Welcome to our dedicated page for NeuroSense Therapeutics Ltd. news (Ticker: NRSN), a resource for investors and traders seeking the latest updates and insights on NeuroSense Therapeutics Ltd. stock.
NeuroSense Therapeutics Ltd. (NASDAQ: NRSN) is a clinical-stage biotechnology company focused on discovering and developing treatments for patients suffering from debilitating neurodegenerative diseases. These diseases encompass Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, and Parkinson's disease, among others.
The company's flagship product, PrimeC, is a novel extended-release oral formulation, combining ciprofloxacin and celecoxib in a specific ratio designed for synergistic effect. PrimeC aims to target several key mechanisms of ALS, including motor neuron degeneration, inflammation, iron accumulation, and impaired RNA regulation. The formulation has shown promising results in clinical trials, including a significant slowing of disease progression in Phase 2b studies.
In their recent PARADIGM Phase 2b clinical trial, NeuroSense demonstrated compelling data with a 37% reduction in the progression of ALS, with further subgroup analysis showing even higher efficacy in specific patient populations. This trial's success propelled the company towards preparing for a Phase 3 pivotal trial, with extensive collaboration and validation from industry experts.
NeuroSense has been active in forming strategic partnerships to enhance its research and development capabilities. Notable collaborations include agreements with Lonza for biomarker development, and Genetika+ for Alzheimer's disease drug development. These partnerships leverage cutting-edge technologies to optimize clinical outcomes and advance the company's therapeutic solutions.
Financially, NeuroSense reported an increase in R&D expenses from $6.4 million in 2022 to $7.6 million in 2023, reflecting its investment in expanding its workforce and clinical programs. Conversely, general and administrative expenses saw a decrease, contributing to an efficient allocation of resources. As of December 31, 2023, the company had a cash position of approximately $2.6 million.
With multiple ongoing projects and a robust pipeline, NeuroSense is set to play a significant role in addressing the unmet medical needs in neurodegenerative diseases. The company's dedication to advancing research and developing novel therapies positions it as a key player in biotech innovation.
For more information, visit NeuroSense's investor relations website at https://neurosense.investorroom.com/.
NeuroSense has announced positive results from its 12-month PARADIGM Phase 2b study of PrimeC in ALS patients, showing a significant improvement in complication-free survival. Specifically, the study demonstrated a 57% difference in favor of PrimeC over placebo in the ITT population, and a 73% difference in the PP population. PrimeC also slowed disease progression by 36% and improved survival rates by 43% in prior reports. Additional data points showed improvements in Slow Vital Capacity and ALSFRS-R scores. These results will be submitted to the FDA to discuss the future of PrimeC. NeuroSense is optimistic about the potential of PrimeC as a treatment for ALS.
NeuroSense Therapeutics announced promising results from its PARADIGM Phase 2b study on PrimeC for ALS treatment. The 12-month data showed a 36% slower disease progression for participants on PrimeC compared to placebo (p=0.009). PrimeC also improved survival rates by 43%. Further analysis indicated a 40% improvement in ALSFRS-R scores and a 63% boost in survival for the per-protocol population on PrimeC. These findings support advancing to Phase 3 trials in the U.S. and Europe to further evaluate PrimeC's efficacy as a disease-modifying drug for ALS.
NeuroSense Therapeutics (NASDAQ: NRSN) announced a corporate update and Q1 2024 financial results. Their Phase 2b PARADIGM clinical trial showed a significant 43% slowing of disease progression in high-risk ALS patients treated with PrimeC. Upcoming milestones include 12-month clinical results in June 2024 and an FDA meeting in Q3 2024. Financially, the company reported stable R&D and administrative expenses at $1.88M and $1.11M, respectively. However, it faced a net loss of $5.4M for the quarter, with cash reserves at $0.74M as of March 31, 2024. Additional funding of $4.5M was secured in April 2024 through a direct offering.
NeuroSense Therapeutics (Nasdaq: NRSN) has received a delisting notice from Nasdaq due to non-compliance with the minimum $2,500,000 stockholders' equity requirement, as per Listing Rule 5550(b). The company must request a hearing before a Nasdaq Hearings Panel to stay the delisting process. NeuroSense plans to present its compliance strategy during the hearing. The Panel can grant an extension until December 18, 2024, for the company to meet the equity requirement and maintain its listing status.
NeuroSense Therapeutics (NASDAQ: NRSN) announced that its VP of R&D, Dr. Shiran Zimri, will present at the 3rd Annual ALS Drug Development Summit in Boston on May 22, 2024. Dr. Zimri will discuss the potentials of combination therapy in ALS and share the latest progress on PrimeC, NeuroSense's investigational treatment. Recent results from the phase 2b PARADIGM trial showed a 43% slowing of disease progression in high-risk ALS patients treated with PrimeC compared to placebo over 6 months, with a significant 5.04-point difference in ALSFRS-R scores.
NeuroSense Therapeutics (Nasdaq: NRSN) has partnered with PhaseV to optimize its Phase 3 trial of PrimeC for ALS using advanced causal machine learning. PhaseV's analysis of NeuroSense's PARADIGM Phase 2b study predicted high success probabilities in multiple subgroups for the Phase 3 trial. PhaseV's insights will inform study design, patient enrollment, and cost-effectiveness. NeuroSense’s recent Phase 2b data showed PrimeC slowed disease progression by 37% and 43% in high-risk patients. The company plans to submit its End of Phase 2 package to the FDA and EMA soon.
NeuroSense Therapeutics announces positive data analysis from the PARADIGM clinical trial, showing a 43% slowing of disease progression in high-risk ALS patients treated with PrimeC. The study demonstrated consistent results across subgroups, indicating the potential of PrimeC to redefine ALS treatment. The CEO expressed optimism and highlighted the significant impact of PrimeC on patients, with plans to use the data for the upcoming pivotal trial.
NeuroSense Therapeutics (Nasdaq: NRSN) provides a business update for Q1 2024, highlighting key collaborations and positive results from the PARADIGM Study in ALS and Alzheimer's disease. The company is focused on advancing its treatments for neurodegenerative diseases, with plans for further research and clinical trials in the coming months.
FAQ
What is NeuroSense Therapeutics' main focus?
What is PrimeC?
What were the results of the PARADIGM Phase 2b trial?
Who are NeuroSense's key collaborators?
What are the financial highlights for NeuroSense in 2023?
What diseases is NeuroSense targeting?
What is the status of PrimeC's clinical trials?
How does PrimeC work?
Is PrimeC FDA approved?
How can I get more information about NeuroSense?
