Matinas BioPharma Provides Positive Outcomes Update on the MAT2203 Compassionate/Expanded Use Access Program, Including Multiple Patients with Complete Clinical Resolution

Rhea-AI Summary

Matinas BioPharma (MTNB) provides a positive update on its Compassionate/Expanded Use Access Program with MAT2203, showing promising results in treating invasive fungal infections. Out of 19 patients enrolled, those completing treatment had complete clinical resolution, with significant improvements seen in others. MAT2203 demonstrated efficacy in patients with limited treatment options, addressing a significant medical need.

Medical Research Analyst

The data presented on MAT2203's Compassionate/Expanded Use Access Program signifies a potential breakthrough in the treatment of invasive fungal infections, particularly for patients with limited options due to drug resistance or intolerance. The complete clinical resolution in all five patients who completed treatment is a notable outcome, suggesting MAT2203's efficacy. Furthermore, the reversal of renal impairment in patients previously treated with AmBisome is a significant finding, as nephrotoxicity is a common concern with antifungal treatments. These results may indicate a lower toxicity profile for MAT2203, which could lead to broader usage and impact on patient care.

From a research perspective, the variety of infections treated and the range of treatment durations provide a robust dataset for evaluating MAT2203's effectiveness across different scenarios. The continued clinical improvement in ongoing cases strengthens the argument for the drug's potential. However, it is crucial to consider that these results are from a limited sample size and under a compassionate use setting, which may not fully represent the outcomes in a larger, controlled clinical trial.

Financial Analyst

Matinas BioPharma's update on their LNC-delivered oral formulation of amphotericin B, MAT2203, could have positive implications for the company's financial health if the drug continues to show promise. The successful treatment outcomes and improvement in renal function could position MAT2203 as a preferred alternative to existing antifungal treatments, potentially leading to increased market share and revenue for Matinas BioPharma. Investors might view this news as a signal of the company's innovation and growth potential, particularly given the unmet medical need in this area.

It is essential to monitor the progression of MAT2203 through the regulatory pathway and any partnerships or licensing deals that may arise as a result of these positive outcomes. The stock market typically reacts favorably to clinical advancements, especially for treatments that address significant unmet needs. However, the long-term financial impact will hinge on regulatory approval, market adoption and the competitive landscape.

Pharmaceutical Market Analyst

The positive outcomes reported for MAT2203 could disrupt the current antifungal drug market. The drug's unique delivery system and apparent reduction in renal toxicity are key differentiators that may give it an edge over competitors, especially in cases where patients have pre-existing renal issues or are at high risk for nephrotoxicity. As drug resistance continues to be a major challenge in antifungal therapy, a new treatment with a favorable resistance profile could capture significant market share.

Understanding the market dynamics and potential demand for MAT2203 is crucial. The drug's success in treating a range of fungal infections, including those resistant to other therapies, suggests a broad potential application. However, the actual market impact will depend on factors like pricing, insurance coverage and the ability of Matinas BioPharma to effectively market and distribute the drug post-approval.

A total of 19 patients with serious/life-threatening invasive fungal infections have been enrolled, including aspergillosis, mucormycosis, fusarium, candidiasis, cryptococcosis, and endemic mycoses such as coccidioidomycosis and histoplasmosis

All 5 patients who completed the desired course of treatment had complete clinical resolution of their infection; patients with ongoing treatment continue to experience significant clinical improvement

All patients who transitioned to MAT2203 after developing renal toxicity following treatment with AmBisome^® (liposomal amphotericin B) saw a reversal of renal impairment with a return to baseline renal function with no subsequent renal issues

BEDMINSTER, N.J., Feb. 26, 2024 (GLOBE NEWSWIRE) -- Matinas BioPharma (NYSE American: MTNB), a clinical-stage biopharmaceutical company focused on delivering groundbreaking therapies using its lipid nanocrystal (LNC) platform delivery technology, today provided an update from its ongoing Compassionate/Expanded Use Access Program (the “Program”) with MAT2203, the Company’s proprietary, LNC-delivered oral formulation of the broad-spectrum antifungal drug amphotericin B.

To date, 19 patients have been enrolled in the Program at prestigious healthcare institutions, including the University of Michigan, Johns Hopkins, Nationwide Children’s Hospital, City of Hope, Vanderbilt University Medical Center, the National Institutes of Health, Children’s Hospital of Philadelphia, Memorial Sloan Kettering Cancer Center, and the University of California, San Diego School of Medicine.

The majority of enrolled patients are post-transplant or are undergoing treatment for underlying malignancies. The infections being treated with MAT2203 include a variety of micro-organisms (including Aspergillus, Mucorales species, Candidiasis, Fusarium and suspected Coccidioides) occurring at multiple sites of infection, including brain, bladder/colon, bone, lung, sinus, and skin. Most patients were receiving AmBisome prior to enrollment but developed treatment-limiting nephrotoxicity and most also required treatment for either azole-resistant organisms or had clinically failed azole therapy and had no other treatment options.

“We are encouraged by the positive clinical impact of MAT2203 in each of our patients who faced few or no treatment options,” said Dr. Marisa Miceli, an internationally recognized infectious disease physician specializing in the treatment of invasive fungal infections and Professor of Medicine in the Division of Infectious Diseases at the University of Michigan. “Of the seven patients we have treated to date under the Program, all were either unable to receive azole therapy due to drug-drug interactions, intolerance or resistance and some of them experienced serious treatment-limiting toxicities while attempting therapy with IV-administered amphotericin B. Treatment with MAT2203 was well tolerated and led to favorable clinical and radiological response and we did not observe any renal toxicity. While additional study is warranted, MAT2203 may be particularly promising for the treatment of invasive fungal infections in patients with limited options and therefore satisfy a currently significant unmet medical need.”

Of the 19 patients enrolled in the Program, 15 have available follow-up and 4 recently initiated or will soon commence treatment with MAT2203.

• 12 of the 15 patients had either complete clinical resolution or objective improvement in clinical markers of infection (including radiologic and mycologic).
• Of the 5 patients who completed their full individually specified course of treatment (ranging from 2 weeks to 1 year, depending on the infection) all have had complete clinical resolution with no relapses or recurrence of their infection.
• 5 additional patients have shown objective improvement in clinical markers and are continuing treatment with MAT2203 as planned.
• 5 of the 15 patients were unable to complete their individually specified course of treatment, although 2 saw significant clinical improvement of their fungal infection and are included in the 12 overall successful cases.
  • 2 patients transitioned to palliative care shortly after starting therapy with MAT2203 because of unanticipated progression of their malignant disease.
  • 1 patient discontinued therapy after two days due to underlying GI issues (i.e., Crohn’s disease).
  • 1 patient passed away due to progression of their underlying disease approximately 8 weeks into therapy (but previously experienced significant clinical improvement of their fungal infection).
  • 1 patient discontinued MAT2203 treatment following 10 weeks of therapy due to underlying GI issues (long-standing nausea/vomiting), but with improvement in their fungal infection.

Importantly, all patients who experienced renal toxicity following treatment with AmBisome saw their renal function return to baseline after transitioning to MAT2203 therapy and suffered no further renal side effects over the course of extended treatment with MAT2203.

“We continue to be excited about the ongoing, consistent positive clinical impact of MAT2203, seen in these extremely ill patients,” said Theresa Matkovits, PhD, Chief Development Officer at Matinas. “We look forward to advancing MAT2203 into Phase 3 development in the ORALTO registration trial and to validating these results in a well-controlled clinical trial in which we believe the clinical probability of success is quite high. If approved, oral, effective, and safe MAT2203 could represent a dramatic improvement to current clinical standard of care and become the treatment of choice for patients and physicians battling invasive fungal infections. We are grateful to the participants in the Program and to their physicians for recognizing the clinical potential of MAT2203 in treating a broad spectrum of deadly invasive fungal infections.”

MAT2203 is not yet licensed or approved anywhere globally.

About MAT2203
Matinas BioPharma is developing MAT2203 as a potential oral broad-spectrum treatment for invasive deadly fungal infections. Although amphotericin B is a fungicidal agent, it is currently only available through an intravenous route of administration, which is known to be associated with several significant safety issues such as renal toxicity and anemia due to very high circulating levels of amphotericin B. MAT2203 has the potential to overcome the significant limitations of the currently available amphotericin B products due to its targeted oral delivery. Combining comparable fungicidal activity with targeted delivery results in a lower risk of toxicity and potentially creates the ideal antifungal agent for the treatment of invasive fungal infections. MAT2203 was successfully evaluated in the completed Phase 2 EnACT study in HIV patients suffering from cryptococcal meningitis, meeting its primary endpoint, and achieving robust survival. MAT2203 will be further evaluated in a single Phase 3 registration trial (the “ORALTO” trial) as an oral step-down monotherapy following treatment with AmBisome (liposomal amphotericin B) compared with the standard of care in patients with invasive aspergillosis who have limited treatment options.

About Matinas BioPharma
Matinas BioPharma is a biopharmaceutical company focused on delivering groundbreaking therapies using its lipid nanocrystal (LNC) platform delivery technology.

In addition to MAT2203, preclinical and clinical data have demonstrated that this novel technology can potentially provide solutions to many challenges of achieving safe and effective intracellular delivery of both small molecules and larger, more complex molecular cargos including small oligonucleotides such as ASOs and siRNA. The combination of its unique mechanism of action and flexibility with routes of administration (including oral) positions Matinas’ LNC technology to potentially become a preferred next-generation orally available intracellular drug delivery platform. For more information, please visit www.matinasbiopharma.com.

Forward-looking Statements
This release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including those relating to our business activities, our strategy and plans, the future development of its product candidates, including MAT2203, the Company’s ability to identify and pursue development, licensing and partnership opportunities for its products, including MAT2203, or platform delivery technology on favorable terms, if at all, and the ability to obtain required regulatory approval and other statements that are predictive in nature, that depend upon or refer to future events or conditions. All statements other than statements of historical fact are statements that could be forward-looking statements. Forward-looking statements include words such as "expects," "anticipates," "intends," "plans," "could," "believes," "estimates" and similar expressions. These statements involve known and unknown risks, uncertainties and other factors which may cause actual results to be materially different from any future results expressed or implied by the forward-looking statements. Forward-looking statements are subject to a number of risks and uncertainties, including, but not limited to, our ability to continue as a going concern, our ability to obtain additional capital to meet our liquidity needs on acceptable terms, or at all, including the additional capital which will be necessary to complete the clinical trials of our product candidates; our ability to successfully complete research and further development and commercialization of our product candidates; the uncertainties inherent in clinical testing; the timing, cost and uncertainty of obtaining regulatory approvals; our ability to protect the Company’s intellectual property; the loss of any executive officers or key personnel or consultants; competition; changes in the regulatory landscape or the imposition of regulations that affect the Company’s products; and the other factors listed under "Risk Factors" in our filings with the SEC, including Forms 10-K, 10-Q and 8-K. Investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this release. Except as may be required by law, the Company does not undertake any obligation to release publicly any revisions to such forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. Matinas BioPharma’s product candidates are all in a development stage and are not available for sale or use.

Investor Contact

LHA Investor Relations
Jody Cain
Jcain@lhai.com
310-691-7100

How many patients have been enrolled in Matinas BioPharma's Compassionate/Expanded Use Access Program?

A total of 19 patients have been enrolled in the Program.

What is the ticker symbol for Matinas BioPharma?

The ticker symbol for Matinas BioPharma is MTNB.

What is the name of the LNC-delivered oral formulation used by Matinas BioPharma in the Program?

The LNC-delivered oral formulation used is MAT2203.

Which healthcare institutions are involved in the Program?

Prestigious healthcare institutions such as the University of Michigan, Johns Hopkins, and others are participating.

What positive clinical impact did MAT2203 have on patients?

Patients experienced complete clinical resolution, significant clinical improvement, and reversal of renal impairment after transitioning to MAT2203.