Intellia Therape Stock Price, News & Analysis

Intellia Therapeutics (NASDAQ:NTLA) will present at the 44th Annual J.P. Morgan Healthcare Conference in San Francisco on January 14, 2026 at 9:00 a.m. PT. A live webcast will be available on the company’s Events and Presentations page in the Investors & Media section at www.intelliatx.com. A replay of the webcast will be available on the website for approximately 30 days after the presentation.

Intellia Therapeutics (NASDAQ: NTLA) announced that on January 1, 2026 it awarded inducement grants to two new employees under its 2024 Inducement Plan.

The grants are time-based restricted stock units totaling 22,800 shares of common stock, with one-third vesting annually over three years and vesting subject to continued service. The 2024 Inducement Plan was adopted by the board in June 2024. The awards were approved by Intellia’s compensation committee as a material inducement to employment under Nasdaq Listing Rule 5635(c)(4).

Intellia Therapeutics (NASDAQ:NTLA) announced on December 1, 2025 that it granted inducement equity awards to three new employees under its 2024 Inducement Plan as material inducements to employment.

The awards are time-based restricted stock units totaling 12,600 shares, vesting in thirds on December 1, 2026, 2027, and 2028, and are subject to continued service through each vesting date. The grants were approved by the compensation committee and were made outside the company’s shareholder-approved equity incentive plans pursuant to Nasdaq Listing Rule 5635(c)(4).

Intellia Therapeutics (NASDAQ:NTLA) reported longer-term Phase 1 data for one-time IV nexiguran ziclumeran (nex-z) in ATTR amyloidosis with cardiomyopathy as of an Aug 23, 2025 data cut. Across 36 patients, a single dose produced rapid, deep and durable serum TTR reduction through three years (mean 87% reduction at 36 months; mean TTR 22.9 µg/mL).

At 24 months, markers showed stability or improvement (NT-proBNP 70%, hs-Troponin T 85%, 6MWT 69%, NYHA 81% stable/improved) and a post-hoc matched analysis showed lower all-cause mortality (3.9 vs 12.7 per 100 patient-years; HR 0.27; p=0.009). Safety findings were consistent with prior data (IRRs, transaminase elevations; liver enzymes ≤ Grade 2).

Intellia Therapeutics (NASDAQ: NTLA) presented pooled Phase 1/2 data for a one-time 50 mg IV dose of lonvoguran ziclumeran (lonvo-z) in hereditary angioedema (HAE) on Nov 8, 2025.

Key results: mean plasma kallikrein reduction of 89% at month 24; 31 of 32 patients (97%) were attack-free and long-term prophylaxis (LTP)-free at data cutoff (Aug 29, 2025); 24 of 32 (75%) were attack-free and LTP-free ≥7 months (up to 32 months). Of 11 Phase 2 patients dosed 50 mg, 10 were attack-free and LTP-free.

Safety: well-tolerated with up to three years follow-up, one resolved pulmonary embolism in a patient with risk factors, one transient Grade 2 AST elevation, and no new long-term risks identified. Phase 3 HAELO topline readout expected by mid-2026.

Intellia Therapeutics (NASDAQ:NTLA) reported Q3 2025 results and clinical updates on November 6, 2025. The company said the FDA placed a clinical hold on the MAGNITUDE and MAGNITUDE-2 Phase 3 trials of nex-z after rare Grade 4 liver transaminase elevations; more than 650 patients are enrolled in MAGNITUDE and 47 patients in MAGNITUDE-2. Intellia completed enrollment in the Phase 3 HAELO trial of lonvo-z and expects topline HAELO data by mid-2026, with a potential U.S. launch in 1H 2027. Cash, cash equivalents and marketable securities were $669.9M at September 30, 2025, and are expected to fund operations into mid-2027. Third-quarter net loss was $101.3M.

Intellia Therapeutics (NASDAQ:NTLA) announced a temporary pause of patient dosing and screening in its Phase 3 MAGNITUDE and MAGNITUDE-2 trials of nexiguran ziclumeran (nex-z) for ATTR-CM and ATTR-PN after an October 24, 2025 safety event.

The event involved a patient dosed on September 30, 2025 who developed Grade 4 liver transaminase elevations and increased total bilirubin, met protocol pausing criteria, was hospitalized and is receiving care. The company said it is consulting experts and engaging regulators. As of October 27, 2025, >650 ATTR-CM patients are enrolled in MAGNITUDE, 47 patients in MAGNITUDE-2, and an estimated >450 patients have been dosed with nex-z. A conference call and webcast were scheduled for 8:30 a.m. ET the same day.

Intellia Therapeutics (NASDAQ:NTLA) announced on October 1, 2025 inducement equity awards to six new employees under its 2024 Inducement Plan. The grants total 65,200 RSUs of common stock, vesting one‑third on Oct 1, 2026, 2027 and 2028, subject to continued service. The awards were granted outside Intellia’s stockholder‑approved plans and were approved by the compensation committee as a material inducement to employment in accordance with Nasdaq Listing Rule 5635(c)(4). The 2024 Inducement Plan was adopted by the board in June 2024. No cash amounts, price terms, or pro forma share dilution metrics were included in the release.

Intellia Therapeutics (NASDAQ:NTLA) has reported promising long-term Phase 1 data for nexiguran ziclumeran (nex-z) in treating hereditary ATTR amyloidosis with polyneuropathy. The single-dose treatment demonstrated sustained TTR reductions of at least 90% through three years, with significant clinical improvements.

Key findings include: 92% mean serum TTR reduction at 24 months in patients receiving ≥0.3 mg/kg doses (n=33), and 90% reduction at 36 months (n=12). Among 18 patients evaluated at 24 months, 72% showed clinically meaningful improvements in mNIS+7 scores. The treatment was generally well-tolerated, with only mild to moderate infusion-related reactions reported.

The company's Phase 3 MAGNITUDE-2 trial is progressing rapidly, with enrollment completion expected in H1 2026 and a potential BLA submission targeted for 2028.