Nextcure Stock Price, News & Analysis

NextCure, Inc. (Nasdaq: NXTC), a clinical-stage biopharmaceutical company, announced its participation in the Society for Immunotherapy of Cancer (SITC) annual meeting from November 8-12, 2022. The company will present data from its Phase 1 clinical study of NC762 and an overview of its NC410 combination study. NC762 targets B7-H4 to inhibit tumor growth, while NC410 blocks immune suppression mediated by LAIR-1. The presentations aim to showcase advancements in NextCure’s immunomedicines aimed at treating cancer.

NextCure, Inc. (NASDAQ: NXTC), a clinical-stage biopharmaceutical company, has initiated a Phase 1b/2 clinical trial for NC410 in combination with Merck's KEYTRUDA® in patients with immune checkpoint refractory or naïve solid tumors. The study aims to explore NC410's potential in treating colorectal, esophageal, endometrial, and head and neck cancers. Key points include: NextCure sponsoring the trial, a supply agreement with Merck, and expected initial data release in mid-2023. NC410 aims to block immune suppression mediated by LAIR-1.

NextCure, Inc. (Nasdaq: NXTC), a clinical-stage biopharmaceutical company, announced its presentation at the Ladenburg Thalmann Healthcare Conference in New York City on September 29 at 10 am ET. The event will include a live audio webcast available on the company’s website, with a replay accessible for 30 days post-event. NextCure focuses on developing first-in-class immunomedicines for cancer and immune-related diseases, utilizing its FIND-IO™ platform to identify novel treatment targets. The company aims to help patients unresponsive to existing therapies.

NextCure, Inc. (Nasdaq: NXTC) announced its Q2 2022 financial results, reporting cash reserves of $185.5 million, expected to fund operations through Q1 2024. The company is on track for updates from three clinical programs (NC318, NC410, and NC762) in H2 2022, along with an IND filing for NC525. Total cash, cash equivalents, and marketable securities decreased from $219.6 million at year-end 2021, driven by operational costs. Q2 R&D expenses rose to $12.8 million from $11.9 million last year, while general and administrative expenses fell to $5.3 million from $6.0 million.

NextCure (NASDAQ: NXTC) has published a paper detailing the development of an immunohistochemical assay for Siglec-15, a protein implicated in cancer's immunosuppressive environment. This research, conducted with Yale School of Medicine, presents data supporting the targeting of Siglec-15 in therapeutic candidates like NC318. The study shows high S15 expression in non-small cell lung cancer (NSCLC), indicating a potential pathway for future clinical trials. The assay's validation and scoring system hold promise for advancing patient selection in ongoing trials.

NextCure (NASDAQ: NXTC) presented promising data on NC410 at the 2022 ECM Pharmacology Congress in Copenhagen, showcasing its ability to remodel tumor extracellular matrix (ECM), enhance immune cell infiltration, and reduce tumor growth in humanized mouse models. This first-in-class immunomedicine targets LAIR-1, overcoming barriers to immunotherapy. Highlights include NC410's binding to collagen-rich areas and synergistic effects with PD-L1 targeting. Currently in a Phase 1/2 study for advanced solid tumors, NextCure anticipates updates in late 2022.

NextCure, Inc. (Nasdaq: NXTC) announced research findings on NC410, an immunomedicine that blocks neutrophil-mediated T cell suppression in the tumor microenvironment (TME). Presented at the 24th TRCCC Annual Meeting, these findings highlight NC410's potential to enhance T cell responsiveness in ovarian cancer. The research suggests that LAIR-1 engagement by NC410 could play a crucial role in overcoming immune suppression. Dr. Brahm Segal was appointed to NextCure's Scientific Advisory Board, indicating a strategic partnership for advancing NC410's development.

NextCure, a clinical-stage biopharmaceutical company focused on developing innovative immunomedicines for cancer and immune-related diseases, will participate in a fireside chat at the JMP Securities Life Sciences Conference on June 15, 2022, at 2 PM ET. The session will be available via live audio webcast on NextCure's website, with a replay accessible for 30 days post-event. NextCure utilizes its proprietary FIND-IO™ platform to discover new therapeutic targets for patients who do not respond to existing cancer therapies.

NextCure (NASDAQ: NXTC) reported its first quarter 2022 financial results, revealing a cash position of $201.3 million expected to fund operations into Q1 2024. The company is advancing its pipeline with updates anticipated for NC318, NC410, and NC762 in the second half of 2022, alongside an IND filing for NC525. However, the company faced a net loss of $20.6 million, increased R&D expenses of $15.0 million, and a decrease in cash from $219.6 million at the end of 2021.