Panbela Therapeutics Inc Stock Price, News & Analysis

On November 28, 2022, Panbela Therapeutics (Nasdaq: PBLA) announced the enrollment of its first patients in Europe for the ASPIRE global clinical trial, aimed at treating metastatic pancreatic cancer with ivospemin, gemcitabine, and nab-Paclitaxel. Following recent regulatory approvals, the trial is expected to grow to approximately 95 sites worldwide by early to mid-2023. The company anticipates an interim analysis in early 2024, with promising clinical results showing median overall survival of 14.6 months in previous studies of ivospemin.

On November 10, 2022, Panbela Therapeutics, Inc. (Nasdaq: PBLA) reported its Q3 financial results, highlighting key milestones in its drug development pipeline. The Aspire Trial for metastatic pancreatic cancer saw its first patient enrolled, with regulatory approvals for sites in Spain, France, Italy, and Australia. The company completed a public offering, raising $6 million. However, Q3 net loss was $4.4 million, increasing from $2.1 million a year prior, with total cash at $0.9 million and current liabilities at $8 million. Panbela anticipates ongoing milestones to enhance shareholder value in 2023.

Panbela Therapeutics (Nasdaq: PBLA) will host a conference call on November 10, 2022, at 4:30 PM ET to discuss its third-quarter results for the period ending September 30, 2022. The company is focused on developing innovative therapeutics aimed at urgent medical needs, especially for conditions like familial adenomatous polyposis (FAP) and pancreatic cancer. Their lead candidates include SBP-101, which demonstrates promising survival rates in clinical trials, and Flynpovi, which has shown significant efficacy in preventing pre-cancerous growths.

Panbela Therapeutics (Nasdaq: PBLA) announced participation in the inaugural Roth Healthcare Opportunities Conference on October 6, 2022, in New York. The event aims to connect public healthcare companies with investors through presentations and one-on-one meetings. Panbela's pipeline targets critical conditions including familial adenomatous polyposis and pancreatic cancer. Lead assets include Ivospemin, demonstrating a median overall survival of 14.6 months in trials, and Flynpovi, showing over 90% prevention of pre-cancerous adenomas. For more details, visit www.panbela.com.

Panbela Therapeutics (PBLA) announced a public offering of 20,100,000 shares at $0.30 each, along with warrants for 30,150,000 shares. The offering, expected to close around October 4, 2022, will generate approximately $6 million in gross proceeds. Funds will support the clinical development of ivospemin (SBP-101) and eflornithine (CPP-1X), along with general corporate purposes. Roth Capital Partners leads the placement, with regulatory filings completed on September 29, 2022. The company's pipeline targets urgent medical needs, including various cancers.

Panbela Therapeutics (Nasdaq: PBLA) announced regulatory approval for trial sites in Spain, France, and Italy for their ASPIRE clinical trial. This global trial evaluates ivospemin combined with gemcitabine and nab-paclitaxel for treating metastatic pancreatic cancer. With 95 sites planned worldwide, site initiation will accelerate, with expectations for a significant number of global sites open by year-end. Interim analysis is anticipated in early 2024. Ivospemin has shown promising clinical results, including a median overall survival of 14.6 months in previous studies.

Panbela Therapeutics (Nasdaq: PBLA) announced a business update and financial results for Q2 2022. Key highlights include the enrollment of the first patient in the Aspire Trial, approval to expand global trials to Australia, and the acquisition of Cancer Prevention Pharmaceuticals (CPP). The combined entity targets a $5 billion market opportunity. Q2 financials show a net loss of $21.1 million, or $1.51 per share, with cash totaling $2.5 million. The company expects significant developments in its pipeline, including a fully funded Phase III trial beginning in early 2023.

Panbela Therapeutics, Inc. (Nasdaq: PBLA) has initiated the ASPIRE trial, a global clinical study evaluating SBP-101 combined with Gemcitabine and Nab-Paclitaxel for metastatic pancreatic ductal adenocarcinoma. The first patient has been enrolled in Australia, with over 90 additional sites expected to open by early 2023. An interim analysis is slated for early 2024, with a total sample size of 600 subjects. SBP-101 has shown promising results in prior studies, with a median overall survival of 14.6 months and an objective response rate of 48%, highlighting its potential against standard treatments.

Panbela Therapeutics (Nasdaq: PBLA) announced the approval from the Australian Human Research Ethics Committee to extend its ASPIRE trial to Australia, testing SBP-101 with Gemcitabine and Nab-Paclitaxel for metastatic pancreatic cancer. The trial aims at overall survival as its primary endpoint and will involve around 90 sites across 10 countries by early 2023. Patient screening has started, with interim analysis enrollment expected to finish in early 2024. The pipeline includes candidates for various cancers, with SBP-101 displaying promising efficacy in clinical studies.