Keenova Presents New TERLIVAZ® (terlipressin) Data Analyses at Kidney Week 2026

Keenova Therapeutics (MNK) will present two TERLIVAZ analyses at the American Society of Nephrology Kidney Week, taking place October 21–25, 2026.

Rhea-AI Summary

Keenova Therapeutics (MNK) will present two TERLIVAZ analyses at the American Society of Nephrology Kidney Week, taking place October 21–25, 2026. The presentations examine hepatorenal syndrome–acute kidney injury (HRS-AKI), a rapid decline in kidney function in adults with advanced liver disease.

An October 22 poster will cover a retrospective study of real-world terlipressin use and outcomes in U.S. adults hospitalized with HRS-AKI. An October 24 oral presentation will cover an exploratory subgroup analysis of the CONFIRM trial examining terlipressin and renal replacement therapy in patients with HRS-AKI who are ineligible for liver transplantation. TERLIVAZ is FDA-approved to improve kidney function in adults with hepatorenal syndrome with rapid reduction in kidney function.

Key Terms

hepatorenal syndrome-acute kidney injury, retrospective cohort study, renal replacement therapy, acute-on-chronic liver failure, +1 more

5 terms

hepatorenal syndrome-acute kidney injury medical

"hepatorenal syndrome-acute kidney injury (HRS-AKI)"

A severe complication in people with advanced liver disease where the kidneys suddenly stop working because blood flow and body chemistry are altered by the failing liver. Think of the liver as a central pump that keeps pipes and filters supplied; when it fails, the kidneys (filters) can shut down even though they are not directly damaged. For investors, it matters because the condition drives urgent medical care, creates demand for specific drugs and devices, and is a common endpoint in clinical trials and regulatory decisions for liver- and kidney-related therapies.

retrospective cohort study technical

"A Retrospective Cohort Study Evaluating Real-World Use and Outcomes"

A retrospective cohort study is a research approach that looks back at existing records to compare outcomes for groups of people who were exposed to something (a drug, treatment, or risk factor) and those who were not. Think of it like reviewing past school report cards to see whether students who used a particular study method tended to do better; investors use these studies to judge the strength of evidence about safety or effectiveness, which can influence regulatory expectations, market confidence, and valuation risks.

renal replacement therapy medical

"Terlipressin and Renal Replacement Therapy in Patients with HRS-AKI"

Renal replacement therapy is medical treatment that takes over the job of failing kidneys by removing waste and excess fluid from the blood, most commonly through dialysis or by restoring kidney function with a transplant. Investors care because these therapies drive demand for machines, supplies, drugs and ongoing care services, creating predictable revenue streams, regulatory and reimbursement risks, and sensitive cost pressures—think of it as a lifeline device market that must be paid for continuously.

acute-on-chronic liver failure medical

"acute-on-chronic liver failure (ACLF) Grade 3"

A sudden, severe worsening of an existing long-term liver disease that leads to rapid loss of liver function and often triggers failure of other organs; think of a chronic problem that suddenly collapses into a medical emergency. Investors care because it drives urgent hospital treatments, accelerates demand for drugs, devices and transplants, raises short-term healthcare costs and regulatory urgency for therapies, and can materially affect companies developing liver-related diagnostics or treatments.

pulse oximetry medical

"Monitor patients for hypoxia using continuous pulse oximetry"

Pulse oximetry is a noninvasive way to estimate how much oxygen is in a person’s blood using a small sensor—commonly clipped to a finger, toe, or earlobe—that also reads pulse rate. For investors, it matters because this measurement is a common feature in medical and consumer health devices; its accuracy, regulatory status, and demand influence product adoption, sales, and the perceived reliability of companies that make or use the technology.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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DUBLIN, Oct. 21, 2026 /PRNewswire/ -- Keenova Therapeutics plc announced today that two presentations on hepatorenal syndrome-acute kidney injury (HRS-AKI) and TERLIVAZ^® (terlipressin) will be shared at the American Society of Nephrology (ASN) Kidney Week 2026, taking place October 21-25, 2026.

"These presentations add to the growing body of evidence supporting the use of TERLIVAZ in HRS-AKI," said Dr. Marek Honczarenko, Executive Vice President and Chief Scientific Officer at Keenova. "By examining treatment outcomes in both clinical trial and real-world settings, these analyses provide valuable insights that can help inform treatment decisions and patient care."

TERLIVAZ is the first and only FDA‑approved therapy indicated to improve kidney function in adults with HRS‑AKI.

Presentation Details

• A Retrospective Cohort Study Evaluating Real-World Use and Outcomes of Terlipressin in U.S. Adults Hospitalized with Hepatorenal Syndrome-Acute Kidney Injury
  • Authors: A. Sidney Barritt IV, MD, MSCR; Kavish R. Patidar, DO; Robert J. Wong, MD, MS; Xingyue Huang, PhD; Mary Panaccio, PhD; Jonathan Lilley, BA; Nisha Wadhwani; Rahul Rajkumar, MD, MPH; Christopher White, MD, MSPH
  • Poster Session: October 22
  • Poster Board #: TH-PO0769
      
• Terlipressin and Renal Replacement Therapy in Patients with HRS-AKI Ineligible for Liver Transplant: An Exploratory Subgroup Analysis of the CONFIRM Trial
  • Authors: Kevin Regner, MD, MS; Nancy Reau, MD; Kavish Patidar, MD; Laurie Larson, MSN, APRN; HoChong Gilles, DNP, APRN; Nneka N. Ufere, MD, MSCE; Anooj Shah, PharmD, MBA; Richard Wu, PhD; Christopher White, MD, MSPH; R. Todd Frederick, MD
  • Oral Abstract Session: October 24
  • Abstract Publication #: SA-OR014

About Hepatorenal Syndrome-Acute Kidney Injury
Hepatorenal syndrome–acute kidney injury (HRS-AKI) is a life-threatening condition in adults with advanced liver disease that is marked by a rapid decline in kidney function¹ and is associated with high morbidity and mortality.² It is an acute medical emergency that requires hospitalization.³ A U.S. study based on national data revealed that the estimated annual number of inpatients diagnosed with HRS between 2018 and 2023 increased from 42,930 to 63,381.⁴

INDICATION
TERLIVAZ is indicated to improve kidney function in adults with hepatorenal syndrome with rapid reduction in kidney function.

LIMITATION OF USE

• Patients with a serum creatinine >5 mg/dL are unlikely to experience benefit.

IMPORTANT SAFETY INFORMATION

WARNING: SERIOUS OR FATAL RESPIRATORY FAILURE

• TERLIVAZ may cause serious or fatal respiratory failure. Patients with volume overload or with acute-on-chronic liver failure (ACLF) Grade 3 are at increased risk. Assess oxygenation saturation (e.g., SpO₂) before initiating TERLIVAZ. 
    
• Do not initiate TERLIVAZ in patients experiencing hypoxia (e.g., SpO₂ <90%) until oxygenation levels improve. Monitor patients for hypoxia using continuous pulse oximetry during treatment and discontinue TERLIVAZ if SpO₂ decreases below 90%.

Contraindications
TERLIVAZ is contraindicated:

• In patients experiencing hypoxia or worsening respiratory symptoms.
• In patients with ongoing coronary, peripheral, or mesenteric ischemia.

Warnings and Precautions

• Serious or Fatal Respiratory Failure: Obtain baseline oxygen saturation and do not initiate TERLIVAZ in hypoxic patients. Monitor patients for changes in respiratory status using continuous pulse oximetry and regular clinical assessments. Discontinue TERLIVAZ in patients experiencing hypoxia or increased respiratory symptoms.
    
  Manage intravascular volume overload by reducing or discontinuing the administration of albumin and/or other fluids and through judicious use of diuretics. Temporarily interrupt, reduce, or discontinue TERLIVAZ treatment until patient volume status improves. Avoid use in patients with ACLF Grade 3 because they are at significant risk for respiratory failure.
     
• Ineligibility for Liver Transplant: TERLIVAZ-related adverse reactions (respiratory failure, ischemia) may make a patient ineligible for liver transplantation, if listed. For patients with high prioritization for liver transplantation (e.g., MELD ≥35), the benefits of TERLIVAZ may not outweigh its risks.
     
• Ischemic Events: TERLIVAZ may cause cardiac, cerebrovascular, peripheral, or mesenteric ischemia. Avoid use of TERLIVAZ in patients with a history of severe cardiovascular conditions or cerebrovascular or ischemic disease. Discontinue TERLIVAZ in patients who experience signs or symptoms suggestive of ischemic adverse reactions.
     
• Embryo-Fetal Toxicity: TERLIVAZ may cause fetal harm when administered to a pregnant woman. If TERLIVAZ is used during pregnancy, the patient should be informed of the potential risk to the fetus.

Adverse Reactions

• The most common adverse reactions (≥10%) include abdominal pain, nausea, respiratory failure, diarrhea, and dyspnea.

Please click here to see full Prescribing Information, including BOXED WARNING.

About Keenova
Keenova Therapeutics is a leading U.S.-focused branded therapeutics company that strives to help patients with rare or unaddressed conditions live happier and healthier lives.

Keenova's rare disease capabilities underpin our diversified brands portfolio, which is focused across a wide range of specialty therapeutic areas of significant unmet need. These include rheumatology, ophthalmology, nephrology, neurology, pulmonology, orthopedics, urology, and neonatal respiratory critical care.

Headquartered in Dublin, Ireland, Keenova benefits from a strong U.S. manufacturing footprint with facilities in Louisiana, New Jersey, New York, Pennsylvania, and Wisconsin. To learn more, please visit www.keenova.com.

Keenova uses its website as a channel of distribution of important company information, such as press releases, investor presentations, and other financial information. It also uses its website to expedite public access to time-critical information regarding the Company in advance of or in lieu of distributing a press release or a filing with the U.S. Securities and Exchange Commission ("SEC") disclosing the same information. Therefore, investors should look to the Investor Relations page of the website for important and time-critical information. Visitors to the website can also register to receive automatic e-mail and other notifications alerting them when new information is made available on the Investor Relations page of the website.

Information Regarding Forward-Looking Statements
This release contains forward-looking statements, including with regard to TERLIVAZ^®, the efficacy, safety, potential treatments or indications, therapeutic outcomes or treatment responses of this product, and any statements that refer to expected, estimated or anticipated future results or that do not relate solely to historical facts. The statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those in the forward-looking statements: satisfaction of, and compliance with, regulatory and other requirements; actions of regulatory bodies and other governmental authorities; changes in laws and regulations; changes in market demand; issues with product quality, manufacturing or supply, or patient safety issues or adverse side effects or adverse reactions associated with TERLIVAZ; and other risks identified and described in more detail in the "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" sections of Keenova's most recent Annual Report on Form 10-K, and other filings and furnishings with the Securities and Exchange Commission (SEC), all of which are available on the SEC's website (www.SEC.gov) and Keenova's website (www.keenova.com). The forward-looking statements made herein speak only as of the date hereof and Keenova does not assume any obligation to update or revise any forward-looking statement, whether as a result of new information, future events and developments or otherwise, except as required by law.

References

1. Wong RJ, Balasubramanian J, Panaccio M, Huang X. Acute kidney injury and hepatorenal syndrome among hospitalized patients with chronic liver disease. JAMA Netw Open. 2025;8(5):e2511816.
2. Loftus M, Brown RS Jr, El-Farra NS, Owen EJ, Reau N, Wadei HM, Bernstein D. Improving the management of hepatorenal syndrome–acute kidney injury using an updated guidance and a new treatment paradigm. Gastroenterol Hepatol (N Y). 2023;19(9):527-536.
3. National Organization for Rare Disorders. Hepatorenal syndrome. Available at https://rarediseases.org/rare-diseases/hepatorenal-syndrome. Accessed March 17, 2026.
4. Goyes M, et al. Increasing incidence, cost, and mortality of AKI and HRS in hospitalized patients with cirrhosis. JAMA Netw Open. 2025;8(5):e2511822.

Contacts
Media:	Investors:
media.relations@keenova.com	investor.relations@keenova.com

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SOURCE Keenova Therapeutics