Leap Therapeutic Stock Price, News & Analysis

Leap Therapeutics, Inc. (NASDAQ: LPTX) announced its presentation of long-term follow-up data from Part A of the DisTinGuish study at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, scheduled for June 2-6, 2023, in Chicago, IL. This Phase 2 clinical trial evaluates the efficacy of DKN-01, an anti-DICKKOPF-1 antibody, in combination with tislelizumab and chemotherapy for patients with advanced gastroesophageal adenocarcinoma (GEA). The presentation will occur on June 5, 2023, at 11:30 a.m. ET, featuring Samuel J. Klempner from Harvard Medical School. The study aims to assess the safety and effectiveness of DKN-01 in various patient groups, as Leap continues to develop targeted cancer therapies.

Leap Therapeutics, Inc. (Nasdaq: LPTX) has completed enrollment in Part A of the Phase 2 DeFianCe study, which evaluates DKN-01, its anti-Dickkopf-1 antibody, in combination with bevacizumab and chemotherapy for advanced colorectal cancer (CRC).

This milestone is considered critical for the DKN-01 program, reflecting strong interest from investigators and patients. The study enrolled 33 patients in Part A and is set to expand into Part B with a total of 130 patients. The primary goal is to assess progression-free survival, with secondary objectives including overall response rate and overall survival.

DKN-01 is designed to disrupt the immune suppressive tumor microenvironment associated with CRC, offering potential therapeutic benefits. Initial data from the study is expected in mid-2023.

Leap Therapeutics, Inc. (Nasdaq:LPTX) reported its financial results for Q4 and the year ending December 31, 2022. The net loss grew to $54.6 million, up from $40.6 million in 2021, driven by increased research and development and administrative expenses. The acquisition of Flame Biosciences added $50 million in cash and expanded Leap's pipeline with clinical and preclinical antibody programs. Leap initiated clinical trials for DKN-01 in gastroesophageal and colorectal cancers and promoted Jason Baum to Chief Scientific Officer. Comprehensive financial metrics include $45 million in R&D expenses for 2022, a significant rise from $32.2 million in 2021.

Leap Therapeutics, Inc. (NASDAQ:LPTX) announced the expiration of BeiGene's option under their Exclusive Option and License Agreement for DKN-01, its anti-DKK1 monoclonal antibody, in certain Asian territories. Despite this, both companies will continue their collaboration on the DisTinGuish trial, which studies DKN-01 in combination with BeiGene's tislelizumab and chemotherapy for first-line gastric cancer. The trial aims for 160 patient enrollment completion by late 2023. Leap's cash runway extends to mid-2025, facilitating further clinical studies and the development of its Claudin18.2 programs for GI cancers.

Leap Therapeutics has acquired Flame Biosciences, adding FL-301, an anti-Claudin18.2 monoclonal antibody, to its pipeline. This merger enhances Leap's drug portfolio and includes two preclinical programs and approximately $50 million in cash as of December 31, 2022. The combined company will have a cash balance of about $115 million, sufficient to fund operations through mid-2025. Leap plans to advance its DKN-01 program while expanding its focus on developing novel, biomarker-targeted therapies for cancer patients. The merger will require approval from Leap's stockholders, who will own 58% of the combined company post-transaction.

Leap Therapeutics, Inc. (Nasdaq: LPTX) will present at B. Riley Securities' 3rd Annual Oncology Conference on January 18, 2022, at 1:30 p.m. Eastern Time. The presentation will be made by Douglas E. Onsi, President and CEO, Cynthia Sirard, MD, Chief Medical Officer, and Jason Baum, PhD, VP of Translational Medicine. Attendees can access the live webcast on the company's Investors page, with a replay available afterwards. Leap Therapeutics focuses on targeted and immuno-oncology therapies, with its leading candidate, DKN-01, in trials for various cancers.