Nektar Therapeutics reports developments as a clinical-stage biotechnology company developing immunology therapies for autoimmune and chronic inflammatory diseases. Company news centers on rezpegaldesleukin, also known as REZPEG or NKTR-358, a regulatory T cell stimulator evaluated across disease areas including atopic dermatitis, alopecia areata, and Type 1 diabetes mellitus.
Recurring updates also cover Nektar's preclinical pipeline, including TNFR2 antibody and bispecific programs NKTR-0165 and NKTR-0166, and the modified hematopoietic colony stimulating factor protein NKTR-422. Financial results, public equity offerings, shelf-registration activity, employee inducement grants, and other capital and governance actions are regular news themes for NKTR.
Summary not available.
Summary not available.
Summary not available.
Summary not available.
Summary not available.
Summary not available.
Summary not available.
Summary not available.
Nektar Therapeutics (NASDAQ: NKTR) announced on April 27, 2023, its intention to regain full rights to REZPEG from Eli Lilly, moving forward with a Phase 2b clinical study for atopic dermatitis in 2023. Previously presented Phase 1b data showcased significant improvements in efficacy measures such as EASI and vIGA-AD scores, lasting for an additional 36 weeks post-treatment. The company aims to explore REZPEG's potential in other autoimmune conditions as well. CEO Howard W. Robin expressed optimism about REZPEG's innovative mechanism and immune-modulatory profile, highlighting its potential to provide long-term disease control for patients. The company believes REZPEG may offer hope for those suffering from atopic dermatitis, a prevalent and debilitating condition affecting approximately 16.5 million U.S. adults.
Nektar Therapeutics announced a strategic reprioritization and cost restructuring plan focusing on immunology research, specifically on the development of REZPEG for atopic dermatitis and NKTR-255 for oncology. The workforce in San Francisco will be reduced by approximately 60%, aiming for a cash runway extension into mid-2026. The company reported cash and equivalents of about $456 million as of March 31, 2023, expecting annual savings of around $30 million by 2024 from the workforce cut. Nektar plans to continue core immunology programs and pursue strategic partnerships for NKTR-255. The first quarter 2023 financial results will be announced on May 9, 2023.