Oculis Holding Stock Price, News & Analysis

Oculis Holding AG (Nasdaq: OCS; XICE: OCS) has issued 2,500,000 new registered ordinary shares with a nominal value of CHF 0.01 each from its existing capital band. These shares are currently recorded as treasury shares. The company's total registered shares now stand at 48,943,700, with approximately 43 million shares outstanding. Following this issuance, treasury shares represent 7.2% of the company's registered shares.

The new shares were issued in connection with an at-the-market (ATM) offering program established through a sales agreement with Leerink Partners on May 8, 2024. Under this program, Oculis may offer and sell ordinary shares worth up to $100 million through Leerink Partners as its sales agent. The newly issued shares have not been sold under the ATM program and are being held in reserve as treasury shares.

In a brief announcement dated January 21, 2025, Oculis, based in Zug, Switzerland, has disclosed a notification regarding major changes in voting rights. The changes involve Íslandsbanki, though specific details about the nature and extent of these changes were not provided in the announcement.

On January 20, 2025, Oculis announced the publication of a Notification of Major Changes in Voting Rights in Zug, Switzerland. The notification specifically relates to changes involving Íslandsbanki. No further details about the nature or extent of the voting rights changes were provided in the announcement.

Oculis announced positive topline results from its Phase 2 ACUITY trial for OCS-05, a potential first-in-class neuroprotective therapy for acute optic neuritis. The trial met its primary safety endpoint and achieved statistical significance on key efficacy endpoints.

The randomized, double-blind study evaluated 33 patients receiving OCS-05 (2mg/kg/day or 3mg/kg/day) administered intravenously for five days. Key results include:

• 43% improvement in GCIPL thickness at 3 months for OCS-05 (3mg/kg/day)
• 28-30% improvement in RNFL thickness at 3-6 months
• Approximately 18 letters improvement in visual function at 3 months

The treatment showed a favorable safety profile with no serious adverse events or discontinuations. The FDA has granted orphan drug designation and cleared the IND application, enabling U.S. clinical development. The company reports approximately $105-110 million in cash and equivalents.

Oculis (Nasdaq: OCS) announced positive topline results from its Phase 2 ACUITY trial for OCS-05, a neuroprotective therapy candidate for acute optic neuritis. The trial met its primary safety endpoint and achieved statistical significance on key efficacy endpoints. The study demonstrated a 43% improvement in GCIPL thickness and 28% improvement in RNFL thickness with OCS-05 (3mg/kg/day) plus steroid versus placebo at 3 months.

The trial involved 36 randomized patients, with 33 included in the modified intent-to-treat analysis. Visual function improvements showed approximately 18 letters improvement at month 3 and 15 letters at month 6. No drug-related serious adverse events were reported, with headache and acne (10.5% each) being the most common side effects.

OCS-05 has received orphan drug designation from both FDA and EMA, and its IND application has been cleared by the FDA. The company reports approximately $105-110 million in cash and equivalents entering 2025.

On January 4, 2025, Oculis Holding AG announced a significant change in its voting rights structure. The change occurred due to Brunnur vaxtarsjóður slhf distributing its shares in Oculis to its own shareholders. This redistribution of shares represents a major shift in the company's ownership structure.

Oculis has published notifications regarding transactions by individuals with managerial responsibilities. The notifications pertain to the vesting and settlement of Restricted Stock Units (RSUs) previously granted to the company's directors.

The attached documents detail the transactions for two directors:

• Anthony Rosenberg - December 2024
• Arshad Khanani - December 2024

Oculis has announced the vesting of earnout shares and the removal of restrictions on these ordinary shares.

The notifications involve key managerial figures, including Anthony Rosenberg, Riad Sherif, Sylvia Cheung, and Pall Johanesson. Each notification details specific transactions related to these individuals.

The vesting of these shares signifies a notable event for the company and its stakeholders, potentially impacting stock performance due to changes in share availability and managerial ownership.

Oculis has announced a one-time equity incentive award issued to a director for his independent services as a consultant. The notification of this managerial transaction involves Arshad Khanani and was published in November 2024.