Welcome to our dedicated page for Oncternal Therapeutics news (Ticker: ONCT), a resource for investors and traders seeking the latest updates and insights on Oncternal Therapeutics stock.
The ONCT news page on Stock Titan aggregates press releases and other coverage related to Oncternal Therapeutics, Inc., a company that has been described in its own communications as a clinical-stage biopharmaceutical developer of oncology therapies. These news items trace both the evolution of its investigational pipeline and its later strategic decisions, giving investors and researchers a consolidated view of the company’s trajectory.
Earlier news focuses on clinical and operational updates for programs such as ONCT-534, an investigational dual-action androgen receptor inhibitor evaluated in metastatic castration-resistant prostate cancer, and ONCT-808, an autologous CAR T cell therapy targeting ROR1 in relapsed or refractory aggressive B-cell lymphoma. Releases detail dose-escalation cohorts, safety and tolerability observations, interim efficacy signals based on measures like prostate-specific antigen levels, and protocol amendments in ongoing Phase 1/2 studies.
Other articles describe the broader pipeline, including zilovertamab, a monoclonal antibody targeting ROR1 studied in combination with ibrutinib and in investigator-initiated trials, and ONCT-216, a small-molecule inhibitor of ETS family oncoproteins with regulatory designations for Ewing sarcoma. These pieces provide context on the scientific rationale and clinical settings in which the agents have been tested.
More recent news documents a shift in corporate direction. A September 2024 press release announces the termination of clinical studies for ONCT-534 and ONCT-808, the discontinuation of product development activities and the exploration of strategic alternatives. A July 2025 release reports the sale of the zilovertamab and ONCT-808 programs to Ho’ola Therapeutics, Inc. and states that a new executive will oversee the winddown of Oncternal’s operations. Together, these items form a historical record of how the ONCT story moved from active clinical development toward asset sales and an operational wind-down.
Users interested in ONCT news can review this stream to understand the company’s investigational programs, clinical milestones, strategic reviews and the subsequent wind-down steps described by Oncternal in its own announcements.
Oncternal Therapeutics, Inc. (Nasdaq: ONCT) announced the presentation of two abstracts at the ASCO 2021 Annual Meeting, scheduled for June 4-8, 2021. The oral presentation, titled TK216 for relapsed/refractory Ewing sarcoma: Interim phase 1/2 results, will take place on June 4, 2021, while the poster presentation, Phase 1/2 study of cirmtuzumab and ibrutinib in mantle cell lymphoma or chronic lymphocytic leukemia, is set for June 7, 2021. Both investigational therapies target cancer with unmet medical needs and have received various FDA designations, emphasizing their potential in oncology.
Oncternal Therapeutics, Inc. (Nasdaq: ONCT) has appointed Chase Leavitt as General Counsel, effective April 12, 2021. Leavitt brings extensive legal experience from leading biotech and technology firms, which is expected to bolster Oncternal's growth trajectory.
Leavitt's responsibilities will include navigating legal compliance and governance as the company develops its ROR1-targeting therapies and other oncology products. He received a B.S. and J.D. from the University of Southern California, adding valuable expertise to Oncternal's leadership team.
Oncternal Therapeutics, Inc. (Nasdaq: ONCT) announced promising interim results from a Phase 1b trial of cirmtuzumab combined with paclitaxel in HER2-negative breast cancer, showing a 57% partial response rate among evaluable patients. In preclinical studies, cirmtuzumab demonstrated single-agent efficacy and enhanced effects with standard chemotherapies against high-grade serous ovarian and endometrial cancers. Additionally, investigational selective androgen receptor degraders showed inhibition of tumor growth in androgen receptor-positive triple-negative breast cancer models. The company continues to advance its clinical programs.
Oncternal Therapeutics, Inc. (Nasdaq: ONCT) announced the granting of an inducement award to new Senior VP of Human Resources, Anita Wiseth, on March 18, 2021. The award includes options for 90,000 shares at an exercise price of $8.36, vesting over four years. This grant, part of Oncternal’s 2021 Employment Inducement Incentive Award Plan, was approved by an independent compensation committee in compliance with Nasdaq regulations. The company focuses on developing novel oncology therapies targeting significant unmet medical needs.
Oncternal Therapeutics (Nasdaq: ONCT) reported encouraging interim results for cirmtuzumab combined with ibrutinib in its ongoing Phase 1/2 study for mantle cell lymphoma (MCL), showing a 47% complete response (CR) rate versus a historical 20% CR. The company is advancing ROR1-targeting CAR-T therapies and has two durable responses reported in Ewing sarcoma patients treated with TK216. Financially, Oncternal raised $125 million in 2020 to support its pipeline, with a net loss of $17.2 million for the year and $116.7 million cash on hand as of December 31, 2020.
Oncternal Therapeutics, Inc. (Nasdaq: ONCT) will report its fourth quarter and full year 2020 financial results on March 11, 2021, post-market. A webcast will follow at 2:00 p.m. PT for management to discuss the results and provide a business update. Oncternal is focused on developing novel oncology therapies addressing unmet medical needs, with ongoing clinical studies for cirmtuzumab and TK216. The company's primary aim is to tap into promising biological pathways involved in cancer progression.
Oncternal Therapeutics (Nasdaq: ONCT) will participate in two significant virtual conferences in March 2021. The first is the H.C. Wainwright Global Life Sciences Conference on March 9, starting at 7:00 AM ET, with James Breitmeyer presenting. The second event is the Oppenheimer 31st Annual Healthcare Conference on March 16, at 4:30 PM ET, also featuring Breitmeyer. Both presentations will be available for streaming, and links can be found on Oncternal's investor website. The company focuses on developing innovative oncology therapies.
Oncternal Therapeutics, Inc. (Nasdaq: ONCT) announced the granting of an inducement award to Christy Stolzer, its new Associate Director of Drug Safety, on February 22, 2021. The award includes options to purchase 60,000 shares of common stock at an exercise price of $7.20 per share, vesting over four years. This grant adheres to Oncternal's 2021 Employment Inducement Incentive Award Plan, aimed at attracting new employees. The options were approved by the independent compensation committee as required by Nasdaq regulations.
Oncternal Therapeutics appointed Dr. Rosemary Mazanet to its Board of Directors, effective January 27, 2021. She brings extensive oncology drug development experience, having led initiatives at Amgen and serving in leadership roles in various biopharma companies. Dr. Mazanet's expertise is expected to enhance Oncternal's ongoing projects, including cirmtuzumab and ROR1 CAR-T programs. Oncternal focuses on innovative oncology therapies targeting unmet medical needs, with clinical trials underway for its candidates.
Oncternal Therapeutics, Inc. (Nasdaq: ONCT) announced a partnership with Lentigen Technology to manufacture lentiviral vectors for its ROR1-targeting CAR-T cell therapy program. The agreement aims to accelerate the development of this innovative cancer treatment, with GMP manufacturing reserved for 2021. Oncternal's President noted the significance of ROR1 as a target in oncology, with plans to achieve first-in-human dosing in the latter half of 2021. This collaboration underscores Oncternal's commitment to advancing cancer therapies with high unmet medical needs.