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NeOnc CEO Adds Another 70,000 Shares as Insider Buying Continues

The CEO’s reported beneficial ownership increased to approximately 7.77 million shares, including holdings through affiliated entities.

Sentiment and the balance of points

Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.

Tags

NeOnc Technologies Holdings (NASDAQ:NTHI) CEO Amir Heshmatpour purchased another 70,000 common shares on November 5 and 6 for approximately $230,510. He bought 30,000 shares at a weighted average price of approximately $3.17 and 40,000 at approximately $3.39, respectively. His reported beneficial ownership rose to approximately 7.77 million shares, including affiliated-entity holdings.

The purchases follow a November 5 update disclosing that Heshmatpour and Thomas C. Chen had bought a combined 160,016 shares for approximately $629,000 following NEO100 Phase 2a results. Reported in August, that study met its primary endpoint: six-month progression-free survival, or survival without disease worsening, was 48.9% against a prespecified 20% benchmark (p=0.0047). Updated NEO100 data and Phase 1 findings for NEO212, an investigational central nervous system cancer therapy, are scheduled for presentation November 13 at the Society for Neuro-Oncology annual meeting.

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3 points · 1 major

How this balance works

Rhea-AI gives every point it takes from this document a weight. Minor counts 1, Moderate 3 and Major 9, so one Major point outweighs several Minor ones. The bar adds up the weights on each side, and when neither side holds more than 65% of the total the balance reads Mixed.

It reads the document as published, with the same rules for every company, and it does not look at what the market expected or at how the stock traded, so a point can be objectively good on a day the stock falls.

Rhea-AI Sentiment measures something else, the tone of the wording.

0 major · 0 points

How the balance works

Positive

  • Major pointNEO100 Phase 2a met its primary endpoint: 48.9% six-month progression-free survival versus a prespecified 20% benchmark (p=0.0047).
  • Minor pointCEO Amir Heshmatpour purchased 70,000 shares for approximately $230,510 on November 5 and 6.
  • Minor pointEarlier disclosed insider purchases totaled 160,016 shares for approximately $629,000 by Heshmatpour and Thomas C. Chen.

Negative

  • None.
Argus 15 min delay 3 alerts
+7.19% vs previous close $3.74 last price 5.2x rel. volume Open Argus
Details

Market move: NTHI +7.19% vs previous close. CEO share purchase

$3.59 – $3.90 Day Range
$107.92M Mkt Cap at Last Price

On Nov 9, the day this news came out, the latest delayed price for NTHI is 7.19% above the previous close. Our momentum scanner has recorded 3 alerts for this stock so far that day. The latest delayed price is $3.74. Relative volume is exceptionally heavy at 5.2x what this stock usually trades by this time of day.

Data tracked by StockTitan Argus (15 min delayed). Upgrade to Gold for real-time data.

Key Figures

CEO share purchase: 70,000 shares Earlier insider purchases: 160,016 shares Six-month progression-free survival: 48.9% +2 more
CEO share purchase
70,000 shares
Purchases on November 5 and 6
Earlier insider purchases
160,016 shares
Combined purchases disclosed in the November 5 quarterly update
Six-month progression-free survival
48.9%
NEO100 Phase 2a study
Prespecified benchmark
20%
NEO100 Phase 2a study comparison
P-value
p=0.0047
NEO100 Phase 2a primary endpoint result

Historical Context

1 past event · Latest: Nov 05
1 event
  1. Nov 05

    Quarterly update

    24h Move
    +0.9%

    Reported earlier insider purchases alongside NEO100 Phase 2a results meeting its primary endpoint.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Key Terms

form 4, weighted average price, beneficial ownership, progression-free survival, +1 more
5 terms
form 4 regulatory
"according to a newly filed SEC Form 4"
Form 4 is a official document that company insiders, such as executives or major shareholders, file with regulators whenever they buy or sell company shares. It provides transparency about how those with inside knowledge are trading, helping investors see if insiders are confident in the company's prospects or may be selling for personal reasons. This information can influence investor decisions by revealing insiders' perspectives on the company's value.
View in glossary
weighted average price financial
"at a weighted average price of approximately $3.17"
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
beneficial ownership financial
"His reported beneficial ownership increased"
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
View in glossary
progression-free survival medical
"achieving six-month progression-free survival of 48.9%"
Progression-free survival is the length of time during and after a treatment that a patient's disease does not get worse, measured from the start of treatment until the disease shows measurable signs of progression or the patient dies. Investors care because longer progression-free survival in clinical trials often signals that a drug is effective, improving chances of regulatory approval, market adoption, and revenue potential—think of it as a stopwatch showing how long a therapy can keep the illness at bay.
idh1-mutant medical
"recurrent IDH1-mutant high-grade glioma"
An IDH1‑mutant is a version of the cellular enzyme IDH1 that has a specific genetic change causing it to act differently than normal. Like a light switch stuck halfway, the altered enzyme creates abnormal chemicals that can drive certain cancers and serve as a clear disease fingerprint. Investors watch IDH1‑mutant status because it creates opportunities for targeted drugs, diagnostic tests, and companion therapies that can change treatment pathways and company value.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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DALLAS, Nov. 09, 2026 (GLOBE NEWSWIRE) -- (www.InvestorsTape.com) — NeOnc Technologies Holdings (NASDAQ:NTHI) CEO Amir Heshmatpour has purchased another 70,000 shares of the company's common stock for approximately $230,510, according to a newly filed SEC Form 4.

The transactions took place on November 5 and 6, with Heshmatpour purchasing 30,000 shares at a weighted average price of approximately $3.17 on the first day and another 40,000 shares at approximately $3.39 on the second. His reported beneficial ownership increased to approximately 7.77 million shares, including holdings through affiliated entities.

This is not an isolated show of confidence. Heshmatpour has repeatedly purchased shares in the open market during 2026, including purchases in August and September. In its November 5 quarterly update, NeOnc disclosed that Heshmatpour and fellow insider Thomas C. Chen had purchased a combined 160,016 shares for approximately $629,000 following the company's positive Phase 2a NEO100 results.

The latest purchases add another $231,000 to that buying pattern and are particularly noteworthy given the company's upcoming clinical catalysts.

NeOnc is developing NEO100, an intranasal treatment candidate for recurrent IDH1-mutant high-grade glioma, and NEO212, an investigational therapy for central nervous system cancers. The company reported in August that its NEO100 Phase 2a study met its primary endpoint, achieving six-month progression-free survival of 48.9%, compared with a prespecified 20% benchmark (p=0.0047).

Updated NEO100 data and NEO212 Phase 1 findings are scheduled for presentation at the Society for Neuro-Oncology annual meeting on November 13.

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Forward-Looking Statements

This press release contains forward-looking statements within the meaning of applicable securities laws, including statements that may regard NeOnc Technologies Holdings’ future revenue, growth trajectory, profitability outlook, expansion plans, strategic partnerships, potential regulatory approvals, and other projections, plans, and objectives. Forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those expressed or implied, including market conditions, timing of venue openings, execution risks, operational performance, competition, regulatory matters, and general economic conditions. Readers should not place undue reliance on these statements, which speak only as of the date made.

General Disclaimer:

InvestorsTape.com has been compensated for press and editorial coverage of NeOnc Technologies Holdings and further disclosure information is available here. This communication is provided for informational and journalistic purposes only and reflects the independent editorial views of InvestorsTape.com.

This editorial discusses investigational therapy and clinical-trial results and is not medical advice or a recommendation to buy or sell securities. This publication is protected speech under the First Amendment of the United States Constitution. Nothing herein constitutes an offer, solicitation, or recommendation to buy or sell any security, nor should it be construed as investment advice. Investing in securities involves risk, including the possible loss of principal. Readers are encouraged to conduct their own due diligence and consult with a qualified financial advisor before making any investment decision.


FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many NeOnc shares did CEO Amir Heshmatpour purchase in November 2026?

Heshmatpour purchased 70,000 common shares for approximately $230,510 on November 5 and 6. He bought 30,000 shares at a weighted average price of approximately $3.17 on November 5 and 40,000 shares at approximately $3.39 on November 6.

What did NeOnc’s NEO100 Phase 2a trial show?

The study met its primary endpoint, achieving six-month progression-free survival of 48.9% compared with a prespecified 20% benchmark (p=0.0047). NEO100 is an intranasal treatment candidate for recurrent IDH1-mutant high-grade glioma.

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