Contextlogic Inc. Stock Price, News & Analysis

LogicBio Therapeutics (Nasdaq:LOGC) announced the first patient has been dosed with LB-001, a gene editing therapy for methylmalonic acidemia (MMA) in the SUNRISE Phase 1/2 clinical trial. Conducted at Monroe Carell Jr. Children's Hospital at Vanderbilt, this marks a key step in addressing MMA, a rare genetic disorder affecting 1 in 50,000 newborns. The trial aims to evaluate LB-001's safety and tolerability in pediatric patients aged 3-12, with future enrollment for infants as young as 6 months. LogicBio expects to announce interim clinical data by the end of 2021.

LogicBio Therapeutics, Inc. (Nasdaq:LOGC) announced on June 1, 2021, that CEO Frederic Chereau will participate in virtual fireside chats at two investor conferences. The events include the Jefferies Virtual Healthcare Conference on June 4 at 9:30 AM ET and the JMP Securities Life Sciences Conference on June 16 at 2:00 PM ET. Interested parties can access live webcasts through the Investors section of the company's website. LogicBio focuses on pioneering gene delivery and editing platforms to address rare diseases, utilizing innovative technologies like GeneRide™ and sAAVy™.

LogicBio Therapeutics (Nasdaq: LOGC) announced the promotion of Dr. Daniel Gruskin to Chief Medical Officer and the appointment of Dr. Stephen Boyer as Vice President of Regulatory and Quality Affairs, along with Dr. Peter Pechan as Vice President of Gene Therapy. These leadership changes support ongoing advancements in the Phase I/II SUNRISE clinical trial of LB-001, an investigational treatment for methylmalonic acidemia (MMA). The new appointments come amidst recent collaborations with Daiichi Sankyo and CANbridge Pharmaceuticals.

LogicBio Therapeutics (Nasdaq: LOGC) reported its first-quarter financial results for 2021, showing a net loss of $10.3 million or $0.32 per share, compared to a loss of $9.5 million or $0.41 per share in Q1 2020. R&D expenses decreased to $6.4 million from $7.2 million, while G&A expenses rose to $4.1 million. The company had cash reserves of $63.9 million and expects this to sustain operations for at least the next 12 months. Anticipated milestones include patient enrollment in the SUNRISE trial for LB-001 by mid-2021 and interim data by year-end.

LogicBio Therapeutics (Nasdaq: LOGC) announced key appointments on May 10, 2021, with Andrea Paul as general counsel and corporate secretary, effective May 17, and Janice Olson as senior vice president of strategy and portfolio management, effective June 7. Both bring extensive experience in pharmaceutical and biotechnology sectors. The company also reported the resignation of COO Kyle Chiang effective May 28. CEO Frederic Chereau expressed optimism about the new appointments and their potential to enhance LogicBio's gene delivery and gene editing platforms amid ongoing collaborations with Daiichi Sankyo and CANbridge Pharmaceuticals.

LogicBio Therapeutics (Nasdaq:LOGC) announced preclinical data presentations at the upcoming 24th Annual ASGCT Virtual Meeting from May 11-14, 2021. Key findings include the oral presentation by Dr. Jing Liao on the sL65 AAV capsid, which demonstrated high potency in humanized mice and non-human primates for liver disease treatment. Additionally, data on the GeneRide platform showed improved outcomes for methylmalonic acidemia and significantly reduced bilirubin levels in Crigler-Najjar syndrome in mouse models. These presentations highlight the potential of LogicBio's genetic therapies.

LogicBio Therapeutics (Nasdaq:LOGC) announced results from a retrospective study on severe methylmalonic acidemia (MMA), a rare genetic disorder. Conducted at the ACMG Annual Clinical Genetics Meeting, the study included 18 pediatric patients, demonstrating a significant post-liver transplantation decrease in methylmalonic acid levels, indicating improved metabolic stability. However, no substantial differences were observed in emergency room visits or hospitalizations before and after transplantation. The findings will inform the clinical trial design for LB-001, a program targeting MMA.

LogicBio Therapeutics (LOGC) announced a strategic collaboration with CANbridge Pharmaceuticals to develop gene therapies for rare diseases in Greater China. Under the agreement, CANbridge obtains an option for an exclusive license for LB-001, targeting methylmalonic acidemia (MMA). LogicBio will receive an upfront payment of $10 million and is eligible for up to $581 million in milestone payments, along with double-digit royalties. This partnership aims to expand patient access to innovative therapies in the underserved Chinese market.

LogicBio Therapeutics (Nasdaq: LOGC) announced a research collaboration with Daiichi Sankyo on April 27, 2021. The partnership focuses on developing treatments for two undisclosed indications using LogicBio's GeneRide™ gene insertion platform. This agreement allows Daiichi Sankyo to negotiate worldwide licenses for the programs. Previously, LogicBio cleared an Investigational New Drug application for a treatment targeting pediatric methylmalonic acidemia and initiated the Phase 1/2 SUNRISE trial. The GeneRide platform aims to provide durable therapeutic protein expression while minimizing risks associated with other gene editing methods.