Oculis to Present a Late-Breaking Abstract at the American Academy of Ophthalmology 2023 Annual Meeting on the Positive Stage 1 Results from Phase 3 DIAMOND Trial for Diabetic Macular Edema

Rhea-AI Summary

Oculis Holding AG announced positive results from Stage 1 of its Phase 3 DIAMOND trial of OCS-01 in patients with diabetic macular edema (DME). The results will be presented at the American Academy of Ophthalmology (AAO) 2023 Annual Meeting. OCS-01 is the first investigational eye drop for both front and back of the eye indications, with positive results in previous trials.

ZUG, Switzerland and BOSTON, Nov. 01, 2023 (GLOBE NEWSWIRE) -- Oculis Holding AG (Nasdaq: OCS) (“Oculis” or the “Company”), a global biopharmaceutical company purposefully driven to save sight and improve eye care, today announced that the positive results from Stage 1 of its Phase 3 DIAMOND trial of OCS-01 in patients with diabetic macular edema (DME), will be presented as a late-breaking abstract at the American Academy of Ophthalmology (AAO) 2023 Annual Meeting, taking place Friday, November 3, 2023 through Monday, November 6, 2023 in San Francisco, California.

AAO 2023
Session:	Late Breaking Developments, Part I – Retina Subspecialty Day
Presenter:	Hani Salehi-Had, M.D.
Title:	A 12-week Phase 2/3 Double-masked, Randomized, Multicenter Study of OCS-01 Eye Drops in Diabetic Macular Edema (DME)
Presentation time:	Friday, November 3, 2023 at 3:58 pm PDT
Location:	Moscone Center – West Building - 3004

OCS-01 is Oculis’ lead product candidate and the first investigational eye drop for both front and back of the eye indications, with positive results in Stage 1 of the Phase 3 DIAMOND trial for DME announced in May 2023, and positive Phase 3 OPTIMIZE trial results for inflammation and pain following cataract surgery announced in August 2023. Furthermore, the investigator-initiated LEOPARD study evaluating OCS-01 for the treatment of cystoid macular edema (CME) enrolled its first patient in August 2023.

Leveraging Oculis’ proprietary OPTIREACH® technology, OCS-01 is a novel, high concentration (15 mg/ml), topical formulation of dexamethasone. It is developed to reach the retina via an eye drop, a route of administration that is differentiated from currently available therapies, that are all invasive such as ocular implants or intravitreal injections to deliver the medication to the retina. If approved, OCS-01 has the potential to become the first topical preservative-free eye drop for the treatment of DME, the leading cause of vision loss and legal blindness in patients with diabetes.

About Oculis

Oculis (Nasdaq: OCS) is a global biopharmaceutical company purposefully driven to save sight and improve eye care. Oculis’ highly differentiated clinical-stage pipeline comprises multiple innovative product candidates in development for eye diseases of high unmet need. It includes OCS-01 eye drops, a topical candidate in Phase 3 development for diabetic macular edema (DME) and inflammation and pain following ocular surgery; OCS-02 eye drops, a topical biologic candidate in Phase 2 development for dry eye disease (DED) and uveitis; and OCS-05, a disease modifying candidate for acute optic neuritis (AON) and other neuro-ophthalmic disorders, such as glaucoma, diabetic retinopathy, geographic atrophy, and neurotrophic keratitis. The first in-patient, proof-of-concept trial with OCS-05 is currently ongoing in France. Headquartered in Switzerland and with operations in the US, Oculis’ goal is to deliver life-changing eye treatments to patients worldwide. The Company is led by an experienced management team with a successful track record in the pharmaceutical industry, supported by leading international healthcare investors.

For more information, please visit: www.oculis.com

Oculis Contacts

Mrs. Sylvia Cheung, CFO
sylvia.cheung@oculis.com

Investor & Media Relations

LifeSci Advisors
Corey Davis, Ph.D.
cdavis@lifesciadvisors.com
1-212-915-2577

 

FAQ

What is the company behind the Phase 3 DIAMOND trial of OCS-01?

The company behind the trial is Oculis Holding AG.

What is the purpose of the Phase 3 DIAMOND trial?

The purpose of the trial is to evaluate the efficacy of OCS-01 in patients with diabetic macular edema (DME).

What are the positive results from Stage 1 of the Phase 3 DIAMOND trial?

The positive results have not been specified in the press release.

Where will the results be presented?

The results will be presented at the American Academy of Ophthalmology (AAO) 2023 Annual Meeting in San Francisco, California.

What is OCS-01?

OCS-01 is an investigational eye drop developed by Oculis Holding AG.

What is the potential of OCS-01?

If approved, OCS-01 could become the first topical preservative-free eye drop for the treatment of diabetic macular edema (DME).