Dr. Vuong Trieu, Developer of Novel Oncology and Immunotherapy Assets, Leads Oncotelic Therapeutics’ Commitment to Innovation, Life-Saving Therapies

Rhea-AI Summary

Oncotelic Therapeutics (OTCQB: OTLC) highlighted the contributions of Chairman and CEO Dr. Vuong Trieu and provided an update on its clinical pipeline. Dr. Trieu, a renowned industry pioneer, has an extensive portfolio of over 500 filed patents and 75 issued patents covering various therapeutic areas.

His notable achievements include co-inventing Abraxane® (acquired for $2.9 billion) and developing Cynviloq™ (sold for $1.3 billion). The company's pipeline includes six key programs: OT-101 (Phase 3 for pancreatic cancer), OXi4503 (Phase 2 in AML/MDS), CA4P/Fosbretabulin, AL-101 (Phase 2 for Parkinson's), AL-102 (discovery stage), and pediatric rare disease programs.

Positive

• Extensive intellectual property portfolio with over 500 filed patents and 75 issued patents
• Strong track record of successful drug development and monetization (Abraxane® $2.9B, Cynviloq™ $1.3B)
• Diverse clinical pipeline with six programs across different development stages
• Focus on high-value areas including oncology, rare diseases, and neurology

Negative

• Multiple early-stage programs requiring significant development funding
• Trading on OTCQB market rather than major exchange
• High dependency on single executive (Dr. Trieu) for innovation and leadership

Dr. Trieu’s prolific career includes multibillion-dollar drug discoveries targeting cancers of the breast, pancreas and non-small cell lung cancer, among others

Oncotelic’s robust portfolio and clinical pipeline is supported by the innovations and intellectual property generated by Dr. Trieu

AGOURA HILLS, Calif., Sept. 04, 2025 (GLOBE NEWSWIRE) -- via IBN -- Oncotelic Therapeutics, Inc. (OTCQB: OTLC) (“OTLC” or the “Company”), a clinical stage biopharmaceutical company developing transformative oncology and immunotherapy treatments, today shares an update on its clinical pipeline and highlights the invaluable contributions of its Chairman and CEO Dr. Vuong Trieu, who is recognized worldwide for his extraordinary intellectual property portfolio and impact on the biopharma industry.

Dr. Trieu is a prolific industry pioneer with over 500 filed patents and 75 issued patents covering biologics, small molecules, nanoparticles, diagnostics. Over his career he has invented, co-invented, and developed multiple novel therapeutics that have advanced to U.S. Food and Drug Administration (FDA) approval or late-stage development. Most notably, Dr. Trieu co-invented and developed Abraxane^® (nab-paclitaxel), acquired by Celgene in 2010 as part of a $2.9 billion transaction. He later developed and sold Cynviloq^™ (nanoparticle paclitaxel) to NantPharma in 2015 in a deal valued at $1.3 billion. His career contributions extend across oncology, cardiovascular, reproductive, infectious-disease, neuro-critical-care, aging, and rare diseases, with a consistent focus on delivering first-in-class therapeutics to address high unmet medical needs.

OTLC Pipeline Overview

• OT-101 (TGF-β inhibitor): Phase 3 for pancreatic cancer, with additional applications in ARDS/COVID-19

• OXi4503 (vascular disrupting agent): Phase 2 in AML/MDS; advancing toward pivotal phase 3 design

• CA4P / Fosbretabulin: Late-stage oncology asset currently under repositioning

• AL-101 (intranasal apomorphine): Phase 2 for Parkinson’s disease and Sexual Dysfunctions

• AL-102 (oligonucleotide antisense via intrathecal injection): Discovery stage for Alzheimer’s disease

• Pediatric Rare Disease Programs: Targeting orphan indications with the potential to generate Priority Review Vouchers (PRVs)

Dr. Trieu’s innovations form the cornerstone of OTLC’s intellectual property portfolio, reinforcing the Company’s strategy of building value through differentiated biotechnology assets with strong competitive barriers.

“Our strength lies not only in OTLC’s clinical pipeline but also in the breadth of intellectual property generated over my career, converting deep tumour-microenvironment biology into globally protected, clinic-ready technologies that redefine how drugs are delivered, monitored, and personalised,” said Dr. Trieu. “We remain committed to transforming these innovations into life-saving therapies for patients and long-term value for shareholders.”

About Oncotelic Therapeutics

Oncotelic Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the development of oncology and immunotherapy products. The Company’s mission is to address high-unmet-need cancers and rare pediatric indications with innovative, late-stage therapeutic candidates.

In addition to its directly owned and developed drug pipeline, Oncotelic benefits from the robust portfolio of inventions created by its CEO, Dr. Vuong Trieu, who has filed over 150 patent applications and holds 39 issued U.S. patents. Beyond its internal programs, the Company also licenses and co-develops select drug candidates through joint ventures. Currently, Oncotelic owns 45% of GMP Bio, a joint venture under Dr. Trieu’s leadership and guidance, which is advancing its own pipeline of drug candidates that further complement and strengthen Oncotelic’s strategic position in oncology and rare disease therapeutics.

For more information, please visit: www.oncotelic.com

Oncotelic Cautionary Note on Forward‑Looking Statements

This press release contains forward‑looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements in this release other than statements of historical fact are forward‑looking and are based on current expectations, estimates, and projections about our business and future plans. In some cases, you can identify forward‑looking statements by terms such as “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “project,” “forecast,” “potential,” “continue,” and similar expressions (including the negative of such terms).

Forward‑looking statements in this release include, without limitation: our plans, timelines, and priorities for the OT‑101 program in PDAC and other indications; potential biomarker‑driven development strategies; the advancement, scope, timing, and results of current or future preclinical and clinical studies; regulatory interactions and potential approvals; development or commercialization of any product candidates within the Oncotelic/GMP Bio/Sapu ecosystem; the utility of our PDAOAI platform; future financings, strategic transactions, and/or public offerings involving our joint ventures or affiliates; and other statements that are not historical facts. Actual results may differ materially from those indicated by such forward‑looking statements as a result of various important factors, including, but not limited to: the inherent uncertainties of drug discovery and development; our ability to enroll patients and complete studies on expected timelines; whether preclinical or early clinical findings (including biomarker associations) will be replicated in larger, controlled trials; regulatory developments in the United States and other jurisdictions; competitive developments; our ability to obtain or maintain intellectual property protection; our liquidity and access to capital; the performance of collaborators, suppliers, and manufacturers; and other risks described in our filings with the Securities and Exchange Commission (SEC), including the “Risk Factors” section of our most recent Form 10‑K and subsequent periodic reports.

Forward‑looking statements speak only as of the date of this press release, and we undertake no obligation to update or revise such statements, whether as a result of new information, future events, or otherwise, except as required by law.

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FAQ

What is Dr. Vuong Trieu's track record in drug development at Oncotelic Therapeutics (OTLC)?

Dr. Trieu has over 500 filed patents and 75 issued patents. He co-invented Abraxane® (acquired for $2.9B) and developed Cynviloq™ (sold for $1.3B), demonstrating successful track record in drug development and commercialization.

What are the main clinical programs in Oncotelic Therapeutics' (OTLC) pipeline?

OTLC's main programs include OT-101 (Phase 3 for pancreatic cancer), OXi4503 (Phase 2 in AML/MDS), CA4P/Fosbretabulin, AL-101 (Phase 2 for Parkinson's), AL-102 (discovery stage), and pediatric rare disease programs.

What is the most advanced drug candidate in Oncotelic Therapeutics' (OTLC) pipeline?

OT-101, a TGF-β inhibitor, is the most advanced candidate in Phase 3 clinical trials for pancreatic cancer, with additional applications in ARDS/COVID-19.

How many patents has Dr. Trieu generated for Oncotelic Therapeutics (OTLC)?

Dr. Trieu has generated an extensive intellectual property portfolio with over 500 filed patents and 75 issued patents covering biologics, small molecules, nanoparticles, and diagnostics.

What therapeutic areas does Oncotelic Therapeutics (OTLC) focus on?

OTLC focuses on multiple therapeutic areas including oncology, cardiovascular, reproductive, infectious-disease, neuro-critical-care, aging, and rare diseases, with emphasis on first-in-class therapeutics.