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Lyell Immunopharma reports developments tied to its next-generation chimeric antigen receptor, or CAR T-cell, therapy pipeline for patients with cancer. The company’s recurring updates center on ronde-cel, an autologous dual-targeting CD19/CD20 CAR T-cell product candidate for large B-cell lymphoma, and LYL273, a GCC-targeted CAR T-cell product candidate for metastatic colorectal cancer and other GCC-expressing cancers.
Company news also covers clinical-trial activity, FDA designation updates, manufacturing capabilities at the LyFE Manufacturing Center, quarterly financial results, equity financing activity, licensing transactions, investor-conference participation and executive or governance changes.
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Lyell Immunopharma, Inc. (Nasdaq: LYEL) reported financial results for Q4 and full year 2022, highlighting a net loss of $8.4 million for Q4 and $183.1 million for the year, but significantly increased revenue of $48.4 million for Q4 and $84.7 million for the year, up from $2.8 million and $10.7 million in 2021. The company's cash position stands at $710.3 million as of December 31, 2022, supporting ongoing clinical trials and a robust pipeline. Lyell initiated Phase 1 trials for two product candidates targeting solid tumors and presented promising nonclinical data at several conferences. The company expects initial clinical data from LYL797 and LYL845 in 2024.
Lyell Immunopharma will present at the 41st Annual J.P. Morgan Healthcare Conference on January 10 at 4:30 pm PT. The presentation will showcase Lyell's pipeline, including CAR T cell product candidates LYL797 and LYL845, both in Phase 1 trials, and the innovative LYL119 targeting ROR1. Key technologies will be highlighted, such as NR4A3 gene knockout and Stim-RTM for enhanced CAR T cell activity. A live webcast will be available on the company’s website with a 30-day replay.