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Lantheus Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update

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Lantheus (NASDAQ: LNTH) reported Q4 2025 worldwide revenue of $406.8 million and full year 2025 revenue of $1.54 billion. GAAP diluted EPS was $0.82 in Q4 and $3.41 for FY2025; adjusted diluted EPS were $1.67 and $6.08, respectively.

The company completed acquisitions, repurchased shares, divested its legacy SPECT business, and issued FY2026 guidance: $1.4–1.45 billion revenue and $5.00–5.25 adjusted EPS.

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Positive

  • FY2025 revenue of $1.54 billion
  • Adjusted EPS of $6.08 for FY2025
  • FY2026 guidance: $1.4–1.45B revenue and $5.00–5.25 adj EPS
  • Completed strategic acquisitions; paid $352.9M and $276.4M for acquisitions

Negative

  • Cash and equivalents fell to $359.1M from $912.8M year‑over‑year
  • Operating income decreased 32.2% in Q4 2025
  • PYLARIFY sales declined 9.7% year‑over‑year in Q4

Key Figures

Q4 2025 revenue: $406.8M FY 2025 revenue: $1.54B Q4 GAAP EPS: $0.82 +5 more
8 metrics
Q4 2025 revenue $406.8M Worldwide revenue, Q4 2025, up 4.0% year-over-year
FY 2025 revenue $1.54B Worldwide revenue for full year 2025
Q4 GAAP EPS $0.82 GAAP fully diluted EPS, Q4 2025
Q4 adjusted EPS $1.67 Adjusted fully diluted EPS, Q4 2025, up 4.7%
Q4 share repurchase $100M Common stock repurchased in Q4 2025 under existing plan
Cash & equivalents $359.1M Cash and cash equivalents at December 31, 2025
FY 2026 revenue guide $1.4B–$1.45B Full year 2026 revenue guidance issued Feb 26, 2026
FY 2026 adj EPS guide $5.00–$5.25 Full year 2026 adjusted fully diluted EPS guidance

Market Reality Check

Price: $75.72 Vol: Volume 1,213,695 vs 20-da...
high vol
$75.72 Last Close
Volume Volume 1,213,695 vs 20-day average 798,131 (relative volume 1.52x). high
Technical Price 75.72 is trading above 200-day MA at 65.02.

Peers on Argus

LNTH gained 2.87% while key peers were mixed: ALKS -4.49%, AMRX -0.68%, INDV +0....

LNTH gained 2.87% while key peers were mixed: ALKS -4.49%, AMRX -0.68%, INDV +0.96%, PBH +0.04%, HCM -0.03%, suggesting a stock-specific reaction to earnings.

Previous Earnings Reports

5 past events · Latest: Nov 06 (Negative)
Same Type Pattern 5 events
Date Event Sentiment Move Catalyst
Nov 06 Q3 2025 earnings Negative -6.2% Q3 2025 results, updated FY2025 guidance, acquisition integration and CEO retirement plan.
Aug 06 Q2 2025 earnings Negative -28.6% Q2 2025 revenue decline, lowered FY2025 guidance and PYLARIFY sales pressure.
May 07 Q1 2025 earnings Negative -23.2% Q1 2025 EPS declines, lowered guidance and mixed pipeline/clinical updates.
Nov 06 Q3 2024 earnings Positive -20.7% Strong Q3 2024 growth in PYLARIFY and DEFINITY with narrowed FY2024 guidance.
Jul 31 Q2 2024 earnings Positive -4.5% Q2 2024 double‑digit revenue growth and pipeline expansion transactions.
Pattern Detected

Recent earnings releases have often been followed by notable downside moves, with an average move of -16.64% across the last five earnings events.

Recent Company History

Over the past five earnings cycles (Jul 2024–Nov 2025), Lantheus reported recurring revenue growth but faced pressure from PYLARIFY deceleration and repeated guidance updates. The company executed acquisitions of Life Molecular Imaging and Evergreen Theragnostics, expanded its PET portfolio, and announced a SPECT divestiture and CEO transition. Prior earnings often coincided with negative share reactions, so this update continues a narrative of strategic repositioning around radiodiagnostics and pipeline-driven growth.

Historical Comparison

-16.6% avg move · In the last 5 earnings releases, LNTH’s average move was -16.64%, often skewed to the downside. Toda...
earnings
-16.6%
Average Historical Move earnings

In the last 5 earnings releases, LNTH’s average move was -16.64%, often skewed to the downside. Today’s +2.87% reaction to Q4/FY2025 results is modestly positive versus that history.

Across recent earnings, Lantheus has shifted from high PYLARIFY-driven growth toward a broader PET radiodiagnostic portfolio, integrating acquisitions, divesting SPECT, and repeatedly resetting guidance as it refocuses on late-stage assets.

Market Pulse Summary

This announcement highlights Q4 2025 revenue of $406.8M, adjusted EPS of $1.67, and full-year revenu...
Analysis

This announcement highlights Q4 2025 revenue of $406.8M, adjusted EPS of $1.67, and full-year revenue of $1.54B, alongside a sharpened focus on PET radiodiagnostics. Management outlines 2026 guidance of $1.4B–$1.45B revenue and $5.00–$5.25 adjusted EPS, with cash at $359.1M after acquisitions and buybacks. Investors may watch execution on up to four potential 2026 FDA decisions and the impact of divesting the legacy SPECT business.

Key Terms

gaap, non-gaap, free cash flow, pdufa, +3 more
7 terms
gaap financial
"GAAP fully diluted earnings per share of $0.82 and $3.41 for the fourth quarter"
GAAP, or Generally Accepted Accounting Principles, are a set of standardized rules and guidelines that companies follow when preparing their financial statements. They ensure consistency, transparency, and comparability across different companies, making it easier for investors to understand and compare financial information accurately. This helps investors make informed decisions based on trustworthy and uniform financial reports.
non-gaap financial
"Adjusted net income (non-GAAP) | | $110.7 | | $115.4 |"
Non-GAAP refers to financial measures that companies use to show their earnings or performance without including certain expenses or income that are often added back to give a different picture. It matters because it can make a company's results look better or more favorable, but it may also hide important costs, so investors need to look at both GAAP (official rules) and non-GAAP numbers to get a full understanding.
free cash flow financial
"Net cash provided by operating activities and free cash flow were $90.2 million and $81.4 million"
Free cash flow is the amount of money a company has left over after paying all its expenses and investing in its business, like buying equipment or updating facilities. It shows how much cash is available to reward shareholders, pay down debt, or save for future growth. This helps investors understand if a company is financially healthy and able to grow.
pdufa regulatory
"securing 2026 PDUFA dates for three radiodiagnostic assets:"
PDUFA, short for the Prescription Drug User Fee Act, is a law that allows drug companies to pay fees to the government to speed up the review process for new medicines. This helps bring important drugs to market more quickly, which can impact their availability and pricing. For investors, PDUFA timelines can influence the timing of a drug’s approval and potential market success.
hatch-waxman regulatory
"awaiting FDA approval and the resolution of Hatch-Waxman litigation for PNT2003"
Hatch‑Waxman is a U.S. law that creates a fast-track pathway for generic drug makers to prove a copy of an approved medicine is the same, while also letting original drug makers restore some patent life and win short-term exclusivity. Think of it as a legal balancing act that decides when cheaper copies can enter the market and when brand-name drugs keep protection—information that directly affects future sales, competition, and company valuations.
spect medical
"Completed the divestiture of the legacy SPECT business to SHINE Technologies LLC"
SPECT (Single Photon Emission Computed Tomography) is a medical imaging technique that uses a very small amount of radioactive material and a rotating camera to create three-dimensional pictures of how blood and tissues are functioning inside organs. For investors, SPECT matters because it is used to support clinical diagnoses, trial endpoints, device or drug approvals, and market demand for imaging equipment and tracers—similar to how a multi‑angle camera reveals a hidden object’s shape and condition.
nda regulatory
"On a forward-looking basis, the Company does not provide GAAP income per common share guidance or a reconciliation"
An NDA, or nondisclosure agreement, is a legal contract that keeps certain information private between parties. It’s like a promise not to share sensitive details, helping protect business ideas, strategies, or data from being leaked or used without permission. For investors, NDAs help ensure that confidential information remains secure, enabling trust and open communication during business discussions.

AI-generated analysis. Not financial advice.

  • Worldwide revenue of $406.8 million and $1.54 billion for the fourth quarter and full year 2025
  • GAAP fully diluted earnings per share of $0.82 and $3.41 for the fourth quarter and full year 2025
  • Adjusted fully diluted earnings per share of $1.67 and $6.08 for the fourth quarter and full year 2025
  • Repurchased $100 million of shares of common stock in the fourth quarter pursuant to the previously announced stock repurchase plan that was approved by the Board in July 2025
  • Company announced today that it is sharpening its strategic focus to innovative radiodiagnostics and pursuing value‑maximizing alternatives for radiotherapeutic assets to support long-term growth
  • Company provides full year 2026 revenue and adjusted fully diluted earnings per share guidance

BEDFORD, Mass., Feb. 26, 2026 (GLOBE NEWSWIRE) -- Lantheus Holdings, Inc. (Lantheus or the Company) (NASDAQ: LNTH), the leading radiopharmaceutical-focused company committed to enabling clinicians to Find, Fight and Follow disease to deliver better patient outcomes, today reported financial results for its fourth quarter and full year ended December 31, 2025.

“In 2025 we accomplished the important goal of maintaining market leadership with PYLARIFY. In addition, we expanded both our commercial portfolio of radiopharmaceuticals with Neuraceq as well as our pipeline through the acquisitions of Life Molecular Imaging and Evergreen Theragnostics,” said Mary Anne Heino, Chief Executive Officer of Lantheus. “In 2026, we are aligning our strategic focus on PET radiodiagnostics, with clear priorities around execution and investment. With up to four FDA approvals this year, we will ensure fit-for-purpose launch readiness for our new products, selectively advance late-stage pipeline assets and allocate capital thoughtfully to support sustainable growth and a compelling long-term outlook.”

Summary Financial Results

  Three Months Ended
December 31,
 
(in millions, except per share data - unaudited) 2025  2024  % Change 
Worldwide revenue $406.8  $391.1   4.0%
GAAP net income (loss) $54.1  $(11.8)  558.8%
GAAP fully diluted earnings (loss) per share $0.82  $(0.17)  578.8%
Adjusted net income (non-GAAP) $110.7  $115.4   (4.1%)
Adjusted fully diluted earnings per share (non-GAAP) $1.67  $1.59   4.7%
             

Fourth Quarter 2025

  • Worldwide revenue increased 4.0% to $406.8 million compared to the same period in 2024.
  • Sales of PYLARIFY were $240.2 million, a decrease of 9.7%.
  • Sales of DEFINITY were $85.3 million, a decrease of 1.0%.
  • Sales of Neuraceq were $31.0 million.
  • Operating income decreased 32.2% to $77.2 million. Adjusted operating income (non-GAAP) decreased 8.5% to $138.9 million.
  • Fully diluted earnings per share increased 578.8% to $0.82, compared to fully diluted loss per share of ($0.17) in the prior year period. Adjusted fully diluted earnings per share (non-GAAP) increased 4.7% to $1.67, compared to $1.59 in the prior year period.
  • Net cash provided by operating activities and free cash flow were $90.2 million and $81.4 million, respectively.

Balance Sheet

  • At December 31, 2025, the Company's cash and cash equivalents were $359.1 million, after payments of $276.4 million and $352.9 million for the acquisitions of Evergreen Theragnostics, Inc. (“Evergreen”) and Life Molecular Imaging, respectively, and payment of approximately $300 million for the repurchase of common stock, compared to $912.8 million at December 31, 2024.
  • The Company currently has access to up to $750.0 million from a revolving line of credit.

Recent Business Highlights

  • The Company announced today that it is sharpening its strategic focus to innovative radiodiagnostics and is prioritizing its investment in the development and commercialization of innovative PET radiodiagnostics, alongside a decision to pursue value‑maximizing alternatives for radiotherapeutic assets to support long‑term growth.
  • Completed the divestiture of the legacy SPECT business to SHINE Technologies LLC (effective January 1, 2026), a decisive action taken to focus on PET radiodiagnostics and simplify the Company’s operating model.
  • Demonstrated the strategic expansion of the Lantheus PET portfolio as Neuraceq exited 2025 as the second largest and fastest growing commercially approved amyloid PET imaging agent utilized in the U.S.
  • Advanced the late-stage pipeline to launch readiness, securing 2026 PDUFA dates for three radiodiagnostic assets: new PSMA PET formulation (March 6), OCTEVY (March 29), and MK-6240 (August 13); and awaiting FDA approval and the resolution of Hatch-Waxman litigation for PNT2003, a radioequivalent to Lutathera.

Full Year 2026 Financial Guidance

  Guidance Issued February 26, 2026 
FY 2026 Revenue $1.4 billion - $1.45 billion 
FY 2026 Adjusted fully diluted EPS $5.00 - $5.25 
    

On a forward-looking basis, the Company does not provide GAAP income per common share guidance or a reconciliation of GAAP income per common share to adjusted fully diluted EPS because the Company is unable to predict with reasonable certainty business development and acquisition related expenses, purchase accounting fair value adjustments, and any one-time, non-recurring charges. These items are uncertain, depend on various factors, and could be material to results computed in accordance with GAAP. As a result, it is the Company’s view that a quantitative reconciliation of adjusted fully diluted EPS on a forward-looking basis is not available without unreasonable effort.

Conference Call and Webcast

As previously announced, the Company will host a conference call and webcast on Thursday, February 26, 2026, at 8:00 a.m. ET. To access the conference call or webcast, participants should register online at https://investor.lantheus.com/news-events/calendar-of-events.

A replay will be available approximately two hours after completion of the webcast and will be archived on the same web page for at least 30 days.

The conference call will include a discussion of non-GAAP financial measures. Reference is made to the most directly comparable GAAP financial measures, the reconciliation of the differences between the two financial measures, and the other information included in this press release, our Form 8-K filed with the SEC today, or otherwise available in the Investor Relations section of our website located at www.lantheus.com.

The conference call may include forward-looking statements. See the cautionary information about forward-looking statements in the safe-harbor section of this press release.

About Lantheus

Lantheus is the leading radiopharmaceutical-focused company, delivering life-changing science to enable clinicians to Find, Fight and Follow disease to deliver better patient outcomes. Headquartered in Massachusetts with offices in New Jersey, Canada, Germany, Switzerland, Sweden and the United Kingdom, Lantheus has been providing radiopharmaceutical solutions for nearly 70 years. For more information, visit www.lantheus.com.

Internet Posting of Information

The Company routinely posts information that may be important to investors in the “Investors” section of its website at www.lantheus.com. The Company encourages investors and potential investors to consult its website regularly for important information about the Company.

Non-GAAP Financial Measures

The Company uses non-GAAP financial measures, such as adjusted net income and its line components; adjusted fully diluted net income per share; adjusted operating income, and free cash flow. The Company’s management believes that the presentation of these measures provides useful information to investors. These measures may assist investors in evaluating the Company’s operations, period over period. However, these measures may exclude items that may be highly variable, difficult to predict and of a size that could have a substantial impact on the Company’s reported results of operations for a particular period. Management uses these and other non-GAAP measures internally for evaluation of the performance of the business, including the evaluation of results relative to employee performance compensation targets. Investors should consider these non-GAAP measures only as a supplement to, not as a substitute for or as superior to, measures of financial performance prepared in accordance with GAAP.

Safe Harbor for Forward-Looking and Cautionary Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, that are subject to risks and uncertainties and are made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These forward-looking statements may be identified by their use of terms such as “advance,” “believe,” “continue,” “could,” “driving,” “expect,” “guidance,” “maintain,” “may,” “on track,” “plan,” “potential,” “predict,” “progress,” “should,” “target,” “will,” “would” and other similar terms. Such forward-looking statements include our guidance for the fiscal year 2026 and our plans to successfully execute on the commercialization of marketed products, ensure launch readiness for new products, advance a focused late-stage pipeline, and allocate capital thoughtfully, and are based upon current plans, estimates and expectations that are subject to risks and uncertainties that could cause actual results to materially differ from those described in the forward-looking statements. The inclusion of forward-looking statements should not be regarded as a representation that such plans, estimates and expectations will be achieved. Readers are cautioned not to place undue reliance on the forward-looking statements contained herein, which speak only as of the date hereof. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by law. Risks and uncertainties that could cause our actual results to materially differ from those described in the forward-looking statements include: (i) continued market expansion, penetration and reimbursement for our established commercial products, particularly PYLARIFY, DEFINITY and Neuraceq, in a competitive environment, and our ability to clinically and commercially differentiate our products;(ii) our ability to obtain U.S. Food and Drug Administration (“FDA”) approval for our new formulation of our F-18 prostate-specific membrane antigen (“PSMA”) positron emission tomography (“PET”) imaging agent, to complete the technology transfer across our PET manufacturing facilities (“PMF”) network for such new formulation, to obtain FDA approval for each PET manufacturing facility to manufacture the new formulation, to obtain adequate coding, coverage and payment, including transitional pass-through payment status (“TPT Status”), for such new formulation and to have customers adopt such new formulation; (iii) the availability of raw materials, key components, equipment, manufacturing timeslots, either used in the production of our products and product candidates, or by customers of our products and product candidates, including, but not limited to PET scanners for PYLARIFY, Neuraceq, MK-6240, LNTH-2501 and NAV-4694; (iv) our ability to have third parties manufacture our products and product candidates and our ability to manufacture DEFINITY in our in-house manufacturing facility, in amounts and at the times needed; (iv) (v) our ability to satisfy our obligations under our existing clinical development partnerships using Neuraceq, MK-6240 or NAV-4694 as a research tool and under the license agreements through which we have rights to those assets, and to further develop and commercialize MK-6240 and NAV-4694 as approved products; (vi) our ability to continue to successfully integrate acquisitions, including of Life Molecular Imaging Limited (“Life Molecular”) and Evergreen Theragnostics, Inc. (“Evergreen”), which could be impacted by unforeseen expenses related to integration activities, the accuracy of our financial models, the potential for unforeseen liabilities within those businesses, the ability to integrate disparate information technology systems, retain key talent and create a merged corporate culture that successfully realizes the full potential of the combined organization; (vii) our ability to obtain FDA approval for LNTH-2501, our investigational kit for the preparation of Gallium-68 edotreotide injection, which has been studied for use in conjunction with a PET scan to stage and localize neuroendocrine tumors in adult and pediatric patients, and approval for PNT2003, and to be successful in the patent litigation associated with PNT2003; (viii) the cost, efforts and timing for clinical development, manufacturing, regulatory approval, adequate coding, coverage and payment, and successful commercialization of our product candidates and new clinical applications and territories for our products, in each case, that we or our strategic partners may undertake, including those investigational assets for which FDA approval is anticipated this year;(ix) our ability to identify opportunities to collaborate with strategic partners and to acquire or in-license additional diagnostic and therapeutic product opportunities in oncology, neurology and other strategic areas and continue to grow and advance our pipeline of products;(x) the effect that changes to management, including the recent turnover in our leadership and senior management team, could have on our business; and (xi) the risk and uncertainties discussed in our filings with the Securities and Exchange Commission (including those described in the Risk Factors section in our Annual Reports on Form 10-K and our Quarterly Reports on Form 10-Q).

- Tables Follow -

Lantheus Holdings, Inc.

Consolidated Statements of Operations

(in thousands, except per share data – unaudited)
       
  Three Months Ended
December 31,
  Twelve Months Ended
December 31,
 
  2025  2024  2025  2024 
Revenues $406,786  $391,110  $1,541,609  $1,533,910 
Cost of goods sold  165,911   142,565   599,657   545,619 
Gross profit  240,875   248,545   941,952   988,291 
Operating expenses            
Sales and marketing  46,319   43,640   178,691   177,940 
General and administrative  69,892   57,869   275,121   193,689 
Research and development  47,480   35,325   177,308   168,098 
Total operating expenses  163,691   136,834   631,120   539,727 
Gain on sale of assets     2,161      8,415 
Operating income  77,184   113,872   310,832   456,979 
Interest expense  5,078   5,045   19,749   19,669 
Investment in equity securities - unrealized loss  9,488   119,056   8,617   43,564 
Other income  (7,747)  (9,446)  (31,326)  (37,231)
Income (loss) before income taxes  70,365   (783)  313,792   430,977 
Income tax expense  16,277   11,007   80,233   118,535 
Net income (loss) $54,088  $(11,790) $233,559  $312,442 
Net income (loss) per common share:            
Basic $0.82  $(0.17) $3.46  $4.52 
Diluted $0.82  $(0.17) $3.41  $4.36 
Weighted average common shares outstanding:            
Basic  65,582   69,217   67,489   69,199 
Diluted  66,315   69,217   68,443   71,651 
             


Lantheus Holdings, Inc.

Consolidated Revenues Analysis

(in thousands, except percent data – unaudited)
       
  Three Months Ended  Twelve Months Ended 
  December 31,  December 31, 
  2025  2024  Change $  Change %  2025  2024  Change $  Change % 
PYLARIFY $240,204  $265,953  $(25,749)  (9.7)% $989,116  $1,057,834  $(68,718)  (6.5)%
Other radiopharmaceutical oncology  -      -   -%  -   384   (384)  (100.0)%
Total radiopharmaceutical oncology  240,204   265,953   (25,749)  (9.7)%  989,116   1,058,218   (69,102)  (6.5)%
DEFINITY  85,313   86,163   (850)  (1.0)%  330,248   317,792   12,456   3.9%
Neuraceq  31,005      31,005   100.0%  51,447      51,447   100.0%
TechneLite  20,983   25,107   (4,124)  (16.4)%  86,803   95,487   (8,684)  (9.1)%
Other precision diagnostics  5,944   6,192   (248)  (4.0)%  24,616   24,231   385   1.6%
Total precision diagnostics  143,245   117,462   25,783   22.0%  493,114   437,510   55,604   12.7%
Strategic partnerships and other revenue  23,337   7,695   15,642   203.3%  59,379   38,182   21,197   55.5%
Total revenues $406,786  $391,110  $15,676   4.0% $1,541,609  $1,533,910  $7,699   0.5%
                         


Lantheus Holdings, Inc.

Reconciliation of GAAP to Non-GAAP Financial Measures

(in thousands, except per share and percent data – unaudited)
       
  Three Months Ended
December 31,
  Twelve Months Ended
December 31,
 
  2025  2024  2025  2024 
Net income (loss) $54,088  $(11,790) $233,559  $312,442 
Stock and incentive plan compensation  17,543   22,164   85,563   76,393 
Amortization of acquired intangible assets  16,485   11,846   47,111   43,807 
Campus consolidation costs  16   35   (130)  72 
Contingent consideration fair value adjustments  397   (1,294)  1,379   (2,699)
Non-recurring fees     6,723   2,633   6,723 
Gain on sale of assets     (2,161)     (8,415)
Strategic collaboration and license costs  5,539   (8)  21,812   66,213 
Investment in equity securities - unrealized loss(a)  9,511   119,056   8,726   43,564 
Acquisition, integration and divestiture-related costs  21,703   207   84,348   1,553 
Other  (5,000)  447   (8,024)  2,720 
Income tax effect of non-GAAP adjustments(b)  (9,613)  (29,794)  (60,503)  (57,701)
Adjusted net income $110,669  $115,431  $416,474  $484,672 
Adjusted net income, as a percentage of revenues  27.2%  29.5%  27.0%  31.6%
             


  Three Months Ended
December 31,
  Twelve Months Ended
December 31,
 
  2025  2024  2025  2024 
Net income (loss) per share - diluted $0.82  $(0.17) $3.41  $4.36 
Stock and incentive plan compensation  0.26   0.31   1.25   1.07 
Amortization of acquired intangible assets  0.25   0.16   0.69   0.61 
Campus consolidation costs  0.00   0.00   (0.00)  0.00 
Contingent consideration fair value adjustments  0.01   (0.02)  0.02   (0.04)
Non-recurring fees     0.09   0.04   0.09 
Gain on sale of assets     (0.03)     (0.12)
Strategic collaboration and license costs  0.08   (0.00)  0.32   0.92 
Investment in equity securities - unrealized loss(a)  0.14   1.65   0.13   0.61 
Acquisition, integration and divestiture-related costs  0.33   0.00   1.23   0.02 
Other  (0.08)  0.01   (0.12)  0.04 
Income tax effect of non-GAAP adjustments(b)  (0.14)  (0.41)  (0.88)  (0.80)
Adjusted net income per share - diluted(c) $1.67  $1.59  $6.08  $6.76 
Weighted-average common shares outstanding - diluted  66,315   72,451   68,443   71,651 
             

(a) Non-GAAP amount excludes a gain of $23 and $109 from the change in value of other assets for the three and twelve months ended December 31, 2025, respectively.

(b) Represents the estimated income tax effect of the adjustments between GAAP net income (loss) and non-GAAP adjusted net income.

(c) Amounts may not add due to rounding.

Lantheus Holdings, Inc.

Reconciliation of GAAP to Non-GAAP Financial Measures (Continued)

(in thousands, except per share and percent data – unaudited)
 
       
  Three Months Ended
December 31,
  Twelve Months Ended
December 31,
 
  2025  2024  2025  2024 
Operating income $77,184  $113,872  $310,832  $456,979 
Stock and incentive plan compensation  17,543   22,164   85,563   76,393 
Amortization of acquired intangible assets  16,485   11,846   47,111   43,807 
Campus consolidation costs  16   35   (130)  72 
Contingent consideration fair value adjustments  397   (1,294)  1,379   (2,699)
Non-recurring fees     6,723   2,633   6,723 
Gain on sale of assets     (2,161)     (8,415)
Strategic collaboration and license costs  5,539   (8)  21,812   66,213 
Acquisition, integration and divestiture-related costs  21,703   207   84,348   1,553 
Other     447   1,703   2,720 
Adjusted operating income $138,867  $151,831  $555,251  $643,346 
Adjusted operating income, as a percentage of revenues  34.1%  38.8%  36.0%  41.9%
             


Lantheus Holdings, Inc.

Reconciliation of Free Cash Flow

(in thousands – unaudited)
       
  Three Months Ended
December 31,
  Twelve Months Ended
December 31,
 
  2025  2024  2025  2024 
Net cash provided by operating activities $90,178  $157,730  $390,141  $544,750 
Capital expenditures  (8,788)  (16,369)  (36,089)  (51,625)
Free cash flow $81,390  $141,361  $354,052  $493,125 
             
Net cash used in investing activities $(11,510) $(6,602) $(627,168) $(226,015)
Net cash used in financing activities $(100,786) $(103,659) $(316,584) $(118,536)
             


Lantheus Holdings, Inc.

Condensed Consolidated Balance Sheets

(in thousands – unaudited)
 
  December 31,  December 31, 
  2025  2024 
Assets      
Current assets:      
Cash and cash equivalents $359,121  $912,814 
Accounts receivable, net  358,640   321,258 
Inventory, net  64,674   68,025 
Income tax receivable  15,387   8,177 
Other current assets  21,400   16,359 
Assets held for sale  80,742    
Total current assets  899,964   1,326,633 
Investment in equity securities  42,213   39,489 
Property, plant and equipment, net  163,686   176,798 
Intangibles, net  722,779   161,761 
Goodwill  239,517   61,189 
Deferred tax assets, net  109,196   170,233 
Other long-term assets  50,044   44,237 
Total assets $2,227,399  $1,980,340 
Liabilities and Stockholders’ Equity      
Current liabilities:      
Current portion of long-term debt and other borrowings $738  $974 
Accounts payable  42,906   34,560 
Accrued expenses and other current liabilities  267,307   204,992 
Liabilities held for sale  22,468    
Total current liabilities  333,419   240,526 
Asset retirement obligations  138   23,344 
Long-term debt and other borrowings, net of current portion  568,678   565,279 
Long-term deferred tax liabilities  54,246    
Long-term contingent consideration liabilities  73,255    
Other long-term liabilities  107,866   63,180 
Total liabilities  1,137,602   892,329 
Total stockholders’ equity  1,089,797   1,088,011 
Total liabilities and stockholders’ equity $2,227,399  $1,980,340 
       


Contacts:
Mark Kinarney
Vice President, Investor Relations
978-671-8842
ir@lantheus.com

Melissa Downs
Executive Director, External Communications
646-975-2533
media@lantheus.com


FAQ

What were Lantheus (LNTH) Q4 2025 revenue and EPS results?

Lantheus reported Q4 2025 worldwide revenue of $406.8 million and GAAP diluted EPS of $0.82. According to Lantheus, adjusted diluted EPS for Q4 2025 were $1.67, reflecting non‑GAAP adjustments and operational results.

What FY2026 financial guidance did Lantheus (LNTH) issue on Feb 26, 2026?

Lantheus provided FY2026 guidance of $1.4–1.45 billion revenue and $5.00–5.25 adjusted diluted EPS. According to Lantheus, GAAP EPS was not provided due to uncertainty around acquisition and one‑time items.

How did Lantheus (LNTH) change its strategic focus in February 2026?

Lantheus said it is sharpening focus on PET radiodiagnostics and pursuing value‑maximizing alternatives for radiotherapeutics. According to Lantheus, the company divested its legacy SPECT business effective January 1, 2026, to simplify operations.

What material capital actions did Lantheus (LNTH) report in Q4 2025?

Lantheus repurchased $100 million of common stock in Q4 and paid approximately $300 million total for repurchases in 2025. According to Lantheus, acquisition payments totaled $352.9M and $276.4M for two strategic purchases.

Which pipeline and regulatory milestones did Lantheus (LNTH) disclose for 2026?

Lantheus disclosed three PDUFA dates in 2026: a PSMA PET formulation (March 6), OCTEVY (March 29), and MK‑6240 (August 13). According to Lantheus, PNT2003 is awaiting FDA action and Hatch‑Waxman litigation resolution.
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