New Meta-Analysis Demonstrates that Access to the GeneSight Test Can Significantly Improve Response and Remission Rates for Patients with Depression

Rhea-AI Summary

Myriad Genetics (NASDAQ: MYGN) announced significant findings from a meta-analysis of six prospective controlled studies involving 3,532 adults with major depressive disorder (MDD). The analysis, published in the Journal of Clinical Psychopharmacology, demonstrated that patients whose clinicians had access to GeneSight® Psychotropic test results showed markedly improved outcomes compared to traditional treatment.

The study revealed that patients in the GeneSight arm were 41% more likely to achieve remission and 30% more likely to achieve response compared to treatment as usual (TAU). The company plans to submit this data to payers to increase patient access to the GeneSight test.

Insights

Molecular Diagnostics Specialist

New meta-analysis strongly validates Myriad's GeneSight test effectiveness for depression treatment, potentially boosting reimbursement and adoption.

The newly published meta-analysis of Myriad Genetics' GeneSight Psychotropic test represents a significant clinical validation milestone for the company's precision medicine approach to depression treatment. By analyzing data from six prospective controlled studies with 3,532 adults suffering from major depressive disorder (MDD), the research demonstrated that patients whose clinicians had access to GeneSight test results were 41% more likely to achieve remission and 30% more likely to achieve response compared to treatment as usual.

This robust evidence carries substantial commercial implications. Depression affects approximately 21 million American adults annually, with many cycling through multiple medication trials before finding effective treatment. The GeneSight test analyzes how genetic variations affect response to medications, potentially reducing this trial-and-error approach.

The company's explicit statement about submitting this data to payers signals the strategic importance of these findings. Enhanced insurance coverage would address a key adoption barrier, as genetic testing reimbursement remains challenging. The endorsement from a University of Michigan Depression Center expert adds further credibility to these findings.

From a market perspective, this strengthens Myriad's position in the growing pharmacogenomics space. The GeneSight test is a critical component of Myriad's portfolio diversification strategy beyond its hereditary cancer tests. With these compelling clinical utility data, Myriad now has stronger evidence to drive both clinician adoption and payer coverage, potentially accelerating revenue growth for this product line.

Results published in the Journal of Clinical Psychopharmacology

SALT LAKE CITY, Sept. 03, 2025 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc., (NASDAQ: MYGN), a leader in molecular diagnostic testing and precision medicine, today announced the publication of a new meta-analysis of six prospective controlled studies¹ that included 3,532 adults with major depressive disorder (MDD). The meta-analysis showed that when GeneSight^® Psychotropic test results were available to treating clinicians, there were significant improvements in response and remission rates for patients with MDD, compared to treatment as usual (TAU).

Specifically, compared to TAU, patients in the GeneSight arm were:

• 41% more likely to achieve remission.
• 30% more likely to achieve response.

“This meta-analysis summarizes the clinical evidence of the GeneSight test, demonstrating superiority over treatment as usual—which often involves repeated medication trials,” said Sagar V. Parikh, M.D., FRCPC, study author, professor of psychiatry at the University of Michigan, associate director of the University of Michigan Depression Center. “This study found that the GeneSight test can be a powerful tool to augment a clinician’s knowledge, experience and passion for their patients’ recovery.”

The large-scale data analysis—merging data over many independent studies—provides evidence of the clinical utility of the GeneSight Psychotropic test for patients with MDD who have experienced at least one treatment failure.

“Depression is not just a mental health issue—it’s a public health priority. If we want to improve overall outcomes and enhance quality of life, we must treat depression with the same urgency and resources as any other chronic condition,” said Dale Muzzey, PhD, chief scientific officer, Myriad Genetics. “This meta-analysis adds to our confidence in the clinical validity and utility of the GeneSight test.”

Myriad Genetics plans to submit this data to payers as part of ongoing efforts to increase patient access to the GeneSight test and help patients achieve remission from depression.

About the Meta-Analysis
The study analyzed six prospective, controlled trials to assess the impact of the GeneSight Psychotropic test on clinical outcomes in a total of 3,532 unique adults with MDD who had at least one prior treatment failure. The trials included in the meta-analysis incorporated the widely used depression questionnaires, the Hamilton Depression Rating Scale (HAM-D17) and the Patient Health Questionnaire (PHQ-9), to assess severity of depression symptoms. Response was defined as a 50% or greater improvement in depression scores from baseline to endpoint. Remission was defined as a score of seven or less on the HAM-D17 or a score of five or less on the PHQ-9.

^{1 Pine Rest (Winner et al., 2013), Hamm (Hall-Flavin et al., 2012), La Crosse (Hall-Flavin et al., 2013), GUIDED (Greden et al., 2019), PRIME Care (Oslin et al., 2022), GAPP-MDD (Tiwari et al., 2022)}

About the GeneSight^® Test
The GeneSight Psychotropic test from Myriad Genetics is the category-leading pharmacogenomic test for 64 medications commonly prescribed for depression, anxiety, ADHD, and other psychiatric conditions. The GeneSight test can help inform clinicians about how a patient’s genes may impact how they metabolize and/or respond to certain psychiatric medications. It is designed to provide information that may help reduce the trial-and-error process that often takes place when patients are prescribed certain mental health medications. Learn more at www.genesight.com.

About Myriad Genetics 
Myriad Genetics is a leading molecular diagnostic testing and precision medicine company dedicated to advancing health and well-being for all. Myriad Genetics develops and offers molecular tests that help assess the risk of developing disease or disease progression and guide treatment decisions across medical specialties where molecular insights can significantly improve patient care and lower healthcare costs. For more information, visit www.myriad.com.

Safe Harbor Statement
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements related to the meta-analysis and how it adds to the company’s confidence in the clinical validity and utility of the GeneSight test, as well as the company’s plans to submit data from the meta-analysis to payors as part of ongoing efforts to increase patient access to the GeneSight test and help patients achieve remission from depression. These “forward-looking statements” are management’s expectations of future events as of the date hereof and are subject to known and unknown risks and uncertainties that could cause actual results, conditions, and events to differ materially and adversely from those anticipated. Such factors include those risks described in the company’s filings with the U.S. Securities and Exchange Commission, including the company’s Annual Report on Form 10-K filed on February 28, 2025, as well as any updates to those risk factors filed from time to time in the company’s Quarterly Reports on Form 10-Q or Current Reports on Form 8-K. Myriad is not under any obligation, and it expressly disclaims any obligation, to update or alter any forward-looking statements, whether as a result of new information, future events or otherwise except as required by law. 

Investor Contact 
Matt Scalo 
(801) 584-3532 
IR@myriad.com 

Media Contact 
Kate Schraml
(224) 875-4493
PR@myriad.com

FAQ

What are the key findings of Myriad Genetics' (MYGN) GeneSight test meta-analysis?

The meta-analysis showed patients using GeneSight were 41% more likely to achieve remission and 30% more likely to achieve response compared to traditional treatment.

How many patients were included in the MYGN GeneSight meta-analysis study?

The meta-analysis included 3,532 adults with major depressive disorder (MDD) across six prospective controlled studies.

What is Myriad Genetics' (MYGN) plan for the GeneSight test results?

Myriad Genetics plans to submit the data to payers to increase patient access to the GeneSight test and help more patients achieve remission from depression.

How does the GeneSight test improve depression treatment outcomes?

The GeneSight test serves as a powerful tool to augment clinicians' knowledge, helping them make better treatment decisions for patients who have experienced at least one treatment failure.

What is the clinical significance of MYGN's GeneSight test for depression treatment?

The test demonstrates superior outcomes over traditional treatment, providing evidence of clinical utility for MDD patients who have experienced treatment failure.