %

45.4 %

Percent of participants achieving ≥20% weight loss

24.2 %

29.9 %

23.8 %

Change in waist circumference from baseline

-4.5 in (-11.4 cm)

-4.9 in (-12.5 cm)

-4.8 in (-12.3 cm)

ATTAIN-2


Pre-menopause

(n=10)

Perimenopause

(n=33)

Post-menopause

(n=109)

Baseline body weight

237.9 lbs (107.9 kg)

209.7 lbs (95.1 kg)

202.2 lbs (91.7 kg)

Change in body weight from baseline

-11.3%

 

(-23.4 lbs; -10.6 kg)

-8.9%

 

(-18.5 lbs; -8.4 kg)

-13.6%

 

(-27.8 lbs; -12.6 kg)

Percent of participants achieving ≥5% weight loss

79.5 %

67.1 %

81.6 %

Percent of participants achieving ≥10% weight loss

52.5 %

39.5 %

68.0 %

Percent of participants achieving ≥15% weight loss

36.4 %

20.4 %

44.2 %

Percent of participants achieving ≥20% weight loss

32.1 %

9.7 %

21.7 %

Change in waist circumference from baseline

-4.3 in (-11.0 cm)

-3.3 in (-8.4 cm)

-4.3 in (-11.0 cm)

About Foundayo
Foundayo (orforglipron) is FDA-approved for adults with obesity, or some adults with overweight who also have weight-related medical problems to reduce excess body weight and maintain weight reduction long term, alongside a reduced-calorie diet and increased physical activity. Foundayo is a once-daily small molecule (non-peptide) oral glucagon-like peptide-1 receptor agonist that can be taken any time of the day without restrictions on food and water intake. Orforglipron was discovered by Chugai Pharmaceutical Co., Ltd. and licensed by Lilly in 2018. In addition to chronic weight management, orforglipron is being studied as a potential treatment for type 2 diabetes, obstructive sleep apnea, osteoarthritis knee pain, hypertension, peripheral artery disease and stress urinary incontinence.

About ATTAIN-1, ATTAIN-2 and ATTAIN clinical trial program 
ATTAIN-1 (NCT05869903) is a Phase 3, 72-week, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of Foundayo 5.5 mg, 9 mg and 17.2 mg as a monotherapy to placebo in adults with obesity, or overweight with at least one of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease, who did not have diabetes. The trial is the first Phase 3 study of this patient population in which treatment was evaluated as an adjunct to exercise and a balanced, healthy diet rather than a reduced-calorie diet. The trial randomized 3,127 participants across the U.S., Brazil, China, India, Japan, South Korea, Puerto Rico, Slovakia, Spain and Taiwan in 3:3:3:4 ratio to receive either 5.5 mg, 9 mg or 17.2 mg Foundayo or placebo. The primary objective of the study was to demonstrate that Foundayo (5.5 mg, 9 mg or 17.2 mg) is superior to placebo in body weight reduction from baseline after 72 weeks in people with a BMI ≥30.0 kg/m² or a BMI ≥27.0 kg/m² with at least one weight-related comorbidity and a history of at least one self-reported unsuccessful dietary effort to lose body weight.

ATTAIN-2 (NCT05872620) is a Phase 3, 72-week, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of Foundayo 5.5 mg, 9 mg or 17.2 mg as monotherapy with placebo in adults with obesity or overweight and type 2 diabetes. The trial randomized over 1,600 participants across the U.S., Argentina, Australia, Brazil, China, Czechia, Germany, Greece, India, South Korea and Puerto Rico in a 1:1:1:2 ratio to receive either 5.5 mg, 9 mg or 17.2 mg Foundayo or placebo. The primary objective of the study was to demonstrate that Foundayo (5.5 mg, 9 mg or 17.2 mg) is superior to placebo in mean body weight change from baseline at 72 weeks in people with a BMI ≥27.0 kg/m² and type 2 diabetes who are on stable treatment with either diet/exercise alone or up to three oral antihyperglycemic medications.

In both trials, all participants in the Foundayo treatment arms started the study at a dose of Foundayo 0.8 mg once-daily and then increased the dose in a step-wise approach at four-week intervals to their final randomized maintenance dose of 5.5 mg (via steps at 0.8 mg and 2.5 mg), 9 mg (via steps at 0.8 mg, 2.5 mg and 5.5 mg) or 17.2 mg (via steps at 0.8 mg, 2.5 mg, 5.5 mg, 9 mg and 14.5 mg). These trials were conducted using an investigational formulation of Foundayo at dosages equivalent to Foundayo tablets.

Endnotes and References

  1. Kapoor E, Collazo-Clavell ML, Faubion SS. Weight gain in women at midlife: a concise review. J Clin Endocrinol Metab. 2017;102(10):3732-3741.
  2. North American Menopause Society. The 2023 position statement of The North American Menopause Society. Menopause. 2023;30(4):573-590.

INDICATION AND SAFETY SUMMARY WITH WARNINGS
Foundayo (fown-DAY-oh) is a prescription medicine used with a reduced-calorie diet and increased physical activity to help adults with obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off.

  • Foundayo should not be used with other GLP-1 receptor agonist medicines.
  • It is not known if Foundayo is safe and effective for use in children.

Warnings – Foundayo may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

  • Do not use Foundayo if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).
  • Do not use Foundayo if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Do not use Foundayo if you have had a serious allergic reaction to orforglipron or any of the ingredients in Foundayo.

Foundayo may cause serious side effects, including:

Inflammation of the pancreas (pancreatitis). Stop taking Foundayo and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. Sometimes you may feel the pain from your abdomen to your back.

Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Foundayo. Tell your healthcare provider if you have stomach problems that are severe or will not go away.

Dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.

Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Foundayo with medicines that can cause low blood sugar, such as an insulin or sulfonylurea. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness, or feeling jittery.

Serious allergic reactions. Stop using Foundayo and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.

Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Foundayo.

Gallbladder problems. Gallbladder problems have happened in some people who use Foundayo. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Foundayo may increase the chance of food getting into your lungs during surgery or other procedures. Tell your healthcare providers that you are taking Foundayo before you are scheduled to have surgery or other procedures.

Common side effects
The most common side effects of Foundayo include nausea, constipation, diarrhea, vomiting, indigestion, stomach (abdominal) pain, headache, swollen belly, feeling tired, belching, heartburn, gas, and hair loss. These are not all the possible side effects of Foundayo. Talk to your healthcare provider about any side effect that bothers you or doesn't go away.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before taking Foundayo

  • Tell your healthcare provider about all the medicines you take. Foundayo may affect the way some medicines work, and some medicines may affect the way Foundayo works.
  • Pregnancy Exposure Registry: There will be a pregnancy exposure registry for women who have taken Foundayo during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you may contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979).
  • If you take birth control pills by mouth, talk to your healthcare provider before you take Foundayo. Birth control pills may not work as well while taking Foundayo. Your healthcare provider may recommend another type of birth control for 30 days after starting Foundayo and for 30 days after each dose increase of Foundayo.
  • Talk to your healthcare provider about low blood sugar and how to manage it. Tell your healthcare provider if you are taking medicines to treat diabetes including an insulin or sulfonylurea.

Review these questions with your healthcare provider:

❑ Do you have other medical conditions, including problems with your pancreas or kidneys, or severe problems with your liver, severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food?
❑ Do you have a history of diabetic retinopathy?
❑ Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)?
❑ Are you pregnant or plan to become pregnant? Foundayo may harm your unborn baby.
❑ Are you breastfeeding or plan to breastfeed? Breastfeeding is not recommended during treatment with Foundayo.
❑ Do you take any other prescriptions or over-the-counter medicines, vitamins, or herbal supplements?

How to take

  • Take Foundayo exactly as your healthcare provider tells you to.
  • Use Foundayo with a reduced-calorie diet and increased physical activity.
  • Take Foundayo by mouth 1 time each day, with or without food.
  • Swallow tablets whole. Do not break, crush, or chew the tablet.
  • If you miss a dose, take it as soon as possible. Do not take 2 doses of Foundayo in the same day.
  • Do not take more than 1 tablet per day.
  • If you miss taking Foundayo for 7 or more days in a row, call your healthcare provider to talk about how to restart your treatment.
  • If you take too much Foundayo, call your healthcare provider or Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

Learn more
Foundayo is a prescription medicine available in 0.8 mg, 2.5 mg, 5.5 mg, 9 mg, 14.5 mg, or 17.2 mg oral tablets. For more information, call 1-800-545-5979 or go to foundayo.lilly.com.

This summary provides basic information about Foundayo but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Foundayo and how to take it. Your doctor is the best person to help you decide if Foundayo is right for you.

OG CON BS APR2026

ZEPBOUND INDICATIONS AND SAFETY SUMMARY WITH WARNINGS

Zepbound (ZEHP-bownd) is an injectable prescription medicine used with a reduced-calorie diet and increased physical activity to help adults with:

  • obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off.
  • moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

Warnings - Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

  • Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).
  • Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound.

KwikPen: Do not share your KwikPen with other people, even if the pen needle has been changed. You may give other people a serious infection or get a serious infection from them.

Zepbound may cause serious side effects, including:

Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.

Dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.

Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.

Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. You may feel the pain from your abdomen to your back.

Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.

Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects

The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn't go away.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using Zepbound

  • Your healthcare provider should show you how to use Zepbound before you use it for the first time.
  • Talk to your healthcare provider about low blood sugar and how to manage it. Tell your healthcare provider if you are taking medicines to treat diabetes including an insulin or sulfonylurea.
  • If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.

Review these questions with your healthcare provider:

❑ Do you have other medical conditions, including problems with your pancreas, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food?
❑ Do you take diabetes medicines, such as insulin or sulfonylureas?
❑ Do you have a history of diabetic retinopathy?
❑ Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)?
❑ Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal supplements?
❑ Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound   may harm your unborn baby. Tell your healthcare provider if you become pregnant while using  Zepbound. Zepbound may pass into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.

  • Pregnancy Exposure Registry: There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you may contact Lilly at 1-800-LillyRx (1-800-545-5979).

How to take

  • Read the Instructions for Use that come with Zepbound.
  • Use Zepbound exactly as your healthcare provider says.
  • Use Zepbound with a reduced-calorie diet and increased physical activity.
  • Inject Zepbound under the skin (subcutaneously) of your stomach (abdomen), thigh, or have another person inject in the back of the upper arm. Do not inject ZEPBOUND into a muscle (intramuscularly) or vein (intravenously).
  • Use Zepbound 1 time each week, at any time of the day.
  • Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection.

If you take too much Zepbound, call your healthcare provider, call the Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

Zepbound is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg injection.

Learn more
Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979) or go to www.zepbound.lilly.com.

This summary provides basic information about Zepbound but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.

ZP CON BS 25FEB2026

About Lilly
Lilly is a medicine company turning science into healing to make life better for people around the world. We've been pioneering life-changing discoveries for 150 years, and today our medicines help tens of millions of people across the globe. Harnessing the power of biotechnology, chemistry and genetic medicine, our scientists are urgently advancing new discoveries to solve some of the world's most significant health challenges: redefining diabetes care; treating obesity and curtailing its most devastating long-term effects; advancing the fight against Alzheimer's disease; providing solutions to some of the most debilitating immune system disorders; and transforming the most difficult-to-treat cancers into manageable diseases. With each step toward a healthier world, we're motivated by one thing: making life better for millions more people. That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable. To learn more, visit Lilly.com and Lilly.com/news, or follow us on Facebook, Instagram, and LinkedIn. P-LLY

Cautionary Statement Regarding Forward-Looking Statements
This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about Foundayo (orforglipron) as a potential treatment for adults with obesity and the timeline for future readouts, presentations, and other milestones relating to Foundayo and its clinical trials, and reflects Lilly's current beliefs and expectations. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of drug research, development, and commercialization. Among other things, there is no guarantee that planned or ongoing studies will be completed as planned, that future study results will be consistent with study results to date, that Foundayo will receive additional regulatory approvals, or that Lilly will execute its strategy as expected. For further discussion of these and other risks and uncertainties that could cause actual results to differ from Lilly's expectations, see Lilly's Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission. Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the date of this release.

Trademarks and Trade Names
All trademarks or trade names referred to in this press release are the property of the company, or, to the extent trademarks or trade names belonging to other companies are referenced in this press release, the property of their respective owners. Solely for convenience, the trademarks and trade names in this press release are referred to without the ® and ™ symbols, but such references should not be construed as any indicator that the company or, to the extent applicable, their respective owners will not assert, to the fullest extent under applicable law, the company's or their rights thereto. We do not intend the use or display of other companies' trademarks and trade names to imply a relationship with, or endorsement or sponsorship of us by, any other companies.

Refer to:     

Niki Biro; niki_biro@lilly.com (Media)


Michael Czapar; czapar_michael_c@lilly.com (Investors)

Eli Lilly and Company logo. (PRNewsFoto, Eli Lilly and Company)

Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/lillys-foundayo-orforglipron-the-only-oral-glp-1-taken-without-food-or-water-restrictions-was-associated-with-significant-weight-loss-in-women-at-every-stage-of-menopause-302793332.html

SOURCE Eli Lilly and Company

FAQ

How much weight did women lose with Foundayo in the ATTAIN-1 trial?

In ATTAIN-1, women on the highest Foundayo dose lost up to 28.0 lbs pre-menopause, 30.4 lbs perimenopause, and 28.2 lbs post-menopause. According to Lilly, this corresponded to reductions of 12.8%, 14.4%, and 14.1% of baseline body weight over 72 weeks.

What were the ATTAIN-2 results for women with type 2 diabetes taking Foundayo (LLY)?

In ATTAIN-2, women with type 2 diabetes on the highest Foundayo dose lost up to 23.4 lbs pre-menopause, 18.5 lbs perimenopause, and 27.8 lbs post-menopause. According to Lilly, this equaled 11.3%, 8.9%, and 13.6% weight reductions from baseline at 72 weeks.

What percentage of women achieved at least 15% weight loss with Foundayo in ATTAIN-1 and ATTAIN-2?

A substantial proportion reached ≥15% weight loss on the highest dose. According to Lilly, up to 51.5% of women in ATTAIN-1 and up to 44.2% in ATTAIN-2 achieved at least 15% weight loss over the 72-week treatment period.

How did Foundayo affect waist circumference in the ATTAIN menopause analyses?

Foundayo was associated with notable waist circumference reductions across menopause stages. According to Lilly, decreases reached up to 4.9 inches (12.5 cm) in ATTAIN-1 and up to 4.3 inches (11.0 cm) in ATTAIN-2 after 72 weeks, suggesting reduced abdominal fat measures.

Why is Foundayo’s dosing without food or water restrictions important for Eli Lilly (LLY) investors?

Foundayo is described as an oral GLP-1 taken without food or water restrictions, which may support patient convenience and adherence. According to Lilly, these new weight loss data across menopause could enhance the asset’s profile within the competitive obesity and diabetes treatment markets.