Nrx Pharmaceuticals Inc Stock Price, News & Analysis

NRx Pharmaceuticals (Nasdaq: NRXP) has announced the retirement of CEO Jonathan Javitt, effective immediately. Robert Besthof, the company's Chief Commercial Officer, is appointed as Interim CEO while the Board searches for a permanent replacement. Besthof brings extensive experience from Pfizer and Eli Lilly, and will focus on advancing NRx's pipeline and strategic initiatives, particularly concerning ZYESAMI® for COVID-19 and the NRX-101 psychiatric portfolio. Javitt will transition to a consulting role as Chief Scientist.

NRx Pharmaceuticals (Nasdaq: NRXP) announced a positive review from the DSMB regarding its ZYESAMI® (aviptadil) treatment for critically ill COVID-19 patients in the Phase 3 ACTIV-3b trial. The trial has enrolled 448 patients, achieving over 80% of its target. No serious adverse events related to ZYESAMI were reported, bolstering its safety profile among more than 800 treated patients. Following the discontinuation of another study arm, ZYESAMI remains the sole investigational drug in the ACTIV-3 trial. NRx plans to provide further updates on its Phase 2b/3 trial findings soon.

NRx Pharmaceuticals (Nasdaq: NRXP) has reported remarks by Dr. Shmuel Yitzhaki of the Israel Institute for Biological Research, indicating their BriLife vaccine may demonstrate superior neutralizing ability against the Omicron variant relative to the Pfizer vaccine. Despite a three-fold decrease in efficacy, it outperforms Pfizer's 8 to 20 fold reduction. The scalable, modular vaccine technology shows potential for adaptability to new variants. NRx has received 173 million shekels in funding for this project, which is carried out by 80 staff members, indicating efficient resource use compared to other firms.

NRx Pharmaceuticals (NRXP) announced the closure of a private placement resulting in $25 million in gross proceeds. The offering included 7,824,727 shares of common stock and investment options exercisable at $3.07 per share. The shares were sold at a price of $3.195 each, a premium over market value. The offering was facilitated by H.C. Wainwright & Co. The company is actively developing treatments for COVID-19 and bipolar depression, with ongoing clinical trials and regulatory designations, including Fast Track and Breakthrough Therapy Designation.

NRx Pharmaceuticals (NRXP) has announced a private placement to sell 7,824,727 shares of common stock at $3.195 each, along with unregistered investment options for the same number of shares at an exercise price of $3.07. The expected gross proceeds are approximately $25 million, set to close around February 2, 2022. The funds will be directed towards advancing their three therapies, including the COVID-19 treatment, ZYESAMI. H.C. Wainwright & Co. acts as the exclusive placement agent for this offering.

NRx Pharmaceuticals (NASDAQ: NRXP) announced that the BriLife® vaccine shows potential effectiveness against the Omicron variant of SARS-CoV-2, according to findings from the Israel Institute for Biological Research (IIBR). The vaccine demonstrated a mean neutralization titer of 53 against Omicron, compared to 152 against the original virus. The IIBR concluded that BriLife®-induced antibodies maintain neutralizing potential against all tested variants. NRx aims to test BriLife as a booster in a phase 2 trial across Israel and other partner countries.

On January 26, 2022, NRx Pharmaceuticals (NRXP) announced a safety report from a Southwestern hospital regarding ZYESAMI® (Aviptadil) treatment for COVID-19 respiratory failure under the Right to Try Law. Of the first 19 patients treated by December 31, 2021, three died, while 16 (84%) were reported alive by January 22, 2021, with 14 discharged. No Serious Adverse Events linked to ZYESAMI were reported. The data will support an FDA Emergency Use Authorization application for critical COVID-19 patients. ZYESAMI is also undergoing trials in the NIH-sponsored ACTIV-3b trial.

NRx Pharmaceuticals (Nasdaq: NRXP) announced enhancements to its Expanded Access and Right to Try programs for ZYESAMI® (aviptadil), aimed at providing treatment for COVID-19 patients with respiratory failure who have not responded to other therapies. As manufacturing capacity increases via Nephron Pharmaceuticals, ZYESAMI will be more widely available to hospitals under FDA guidelines. The NIH is conducting the Phase 3 ACTIV-3b trial, with participants showing improved recovery odds. ZYESAMI is not FDA-approved but remains a critical option amid current healthcare challenges.

NRx Pharmaceuticals (NRXP) has responded to allegations by Relief Therapeutics concerning false statements and failure to provide financial records. NRx asserts that it has not accused Relief's management of criminal behavior, clarifying misunderstandings around previous statements. Asserting compliance, NRx indicates that it provided over 1,000 pages of financial documents before the mediation date. NRx anticipates mediation on February 22, 2022, to address claims of breach of contract by Relief, arguing that the latter's accusations are attempts to distract from its obligations under their collaboration agreement.