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Molecular Partners AG (MOLN) is a clinical-stage biotech company whose news flow is closely tied to the progress of its DARPin-based oncology pipeline. The company regularly issues updates on its clinical trials, preclinical data presentations and strategic collaborations, giving investors and observers insight into how its programs are advancing through development.
News about Molecular Partners often highlights milestones for its Radio-DARPin platform, including MP0712, a 212Pb-based candidate targeting DLL3 in small cell lung cancer and other neuroendocrine cancers, and MP0726, which targets mesothelin in cancers with high unmet need. Press releases describe regulatory steps such as Investigational New Drug applications, initiation of Phase 1/2a studies, and early human imaging data from compassionate care programs, as well as the role of its collaboration with Orano Med in radiotherapeutics.
Another major source of updates is the companys multispecific T cell engager MP0533, in Phase 1/2a for relapsed/refractory acute myeloid leukemia and myelodysplastic syndrome/AML. Molecular Partners reports interim clinical data, dosing refinements and response patterns, particularly in patients with lower disease burden, through conference presentations and ad hoc announcements. News items also cover MP0317, a tumor-localized CD40 agonist in an investigator-initiated Phase 2 trial in cholangiocarcinoma, and preclinical Switch-DARPin programs that use logic-gated immune activation.
Corporate communications further include quarterly and half-year financial results, cash runway commentary, and management changes such as the appointment of a Chief Scientific Officer. For readers following MOLN stock, this news page provides a centralized view of regulatory disclosures, scientific conference presentations and pipeline progress updates related to Molecular Partners DARPin therapeutics.
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Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) announced significant advancements in its Radio DARPin Therapy (RDT) platform, showcasing new preclinical data that highlights the technology's potential for targeted radionuclide delivery. The findings, which will be presented at the American Association for Cancer Research Annual Meeting on April 18, 2023, demonstrate reduced kidney accumulation and high tumor penetration of DARPins due to specific engineering. This innovative approach addresses historical safety concerns associated with small protein-based delivery vectors. The company aims to expand the use of RDT to a broader range of tumor targets, leveraging collaborations with major pharmaceutical firms such as Novartis.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) held its Annual General Meeting where shareholders approved all Board of Directors' motions. Key approvals included the financial statements for 2022 and the carry-forward of earnings totaling CHF 124 million, reducing prior losses from CHF 216 million to CHF 92 million. The Board received discharge for 2022, and all members were re-elected for another year. KPMG AG Zurich was confirmed as statutory auditors for 2023. The meeting also endorsed compensation motions for the Board and Management.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) has announced its Annual General Meeting scheduled for April 4, 2023, at 14:00 CET in Schlieren, Switzerland. The meeting will provide insights into the company's developments and future directions. Key financial dates include the Interim Management Statement for Q1 2023 on May 11 and the Half-year results on August 24. The company focuses on developing DARPin therapeutics, custom-built proteins aimed at addressing unmet medical needs, particularly in oncology and infectious diseases, with partnerships established with major pharmaceutical firms.
Molecular Partners AG (SIX: MOLN, NASDAQ: MOLN) reported significant advancements in its 2022 corporate highlights and financial results. The company initiated a Phase 1 study for MP0533, a tri-specific T-cell engager targeting acute myeloid leukemia, and presented promising preclinical data at the ASH Annual Meeting. Financially, Molecular Partners achieved CHF 189.6 million in total revenues, a substantial increase from CHF 9.8 million in 2021, resulting in a net profit of CHF 117.8 million. The company maintains a strong cash position of CHF 249.1 million, expected to fund operations into 2026. 2023 guidance indicates operating expenses of CHF 70-80 million.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN), a clinical-stage biotech firm specializing in DARPin therapeutics, will release its 2022 financial results on March 9, 2023, followed by an investor call on March 10, 2023. The call will summarize key highlights from Q4 and the full year. CEO Patrick Amstutz is scheduled to present at the 43rd Annual Cowen Health Care Conference on March 8, 2023, in Boston, MA. Investors can access a live webcast of the results presentation on the company’s website, with a replay available for 90 days thereafter.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) announced new preclinical data from its Radio DARPin Therapy Platform at the 12th International Symposium on Targeted Alpha Therapy (TAT 12) held on February 28, 2023, in Cape Town, South Africa.
The platform aims to enhance the delivery of radioactive payloads to tumors while minimizing kidney accumulation. Initial data indicate a significant reduction in kidney retention, allowing for higher doses of radioactivity at the tumor site without compromising therapeutic efficacy.
The company is advancing several in-house and partnered DARPin-based programs, addressing high unmet medical needs in oncology.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN), a biotech company focused on DARPin therapeutics, announced that its CEO, Patrick Amstutz, Ph.D., will be speaking at the SVB Leerink Global Healthcare Conference on February 15, 2023, at 12:00 pm ET. The presentation will provide insights into the company's clinical-stage advancements and partnerships within oncology and infectious diseases. A webcast and replay will be accessible on their official website. Molecular Partners AG aims to address challenges that existing drug modalities cannot, with several compounds in various stages of development.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) announced the initiation of a Phase 1 first-in-human study for its candidate MP0533, targeting acute myeloid leukemia (AML). The trial will assess the safety, tolerability, and efficacy of MP0533, which employs a novel mechanism that selectively engages CD3 on T cells when binding two or three tumor-associated antigens. This approach aims to enhance targeting of leukemic cells while sparing healthy ones. The study plans to enroll 20-45 patients with relapsed/refractory AML across five sites in Switzerland and the Netherlands.
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