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Pacific Biosciences of California, Inc. reports developments in long-read sequencing systems and genomic-analysis workflows. The company designs, develops, and manufactures sequencing solutions, including HiFi long-read sequencing technology, for research applications such as human germline sequencing, plant and animal sciences, infectious disease and microbiology, oncology, rare disease research, metagenomics, and reproductive genetics.
Recurring PACB updates include quarterly financial results, Revio system adoption, chemistry and library-preparation workflows, partner integrations for bioinformatics and sample preparation, research consortia using HiFi whole genome data, and governance changes. Company releases also reflect its focus on long-read sequencing following the completed disposition of short-read sequencing assets.
PacBio (NASDAQ: PACB) announced participation in three upcoming investor conferences. The events include:
- Canaccord Genuity MedTech Forum on November 17, 2022, at 10:00 AM ET in New York.
- Evercore ISI 5th Annual HealthCONx Conference on November 29, 2022, at 4:20 PM ET (virtual).
- Piper Sandler 34th Annual Healthcare Conference on December 1, 2022, at 8:00 AM ET in New York.
Live webcasts will be available on the company's investor page, with replays for 30 days post-presentation.
PacBio (NASDAQ: PACB) reported Q3 2022 financial results with a revenue of $32.3 million, down 7% from $34.9 million year-over-year. Instrument revenue decreased to $11.4 million, while consumables revenue rose to $16.1 million. The net loss for the quarter was $77.0 million, a decline from a net income of $16.5 million in Q3 2021. Cash reserves fell to $834.3 million compared to $1,044.4 million at the end of 2021. The company launched new products, including Revio and Onso, expected to ship in 2023, and withdrew prior financial guidance.
PacBio (NASDAQ: PACB) has established a new Scientific Advisory Board (SAB)/b) to enhance its research and development efforts. The SAB will provide strategic guidance, critical feedback, and expertise in areas vital to advancing . Notable members include Euan Ashley, M.D., Ph.D., and Joseph Puglisi, Ph.D., both from Stanford University, and Jay Shendure, Ph.D., from the University of Washington. The board aims to support PacBio’s innovation in sequencing technologies while highlighting the importance of genomics in health.
PacBio announced the launch of its Revio long-read sequencing system, designed to significantly enhance throughput and affordability of HiFi sequencing. Revio allows sequencing of up to 1,300 human genomes annually at 30-fold coverage for under $1,000 per genome. The system features a new SMRT Cell design with three-fold higher density, NVIDIA GPUs for enhanced computing power, and reduced consumable requirements. With a list price of $779,000, PacBio aims to deliver Revio in early 2023, empowering large studies across human genetics and agricultural genomics.
PacBio (NASDAQ: PACB) announced the external beta testing of its Onso™ sequencing system, a revolutionary benchtop short-read DNA sequencing platform known for its accuracy. This system, leveraging PacBio's proprietary SBB technology, is expected to enhance capabilities in oncology and disease research. Orders for Onso are anticipated in Q1 2023, with shipments commencing in H1 2023. The platform is designed for various library preparations and is priced at $259,000. Beta testing will occur at three prestigious sites, enabling feedback for further development.
PacBio (NASDAQ: PACB) announced the withdrawal of its 2022 financial guidance due to upcoming product announcements. The company will discuss its third quarter financial results during a conference call on November 7, 2022, and will also hold its inaugural Investor Day on November 15, 2022. These events will feature presentations from the executive team and Q&A sessions. Investors are encouraged to listen live via PacBio's website.
PacBio (NASDAQ: PACB) launched the innovative Multiplexed Arrays Sequencing (MAS-Seq) kit, developed in collaboration with the Broad Institute and 10x Genomics. This kit facilitates cost-effective, long-read single-cell RNA sequencing, enhancing research capabilities, particularly in cancer and neurodegenerative diseases. The MAS-Seq kit aims to identify novel isoforms and mutations and will be accompanied by new SMRTLink software for data analysis. Orders are being accepted, with shipments starting in early November. A webinar to discuss the technology is scheduled for November 16, 2022.
PacBio (NASDAQ: PACB) and Twist Bioscience have launched a new portfolio of long-read sequencing panels, including a 50-gene pharmacogenomics panel and a 400-gene 'dark gene' panel. Designed for cost-effective high-throughput sequencing, these panels target medically significant genes related to various diseases. The collaboration aims to enhance research capabilities in genetics, facilitating the understanding of drug response and disease mechanisms. Additionally, the technology promises greater accuracy in sequencing challenging genomic regions.
PacBio (NASDAQ: PACB) has launched the Consortium for Long Read Sequencing (CoLoRS) aimed at creating a publicly accessible database of human genome datasets using long-read sequencing technology. This initiative will support researchers in identifying genetic variations, particularly in rare diseases, where many cases remain unexplained. Funded by the National Institutes of Health, CoLoRS will house data processed through standardized pipelines and will be available via the NHGRI's cloud-based platform. The database is expected to be populated by late 2022.
PacBio (NASDAQ: PACB) announced a new computational analysis method called Tandem Repeat Genotyping Tool (TRGT) for studying tandem repeats (TRs) in the human genome. This tool enables comprehensive profiling of TRs and their methylation status, aiding researchers in understanding their role in diseases like ALS and Fragile X syndrome. TRGT improves the analysis of genetic variations and can identify disease-causing TRs. The tool is available on GitHub alongside a companion visualization tool, enhancing usability for genomic research.