Welcome to our dedicated page for Leap Therapeutic news (Ticker: LPTX), a resource for investors and traders seeking the latest updates and insights on Leap Therapeutic stock.
The news feed for Leap Therapeutics, Inc. (historically Nasdaq: LPTX) captures the company’s transition from a biotechnology issuer focused on targeted and immuno-oncology therapeutics to the renamed Cypherpunk Technologies Inc. with an added digital asset treasury strategy. Press releases describe how the public company changed its name to Cypherpunk Technologies Inc., plans to trade under the ticker CYPH, and intends to acquire and hold Zcash (ZEC) while continuing cancer drug development through a subsidiary that will take the Leap Therapeutics name.
News items cover clinical and preclinical updates for the oncology pipeline, including detailed results from the randomized Phase 2 DeFianCe study of sirexatamab (DKN-01) plus bevacizumab and chemotherapy in microsatellite stable colorectal cancer, and preclinical findings for FL-501, a GDF-15–targeting monoclonal antibody associated with cancer cachexia research. Releases describe statistically significant benefits in DKK1-high colorectal cancer subgroups and activity of FL-501 in animal models of cachexia and chemotherapy-induced weight loss.
Investors can also follow strategic and corporate developments such as the initiation of a process to explore strategic alternatives for sirexatamab and FL-501, workforce reductions and restructuring to conserve cash, and the closing of a private placement led by Winklevoss Capital to fund the digital asset treasury strategy. Additional news highlights governance changes, including new board appointments linked to the financing, and the company’s rationale for focusing on Zcash as a privacy-preserving digital asset.
This page brings together these oncology, digital asset, financing, and governance announcements so readers can review how the historical LPTX issuer evolved into Cypherpunk Technologies Inc. and how its cancer programs and Zcash-focused treasury strategy are described in official communications.
Leap Therapeutics (Nasdaq:LPTX) announced a corporate overview presentation at the H.C. Wainwright BioConnect 2021 Conference from January 11-14, 2021. Douglas E. Onsi, the company’s President and CEO, will present on January 11 at 6:00 a.m. Eastern Time. The presentation can be accessed on the company’s Investors page, with a replay available for a limited time. Leap is known for its immuno-oncology therapeutics, including the clinical candidate DKN-01, targeting various cancers.
Leap Therapeutics (Nasdaq:LPTX) announced that President and CEO Douglas E. Onsi will present a corporate overview at the 39th Annual J.P. Morgan Healthcare Conference on January 14, 2021, at 3:40 p.m. ET. The presentation will be available via webcast on the company's Investors page. Leap focuses on developing targeted and immuno-oncology therapeutics, with its lead candidate, DKN-01, currently in clinical trials for various cancers. The company has a strategic partnership with BeiGene for DKN-01's development in Asia, excluding Japan.
Leap Therapeutics (Nasdaq:LPTX) announced the publication of preclinical results regarding DKN-01 in Molecular Cancer Research. DKN-01, a monoclonal antibody blocking the DKK1 protein, showed positive effects in mouse cancer models including tumor growth inhibition. The studies indicated that DKN-01 can activate NK cells and reduce metastases, suggesting its potential effectiveness in combination with PD-1 inhibitors. Leap has also initiated trials combining DKN-01 with BeiGene's tislelizumab for patients with high DKK1 levels in gastroesophageal cancers.
Leap Therapeutics, Inc. (Nasdaq:LPTX) announced that CEO Douglas E. Onsi will participate in a fireside chat at the Piper Sandler 32nd Annual Virtual Healthcare Conference from December 1-3, 2020. A pre-recording of the chat is accessible on the company’s investors page, with a replay available for 90 days. Leap focuses on developing targeted and immuno-oncology therapeutics, with DKN-01 as their lead candidate, currently in clinical trials for various cancers. The company collaborates with BeiGene for DKN-01's development in Asia, Australia, and New Zealand.
Leap Therapeutics, Inc. (Nasdaq:LPTX) reported its Q3 2020 financial results, showing a net loss of $7.1 million, down from $7.9 million in Q3 2019. Key highlights include the first patient dosed in a Phase 2a study of DKN-01 in combination with BeiGene's tislelizumab for metastatic gastric cancer. The FDA granted Fast Track designation to DKN-01 for high DKK1 expression G/GEJ cancer. The company ended the quarter with $58 million in cash and marketable securities, highlighting effective cost management with R&D expenses at $5.4 million, down from $5.8 million year-over-year.
Leap Therapeutics (Nasdaq:LPTX) announced that its President and CEO, Douglas E. Onsi, will present a corporate overview at the Stifel 2020 Virtual Healthcare Conference from November 16-18, 2020. The presentation is scheduled for November 16 at 9:20 a.m. ET and will be available via live webcast on the company's Investors page. Leap is focused on developing targeted and immuno-oncology therapeutics, with its lead candidate, DKN-01, currently in clinical trials for various cancers. Further details on Leap can be found on their official website.
Leap Therapeutics (Nasdaq:LPTX) presented clinical data from its Phase 2 trial of DKN-01 for recurrent epithelial endometrial cancers at the AACR Virtual Conference on November 9-10, 2020. DKN-01, a monoclonal antibody targeting Dickkopf-1 (DKK1), showed efficacy in biomarker-selected patients, particularly those with Wnt signaling alterations. Key findings included a 10% overall response rate and improved outcomes in patients with Wnt activating mutations and high DKK1 expression. The study suggests DKN-01 offers a promising treatment option with a favorable safety profile.
Leap Therapeutics (Nasdaq: LPTX) announced promising results from a Phase 1b/2a clinical trial of DKN-01 for advanced esophagogastric cancer presented at the SITC 2020 Annual Meeting. The study revealed that patients with high tumoral DKK1 expression had superior clinical outcomes, including doubled median progression-free survival (PFS) and better overall survival (OS) rates, as compared to those with low DKK1 levels. These findings suggest that DKK1 expression could serve as a predictive biomarker, supporting further studies combining DKN-01 with anti-PD-1 therapies.
Leap Therapeutics, a biotechnology company, will present crucial data on its DKN-01 monoclonal antibody for esophagogastric cancer at the Society of Immunotherapy of Cancer's (SITC) 35th Annual Meeting, from November 9-14, 2020. Dr. Samuel J. Klempner will present findings that show DKK1 expression correlates with improved clinical outcomes in patients. DKN-01, recognized by the FDA with Orphan Drug and Fast Track designations, targets the Dickkopf-1 protein, crucial in tumor biology and immunosuppression.
Leap Therapeutics (Nasdaq:LPTX) announced that the FDA has granted Fast Track designation to its drug DKN-01 for treating gastric and gastroesophageal junction adenocarcinoma in patients whose tumors express high Dickkopf-1 (DKK1) protein after prior chemotherapy. This designation aims to expedite the drug's development and review, enabling faster access for patients with unmet medical needs. DKN-01 is also undergoing trials for various cancers and has received Orphan Drug Designation for gastric and gastroesophageal junction cancers.