Welcome to our dedicated page for Oric Pharmaceuticals news (Ticker: ORIC), a resource for investors and traders seeking the latest updates and insights on Oric Pharmaceuticals stock.
News and updates on ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC) focus on its progress as a clinical stage oncology company developing therapies that address mechanisms of therapeutic resistance in cancer. ORIC regularly reports clinical data, operational milestones, and financial updates that are relevant to investors and observers following the ORIC stock and its development programs.
Recent news highlights include Phase 1b data for ORIC-944 (also referred to as rinzimetostat) in metastatic castration-resistant prostate cancer, where the company has discussed PSA responses, circulating tumor DNA reductions, and a safety profile described as compatible with long-term dosing when combined with androgen receptor inhibitors. ORIC also provides updates on preclinical findings for ORIC-944 in castration-sensitive prostate cancer models and KRAS G12C-mutant NSCLC and colorectal cancer models.
For enozertinib (ORIC-114), ORIC’s news flow includes late-breaking oral and poster presentations at major scientific meetings such as the ESMO Asia Congress. The company reports systemic and CNS activity in non-small cell lung cancer patients with EGFR exon 20, EGFR atypical (including PACC), and HER2 exon 20 mutations, including in patients with active brain metastases. These articles often detail objective response rates, disease control rates, intracranial responses, and safety observations from Phase 1b cohorts.
Corporate news items cover participation in healthcare conferences, strategic pipeline prioritization to focus on ORIC-944 and enozertinib, leadership appointments such as the creation of a Chief Technical Officer role, and capital raises via private placements and at-the-market programs. Financial press releases summarize quarterly results, research and development spending, and the company’s cash and investment position.
This news page aggregates ORIC’s press releases and related disclosures so readers can follow clinical trial readouts, program updates, corporate developments, and other material events affecting ORIC Pharmaceuticals and the ORIC ticker over time.
ORIC (NASDAQ: ORIC) reported 2025 operational highlights and 2026 milestones, emphasizing clinical progress for rinzimetostat (ORIC-944) in mCRPC and enozertinib in NSCLC. Key clinical metrics: rinzimetostat showed PSA50 in 55% (confirmed 40%), PSA90 in 20%, and ctDNA >50% reduction in 76% with 59% clearance. Enozertinib showed strong systemic activity (1L ORR 67% in EGFR exon 20; 80% in EGFR PACC) and 100% intracranial ORR in measurable CNS disease. Company selected provisional RP2Ds, plans a Phase 3 start for rinzimetostat in 1H 2026, and expects multiple 2026 readouts. Financials: raised $244M in 2025; cash and investments of $413M expected to fund operations into 2H 2028.
ORIC Pharmaceuticals (Nasdaq: ORIC) announced that Jacob M. Chacko, M.D., chief executive officer, will present a company overview at the 44th Annual J.P. Morgan Healthcare Conference on Tuesday, January 13, 2026 at 9:45 a.m. PT.
A live webcast will be available via the company’s investor website at www.oricpharma.com, and a replay will be accessible for 90 days after the event.
ORIC (Nasdaq: ORIC) reported Phase 1b data for enozertinib (ORIC-114) in EGFR exon 20 NSCLC at ESMO Asia Congress 2025 on Dec 6, 2025. Key efficacy: 1L best ORR 67% (60% confirmed in initial cohort) and 100% intracranial confirmed ORR by BICR-RANO; 2L confirmed ORR 45% in the 80 mg cohort. Safety: mostly Grade 1–2 TRAEs, low discontinuation (2 in 1L, 3 in 2L), more dose reductions at 120 mg. Follow-up median ~30–33 weeks. Company selected 80 mg QD for potential Phase 3; enrollment continues with next update expected mid-2026. Conference call and webcast held Dec 6, 2025 at 8:00 pm ET.
ORIC Pharmaceuticals (Nasdaq:ORIC) announced inducement equity grants on December 1, 2025 to three newly hired non-executive employees who began in November 2025. The company granted 69,200 non-qualified stock options and 11,400 restricted stock units under the 2022 Inducement Equity Incentive Plan, subject to continued service through vesting dates.
The stock options use an exercise price equal to ORIC’s closing common stock price on the grant date. Options vest 25% after one year, then monthly at 1/36th of the remainder; RSUs vest one-third on each of the first three anniversaries. Grants were approved by the Compensation Committee per Nasdaq Rule 5635(c)(4) as material inducements to employment.
ORIC (NASDAQ: ORIC) reported Phase 1b data for oral enozertinib in previously treated NSCLC patients with HER2 exon 20 mutations presented at ESMO Asia Congress 2025. As of Aug 29, 2025, 49 patients were dosed (26 at 80 mg QD; 23 at 120 mg QD), with 47% having baseline brain metastases.
Key results in the 80 mg cohort: 35% ORR (26% confirmed ORR) and 100% disease control rate; manageable safety with mostly Grade 1–2 TRAEs and only 2 discontinuations. Median follow-up was 50 weeks; 32% of patients remained on treatment. Enrollment in HER2 exon 20 completed and no further development planned for that population; 80 mg QD selected for potential Phase 3 based on related cohorts.
ORIC (Nasdaq: ORIC) reported Phase 1b data for enozertinib (ORIC-114) at ESMO Asia Congress 2025 showing strong systemic and CNS activity in NSCLC with EGFR atypical and PACC mutations. In previously treated patients with PACC mutations (22 efficacy-evaluable), enozertinib achieved a 36% confirmed ORR and 91% DCR with median follow-up >32 weeks. In preliminary 1L PACC patients (10 efficacy-evaluable at 80 mg QD) the drug showed 80% ORR and 100% intracranial ORR in measurable CNS disease. Safety was manageable, with no TRAE-related discontinuations; 80 mg QD selected as the potential Phase 3 dose and next update expected mid-2026.
ORIC Pharmaceuticals (Nasdaq: ORIC) announced two late-breaking oral presentations of Phase 1b data for enozertinib (ORIC-114) at the ESMO Asia Congress 2025 in Singapore (December 5–7, 2025).
The mini-oral (LBA15) on Dec 5, 2025 at 11:38–11:43 a.m. SGT covers previously treated EGFR atypical mutant NSCLC with randomized dose optimization and CNS activity. The proffered paper oral (LBA13) on Dec 6, 2025 at 10:02–10:12 a.m. SGT covers EGFR exon 20 mutant NSCLC in previously treated and treatment-naïve patients. ORIC will host a conference call and webcast on Dec 6, 2025 at 8:00 p.m. ET, with a replay available for 90 days.
ORIC (Nasdaq: ORIC) will present clinical data for enozertinib (ORIC-114) in previously treated patients with HER2 exon 20 mutant NSCLC at the ESMO Asia Congress 2025 in Singapore (December 5–7, 2025).
The poster (Presentation 981P) is scheduled for Friday, December 5, 2025, 5:15–6:15 p.m. SGT in a poster display session.
ORIC will host a related conference call and live webcast on Saturday, December 6, 2025 at 8:00 p.m. ET; live Q&A will require pre‑registration and the webcast replay will be available via ORIC’s investor website for 90 days.
ORIC Pharmaceuticals (Nasdaq: ORIC) said management will participate in a fireside chat at the 8th Annual Evercore Healthcare Conference on Wednesday, December 3, 2025 at 11:15 a.m. ET and will hold one-on-one investor meetings.
The live webcast will be available via the company’s investor website and a replay will be accessible for 90 days after the event.
ORIC (Nasdaq: ORIC) reported Q3 2025 results and clinical updates on Nov 13, 2025. The company completed dose exploration for ORIC-944 Phase 1b and selected provisional RP2Ds (400/600 mg with darolutamide; 600/800/1,200 mg with apalutamide). In 20 mCRPC patients, ORIC reported PSA50 55% (PSA90 20%) and ctDNA reductions: >50% in 76% and ctDNA clearance 59%. Safety profile compatible with long-term dosing; one Grade 3 TRAE, no Grade 4/5 attributed. Enozertinib INN approved; multiple Phase 1b cohorts enrolling. Corporate: CTO appointment and $413.0M cash/investments expected to fund operations into 2H 2028.
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