STOCK TITAN

Phathom Pharmaceuticals Reports Fourth Quarter and Full Year 2025 Financial Results and Provides 2026 Financial Guidance

Rhea-AI Impact
(High)
Rhea-AI Sentiment
(Neutral)
Tags

Phathom Pharmaceuticals (Nasdaq: PHAT) reported Q4 2025 net revenue of $57.6M and full-year 2025 net revenue of $175.1M, a 217% increase versus 2024. The company completed a ~$130M equity offering, modified term debt (remaining principal ~$175M) and expects operating profitability beginning in Q3 2026.

Phathom reported FY 2025 net loss of $221.2M, cash and cash equivalents of $130.0M as of Dec 31, 2025, and provided 2026 guidance: net revenues $320–$345M, gross margin ~80%, and non-GAAP opex $235–$250M.

Loading...
Loading translation...

Positive

  • Revenue +217% FY 2025 versus FY 2024
  • Q4 net revenue of $57.6M
  • $122.2M net proceeds from January 2026 offering
  • Operating profitability expected beginning Q3 2026
  • 2026 guidance: net revenues of $320–$345M and gross margin ~80%

Negative

  • Full-year net loss $221.2M in 2025
  • Term loan remaining principal of $175M
  • Highest 2026 RIFA cash hold obligation estimated at $120M
  • Non-GAAP operating expense guidance of $235–$250M implies sustained high spending

News Market Reaction – PHAT

+10.06%
18 alerts
+10.06% News Effect
+6.5% Peak Tracked
-8.3% Trough Tracked
+$102M Valuation Impact
$1.12B Market Cap
0.4x Rel. Volume

On the day this news was published, PHAT gained 10.06%, reflecting a significant positive market reaction. Argus tracked a peak move of +6.5% during that session. Argus tracked a trough of -8.3% from its starting point during tracking. Our momentum scanner triggered 18 alerts that day, indicating notable trading interest and price volatility. This price movement added approximately $102M to the company's valuation, bringing the market cap to $1.12B at that time.

Data tracked by StockTitan Argus on the day of publication.

Key Figures

Q4 2025 net revenues: $57.6 million FY 2025 net revenues: $175.1 million Q4 2025 operating expenses: $55.9 million +5 more
8 metrics
Q4 2025 net revenues $57.6 million Fourth quarter 2025 net revenues vs $29.7 million in Q4 2024
FY 2025 net revenues $175.1 million Full year 2025 net revenues, a 217% increase from 2024
Q4 2025 operating expenses $55.9 million GAAP operating expenses in Q4 2025
Q4 2025 non-GAAP opex $50.3 million Q4 2025 operating expenses excluding stock-based compensation
Q4 2025 net loss $21.1 million GAAP net loss for the fourth quarter 2025
Cash & equivalents $130.0 million Cash and cash equivalents as of December 31, 2025
2026 revenue guidance $320–$345 million Full year 2026 net revenue guidance
2026 non-GAAP opex $235–$250 million 2026 non-GAAP operating expenses guidance (ex-stock-based compensation)

Market Reality Check

Price: $12.56 Vol: Volume 1,718,126 is 1.89x...
high vol
$12.56 Last Close
Volume Volume 1,718,126 is 1.89x the 20-day average of 910,808, indicating elevated trading interest. high
Technical Price $12.32 is trading above the 200-day MA at $11.57, reflecting an improved longer-term trend pre-news.

Peers on Argus

PHAT gained 6.12% on this earnings report, while key biotech peers showed mixed ...
1 Down

PHAT gained 6.12% on this earnings report, while key biotech peers showed mixed moves (e.g., QURE up 5.93%, IMNM down 0.67%, URGN down 0.58%). Momentum scans only flagged GERN moving down, supporting a stock-specific reaction rather than a sector-wide move.

Previous Earnings Reports

5 past events · Latest: Jan 07 (Positive)
Same Type Pattern 5 events
Date Event Sentiment Move Catalyst
Jan 07 Preliminary 2025 results Positive -13.7% Preliminary Q4/FY25 revenue and expense ranges with profitability outlook.
Oct 30 Q3 2025 earnings Positive -1.6% Q3 revenue growth, improved cash usage, and reiterated 2025 revenue guidance.
Aug 07 Q2 2025 earnings Positive +8.3% Strong Q2 revenue growth, guidance to $165–175M and 2026 profitability target.
May 01 Q1 2025 earnings Negative -21.7% Higher net loss and workforce reduction alongside early VOQUEZNA ramp.
Mar 06 FY 2024 results Positive -3.0% Strong 2024 VOQUEZNA launch metrics and revenue growth with ongoing losses.
Pattern Detected

Earnings-related news has often seen negative price reactions even when fundamentals improved, with 3 of the last 5 earnings updates selling off despite positive operating trends.

Recent Company History

Across the last five earnings updates from Mar 2025 through preliminary results on Jan 7, 2026, Phathom consistently highlighted rapid VOQUEZNA prescription growth, rising revenues, and a path toward operating profitability in 2026. However, shares frequently traded down on these announcements, including a -13.72% move on the January 2026 prelim release. Today’s detailed Q4/FY25 results and 2026 guidance confirm those trends with higher reported revenues, lower expenses, and clearer profitability timing, marking continuity rather than a strategic shift.

Historical Comparison

-6.3% avg move · Over the last five earnings-related releases, PHAT’s average move was -6.34%. Today’s +6.12% reactio...
earnings
-6.3%
Average Historical Move earnings

Over the last five earnings-related releases, PHAT’s average move was -6.34%. Today’s +6.12% reaction to the full Q4/FY25 results and 2026 guidance contrasts with that typical post-earnings weakness.

Earnings updates since early 2025 show a steady progression: rapid VOQUEZNA revenue growth, tightening operating expenses, and a consistent goal of achieving operating profitability in 2026, now reinforced with more detailed 2026 guidance.

Regulatory & Risk Context

Active S-3 Shelf
Shelf Active
Active S-3 Shelf Registration 2026-01-07

Phathom has an effective automatic shelf registration on Form S-3ASR dated Jan 7, 2026, allowing issuance of various securities over time. This shelf has already been used via two 424B5 prospectus supplements in January 2026, indicating capacity for further capital raises if management chooses.

Market Pulse Summary

The stock surged +10.1% in the session following this news. A strong positive reaction aligns with t...
Analysis

The stock surged +10.1% in the session following this news. A strong positive reaction aligns with the report’s combination of rapid revenue growth and tighter expense control. Shares rose 6.12% with volume at 1.89x average, contrasting with the historical average earnings move of -6.34%. Investors reacted to clearer 2026 guidance and reduced cash burn, while remaining mindful of ongoing net losses and an active S-3ASR shelf that has already supported recent equity financing.

Key Terms

non-gaap, phase 2, eosinophilic esophagitis, pre-funded warrants, +4 more
8 terms
non-gaap financial
"non-GAAP operating expenses of $50.3 million and net cash usage"
Non-GAAP refers to financial measures that companies use to show their earnings or performance without including certain expenses or income that are often added back to give a different picture. It matters because it can make a company's results look better or more favorable, but it may also hide important costs, so investors need to look at both GAAP (official rules) and non-GAAP numbers to get a full understanding.
phase 2 medical
"The Phase 2 pHalcon-EoE-201 trial evaluating VOQUEZNA in patients"
Phase 2 is the mid-stage clinical trial where a new drug or treatment is tested in a larger group of patients to see if it works and to keep checking safety after initial human testing. Think of it as a field test that proves whether a product actually delivers its promised benefit. Investors watch Phase 2 closely because its results strongly influence a medicine’s chances of reaching the market, the size of its potential sales, and the company’s valuation.
eosinophilic esophagitis medical
"trial evaluating VOQUEZNA in patients with Eosinophilic Esophagitis (EoE)"
A chronic allergic condition in which a type of white blood cell builds up in the tube that carries food from the mouth to the stomach, causing inflammation, difficulty swallowing and chest or throat pain; think of it as sticky residue narrowing a pipe. It matters to investors because prevalence, diagnostic rates and treatment options drive demand for drugs, tests and procedures, and clinical or regulatory news can quickly change revenue and valuation for healthcare companies working on therapies or diagnostics.
pre-funded warrants financial
"public offering of common stock and pre-funded warrants, resulting in gross proceeds"
Pre-funded warrants are financial instruments that give investors the right to purchase a company's stock at a set price, but with most or all of the purchase price paid upfront. They function like a coupon or gift card for stock, allowing investors to buy shares later at a fixed price, which can be beneficial if they want to avoid future price increases. This makes them important for investors seeking flexibility and certainty in their investment plans.
revenue interest financing agreement financial
"repayment obligations associated with its term loan and revenue interest financing agreement (RIFA)"
A revenue interest financing agreement is a deal where a company receives cash now in exchange for giving an investor a fixed percentage of future revenue until a set amount or time is reached. Think of it like selling a small slice of every sale to an investor instead of taking a traditional loan or issuing stock. Investors care because it affects future cash flow and returns—payments rise and fall with sales and don’t dilute ownership like equity.
gross-to-net financial
"Net revenues of $320–$345 million, which includes approximately $17–$20 million as result of the classification change described in the Explanatory Note belowGross- to-net of 55–59%"
Gross-to-net describes the difference between a product’s total billed sales (the “sticker” or list price) and the cash a company actually keeps after subtracting discounts, rebates, returns and other deductions. For investors it matters because large or growing deductions can make reported sales look strong on paper while actual revenue and profit are much smaller, similar to a store advertising high prices but taking many coupons at checkout.
gross margin financial
"Gross margin of approximately 80%Non-GAAP operating expenses"
Gross margin is the difference between how much money a company makes from selling its products and how much it costs to produce them, expressed as a percentage of sales. It shows how efficiently a company is turning sales into profit before other expenses like marketing or salaries. Higher gross margin means the company keeps more money from each sale, which is a good sign of financial health.
automatic shelf registration regulatory
"has filed an automatic shelf registration on Form S-3 that allows it to offer"
Automatic shelf registration is a process that allows companies to register securities with regulators in advance, so they can sell new shares or bonds quickly whenever market conditions are favorable. For investors, this means companies can raise money more efficiently, often leading to more timely investment opportunities. It helps ensure that companies can respond swiftly to financing needs without lengthy approval delays.

AI-generated analysis. Not financial advice.

  • Over 1.1 million total VOQUEZNA® prescriptions filled to date
  • $57.6 million in Q4 net revenues; $175.1 million in FY 2025 net revenues, a 217% increase from FY 2024
  • Q4 operating expenses of $55.9 million; non-GAAP operating expenses of $50.3 million and net cash usage of approximately $5.2 million, reflecting continued expense discipline
  • Strengthened financial position through $130 million equity offering and modification of term debt
  • Providing FY 2026 guidance; operating profitability expected beginning in Q3 2026 and for FY 2026
  • Management to host conference call today, February 26, 2026, at 8:00 a.m. EST

FLORHAM PARK, N.J., Feb. 26, 2026 (GLOBE NEWSWIRE) -- Phathom Pharmaceuticals, Inc. (Nasdaq: PHAT), a biopharmaceutical company focused on commercializing and developing novel treatments for gastrointestinal (GI) diseases, today reported financial results for the fourth quarter and full year ended December 31, 2025, and provided 2026 financial guidance.

“We are pleased with our continued growth throughout 2025, leveraging the efficiency of our GI-focused strategy,” said Steven Basta, President and Chief Executive Officer of Phathom. “Revenue increased significantly over the last three quarters. In the fourth quarter, we realigned our sales organization and enter 2026 with a stronger sales team and marketing initiatives designed to deepen engagement and increase prescribing for GERD across gastroenterologists.”

“Phathom exited 2025 with strong revenue growth and meaningful progress on expense discipline initiatives,” said Sanjeev Narula, Chief Financial and Business Officer of Phathom. “Following our January financing, we negotiated a modification to our term loan to reduce interest and extend maturity. We believe these steps provide us with an enhanced capital structure and financial flexibility as we position Phathom for anticipated operating profitability beginning in the third quarter 2026. We are executing with discipline to drive revenue growth and anticipate reaching cash flow positivity in 2027.”

Recent Business Highlights and Fourth Quarter and Full Year 2025 Results

VOQUEZNA Commercial Progress:

  • Phathom completed its sales force realignment in the fourth quarter. Phathom’s sales force is currently at >95% strength, having filled most of the open sales positions in recent weeks.
  • In the fourth quarter, Phathom recruited new marketing leadership and aligned marketing messages and activities to support the sales focus on writer depth and frequency among gastroenterologists.
  • More than 1.1 million total VOQUEZNA prescriptions have been filled as of February 13, 2026.
  • Approximately 273,000 VOQUEZNA prescriptions were filled in the fourth quarter, a 24% increase quarter over quarter. Covered prescriptions grew 21% during the fourth quarter and continue to be the primary driver of revenue.

EoE Clinical Trial Update:

  • The Phase 2 pHalcon-EoE-201 trial evaluating VOQUEZNA in patients with Eosinophilic Esophagitis (EoE) is actively enrolling as planned. Topline results are anticipated in 2027.

Strengthened Capital Structure and Financial Update:

  • In January 2026, Phathom completed an underwritten public offering of common stock and pre-funded warrants, resulting in gross proceeds of approximately $130 million and $122.2 million in net proceeds.
  • In February 2026, the Company modified the terms of its outstanding term debt facility, reducing overall debt outstanding, lowering its interest rate, and extending the maturity date to February 2029 with partial repayment beginning in 2028. Phathom reduced the remaining principal to $175 million outstanding and paid certain end-of-term fees and accrued paid-in-kind amounts under the original agreement.
  • As a result of the Company’s enhanced capital structure, including approximately $190 million of cash on hand following the term loan modification, Phathom believes it has sufficient resources, together with anticipated future cash flow from operations, to satisfy all liquidity covenants and repayment obligations associated with its term loan and revenue interest financing agreement (RIFA). Modification of the term debt facility extended the repayment obligation. RIFA cash hold covenants begin in October 2026 and adjust over time based on formulas related to royalty amounts paid to date. The Company anticipates that the highest cash hold obligation during 2026 will be approximately $120 million. Phathom expects to maintain cash balances above this level throughout 2026. Additional details are provided in the Company’s Annual Report on Form 10-K.

Fourth Quarter and Full Year 2025 Financial Results:

  • Revenue: Net revenues for the fourth quarter 2025 were $57.6 million, an increase of $27.9 million compared to $29.7 million for the fourth quarter 2024. Net revenues for the full year 2025 were $175.1 million, an increase of $119.8 million compared to $55.3 million in 2024.
  • Research and development (R&D) expenses: R&D expenses for the fourth quarter 2025 were $7.5 million, a decrease of $1.1 million compared to $8.6 million for fourth quarter 2024. R&D expenses for the full year 2025 were $32.8 million, a decrease of $1.3 million compared to $34.1 million in 2024.
  • Selling, general and administrative (SG&A) expenses: SG&A expenses for the fourth quarter 2025 were $48.4 million, a decrease of $28.3 million compared to $76.7 million for fourth quarter 2024. SG&A expenses for the full year 2025 were $279.7 million, a decrease of $11.0 million compared to $290.7 million in 2024. The decrease was primarily due to a reduction in commercial-related promotional expenses, personnel-related expenses, and third-party spend.
  • Operating expenses: Operating expenses for the fourth quarter 2025 were $55.9 million, compared to $85.3 million for the fourth quarter 2024 and $58.6 million during the third quarter 2025. The sequential decrease compared to the third quarter 2025 was attributable to cost savings associated with lower commercial promotional spend, lower personnel-related expenses, and lower third-party spend. Fourth quarter 2025 operating expense included a non-cash charge related to stock-based compensation of $5.6 million compared to $6.7 million for the fourth quarter 2024 and $9.3 million for the third quarter 2025. Non-GAAP operating expenses, which exclude stock-based compensation charges, for the fourth quarter 2025 were $50.3 million, compared to $78.6 million for the fourth quarter 2024 and $49.3 million during the third quarter 2025.

Operating expenses for the full year ended 2025 were $312.5 million, compared to $324.7 million for the full year ended 2024. For the year ended 2025, operating expense included a non-cash charge related to stock-based compensation of $28.7 million compared to $24.0 million for the full year ended 2024. Non-GAAP operating expenses, which exclude stock-based compensation charges, for the full year ended 2025 were $283.8 million, compared to $300.7 million for the full year ended 2024.

  • Net loss: Net loss for the fourth quarter 2025 was $21.1 million, compared to $74.5 million for the fourth quarter 2024. Non-GAAP adjusted net loss for the fourth quarter 2025 was $5.7 million compared to $56.4 million for the same period in 2024. Net loss for the year ended 2025 was $221.2 million, compared to $334.3 million for the full year ended 2024. Non-GAAP adjusted net loss for the year ended 2025 was $150.5 million compared to $262.3 million for the year ended 2024. These non-GAAP adjusted net loss amounts, as more fully described below under "Non-GAAP Financial Measures," exclude non-cash stock-based compensation charges, non-cash interest expense related to the accounting for our revenue interest financing liability, which are in excess of the actual interest owed, and interest expense related to the amortization of debt discount on our term loan. A reconciliation of the GAAP financial results to non-GAAP financial results is included in the tables below.
  • Cash and cash equivalents: As of December 31, 2025, cash and cash equivalents were $130.0 million. Net cash usage was approximately $5.2 million in the fourth quarter of 2025, representing a 64% improvement from net cash usage of approximately $14.0 million in the third quarter of 2025. Based on its current operating plan and projected product revenues, and the $122.2 million of net proceeds from the January 2026 offering, the Company believes these resources will be sufficient to fund operations and achieve operating profitability beginning in the third quarter 2026, excluding non-cash stock-based compensation.

2026 Financial Guidance

  • For the full year 2026, Phathom is providing the following financial guidance:
    • Net revenues of $320$345 million, which includes approximately $17$20 million as result of the classification change described in the Explanatory Note below
    • Gross- to-net of 55–59%
    • Gross margin of approximately 80%
    • Non-GAAP operating expenses, excluding stock-based compensation, of $235$250 million
    • Operating profitability, excluding stock-based compensation, expected beginning in the third quarter 2026 and for the full year 2026

Explanatory Note for 2026 Guidance:

  • Beginning January 1, 2026, the Company will include certain third-party charges in cost of goods sold instead of gross-to-net adjustments. The Company’s 2026 financial guidance reflects this update.

Conference Call and Webcast
Phathom will host a conference call and webcast to discuss its fourth quarter and full year 2025 financial results and business highlights today, February 26, 2026, at 8:00 a.m. EST. A live webcast will be available on the investors page of Phathom’s website under Events & Presentations. A replay of the webcast will be available following the completion of the call and will be archived for up to 90 days.

Non-GAAP Financial Measures
This press release includes financial results prepared in accordance with accounting principles generally accepted in the United States (GAAP), and also certain non-GAAP financial measures. In particular, Phathom has provided non-GAAP operating expense, adjusted net loss and adjusted net loss per share, adjusted to exclude the items below. Non-GAAP financial measures are not an alternative for financial measures prepared in accordance with GAAP. However, Phathom believes the presentation of non-GAAP adjusted operating expense, net loss and adjusted net loss per share, when viewed in conjunction with GAAP results, provides investors with a more meaningful understanding of ongoing operating performance. Non-GAAP operating expense excludes non-cash stock-based compensation, which is impacted by changes in the market price of common stock. Adjusted net loss and net loss per share exclude (i) non-cash stock-based compensation, (ii) interest expense related to the accounting for our revenue interest financing liability, which are in excess of the actual interest owed, and (iii) interest expense related to the amortization of debt discount on our term loan. Phathom does not provide a reconciliation of projected non-GAAP adjusted operating expense to GAAP operating expense due to the inherent difficulty in forecasting and quantifying non-cash stock-based compensation which is dependent on changes in the market price of common stock and necessary for such reconciliation.

Phathom believes the presentation of these non-GAAP financial measures provides useful information to management and investors regarding Phathom's results of operations. When GAAP financial measures are viewed in conjunction with these non-GAAP financial measures, investors are provided with a more meaningful understanding of Phathom's ongoing operating performance and are better able to compare Phathom's performance between periods. In addition, these non-GAAP financial measures are among those indicators Phathom uses as a basis for evaluating performance, and planning and forecasting future periods. These non-GAAP financial measures are not intended to be considered in isolation or as a substitute for GAAP financial measures. A reconciliation between these non-GAAP measures and the most directly comparable GAAP measures is provided later in this press release.

About Phathom Pharmaceuticals, Inc.
Phathom Pharmaceuticals is a biopharmaceutical company focused on the development and commercialization of novel treatments for gastrointestinal diseases. Phathom has in-licensed the exclusive rights to vonoprazan, a first-in-class potassium-competitive acid blocker (PCAB) for the U.S., Europe and Canada. Phathom currently markets vonoprazan in the United States as VOQUEZNA® (vonoprazan) tablets for the relief of heartburn associated with Non-Erosive GERD in adults, the healing and maintenance of healing of Erosive GERD in adults and relief of associated heartburn, and as part of VOQUEZNA® DUAL PAK® (vonoprazan tablets, amoxicillin capsules) and VOQUEZNA® TRIPLE PAK® (vonoprazan tablets, amoxicillin capsules, clarithromycin tablets) for the treatment of H. pylori infection in adults. For more information about Phathom, visit the company’s website at www.phathompharma.com and follow on LinkedIn and X.

Forward-Looking Statements
This press release contains forward-looking statements, including without limitation statements regarding: our planned commercialization efforts with respect to VOQUEZNA and our expectations as to potential operating results; our guidance and expectations regarding financial results for 2026, including revenues, operating expenses, gross-to-net and gross margin; our expectations and path for achieving operating profitability and cash flow positive operations and potential timing thereof; our views as to the impact of our financing and amendment of our term debt vehicle on our financial profile and flexibility; our belief in our ability to meet liquidity covenants and repayment obligations under the term debt and RIFA with existing cash and cash anticipated to be generated from operations; our development plans and potential timelines including our ability to report topline results from the pHalcon-EoE-201 trial in 2027; our business strategy, goals, mission and vision, including our goal to be a leader in GI; and our other expectations, forecasts and predictions as to future performance, results and likelihood of success. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including the risk that: we may not be able to successfully commercialize VOQUEZNA or to achieve operating results, revenues or growth at the levels we expect; the market opportunity for VOQUEZNA may be significantly smaller than our expectations; market acceptance for VOQUEZNA from healthcare professionals, patients, and payors in the indications for which it is approved may be significantly lower than we anticipate; we may encounter coverage, reimbursement, market access, or other issues in the course of our commercialization efforts that may negatively impact our efforts and results; the unmet need for new treatment options in GERD may not be as high as we anticipate; estimates of the number of patients with the disorders for which VOQUEZNA is approved, now or in the future, and our estimates of potential market size may not be accurate; our decisions as to where to allocate our resources and focus our efforts may not lead to the results we expect; we may not seek, achieve or maintain the patent and regulatory exclusivity we expect or that could be available to us and may encounter generic competition sooner than we anticipate; our results may be negatively impacted by the launch of other competitive products; we may experience adverse impact as the result of our dependence on third parties in connection with commercialization, product manufacturing, research and preclinical and clinical testing; we may be negatively impacted by regulatory developments or other governmental actions in the United States, including government healthcare reform; we may encounter unexpected adverse side effects or inadequate efficacy of VOQUEZNA that may limit or impair market acceptance or impair current or future development or regulatory approvals, or may result in recalls, withdrawals or product liability claims; we may not be able to obtain and maintain intellectual property protection important to our business; if we were to breach our license agreement with Takeda for vonoprazan, Takeda might take action, including termination, that would significantly impair our business; we may encounter issues with our ongoing or planned clinical trials, including slower than expected enrollment that affect timing or chances of success; we may receive negative or mixed results from our ongoing or future clinical trials that impact our business, goals or future opportunities; our operating expenses may be higher than we anticipate, including if we decide to engage in activities not currently in our plan or if we face unexpected, or higher than anticipated, expenses, including as the result of unexpected events such as litigation; depending on our operating results and activities, we may not achieve our financial guidance and we may not achieve profitability or cash flow positivity on the timelines we expect or at all; for the foregoing or other reasons, in the future, we may not have sufficient cash to fund our operations at the levels we expect or to meet our obligations under the term debt or RIFA or our other obligations or to enable us to achieve profit from operations; we may need to or decide to raise additional capital and we may not be able to do so on acceptable terms or at all; and any of the foregoing or other factors may negatively impact our ability to achieve our plans, goals, mission, vision and potential. For additional discussion of these and other risks, see the risk disclosure in our filings with the Securities and Exchange Commission (SEC), including our Annual Report on Form 10-K and any subsequent filings with the SEC. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and we undertake no obligation to revise or update this presentation to reflect events or circumstances after the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

MEDIA CONTACT
Nick Benedetto
1-877-742-8466
media@phathompharma.com

INVESTOR CONTACT
Eric Sciorilli
1-877-742-8466
ir@phathompharma.com

© 2026 Phathom Pharmaceuticals. All rights reserved.
VOQUEZNA, VOQUEZNA DUAL PAK, VOQUEZNA TRIPLE PAK, Phathom Pharmaceuticals, and their respective logos are registered trademarks of Phathom Pharmaceuticals, Inc.

Selected Condensed Balance Sheets
(in thousands)
(unaudited)

 
 December 31,
2025
 December 31,
2024
 
         
Cash and cash equivalents$129,972  $297,263  
Total assets$259,149  $378,318  
Total liabilities$697,318  $631,898  
Total stockholders' deficit$(438,169) $(253,580) 
 


Condensed Statements of Operations and Comprehensive Loss
(in thousands, except share and per share amounts)
(unaudited)
 
 Three Months Ended
December 31,
 Years Ended
December 31,
 
 2025
 2024
 2025
 2024
 
Product revenue, net$57,584  $29,664  $175,110  $55,252  
Cost of revenue 7,647   3,815   22,599   7,973  
Gross profit 49,937   25,849   152,511   47,279  
Operating expenses:                
Research and development 7,493   8,583   32,780   34,082  
Selling, general and administrative 48,372   76,683   279,717   290,664  
Total operating expenses 55,865   85,266   312,497   324,746  
Loss from operations (5,928)  (59,417)  (159,986)  (277,467) 
Other (expense) income:                
Interest income 1,204   3,510   7,044   15,158  
Interest expense (16,419)  (18,593)  (68,115)  (72,009) 
Other expense, net (5)  49   (190)  (8) 
Total other expense (15,220)  (15,034)  (61,261)  (56,859) 
Net loss and comprehensive loss$(21,148) $(74,451) $(221,247) $(334,326) 
Net loss per share, basic and diluted$(0.29) $(1.05) $(3.03) $(5.29) 
Weighted-average shares of common stock outstanding, basic and
diluted
 73,817,450   71,044,948   72,918,764   63,176,210  
 


Reconciliation of GAAP to Non-GAAP Financial Measures
(in thousands, except share and per share amounts)
(unaudited)

 
 Three Months Ended
December 31,
 Years Ended
December 31,
 
 2025
 2024
 2025
 2024
 
Reconciliation of GAAP to Non-GAAP adjusted net loss:                
GAAP net loss$(21,148) $(74,451) $(221,247) $(334,326) 
Stock-based compensation expense (A) 5,610   6,687   28,719   24,047  
Non-cash interest on revenue interest financing liability 8,994   10,759   39,052   45,771  
Interest expense related to amortization of debt discount 809   629   3,014   2,192  
Non-GAAP adjusted net loss$(5,735) $(56,376) $(150,462) $(262,316) 
Reconciliation of GAAP to Non-GAAP adjusted net loss per share —
basic and diluted:
                
GAAP net loss per share — basic and diluted$(0.29) $(1.05) $(3.03) $(5.29) 
Stock-based compensation expense (A) 0.08   0.10   0.39   0.37  
Non-cash interest on revenue interest financing liability 0.12   0.15   0.54   0.72  
Interest expense related to amortization of debt discount 0.01   0.01   0.04   0.03  
Non-GAAP net loss per share — basic and diluted$(0.08) $(0.79) $(2.06) $(4.17) 
Weighted-average shares of common stock outstanding, basic and
diluted
 73,817,450   71,044,948   72,918,764   63,176,210  
 

(A) Stock-based compensation consists of the following:

 Three Months Ended
December 31,
 Years Ended
December 31,
 
 2025
 2024
 2025
 2024
 
Research and development1,821 1,691 6,864 5,567 
Selling, general and administrative3,789 4,996 21,855 18,480 

FAQ

What were Phathom (PHAT) Q4 2025 revenues and full-year 2025 revenues?

Phathom reported $57.6 million in Q4 2025 revenue and $175.1 million for full-year 2025. According to the company, FY 2025 revenue increased 217% versus 2024, driven by VOQUEZNA prescription growth.

When does Phathom (PHAT) expect to become operating profitable in 2026?

Phathom expects operating profitability beginning in Q3 2026 and for the full year 2026 excluding stock-based compensation. According to the company, this reflects improved revenue and expense discipline.

What 2026 financial guidance did Phathom (PHAT) provide for revenue and margins?

Phathom guided to $320–$345 million in net revenues for 2026 with an approximate 80% gross margin. According to the company, guidance reflects a classification change for certain third-party charges.

How much cash and financing did Phathom (PHAT) secure in early 2026?

Phathom completed an equity offering with gross proceeds of about $130 million and reported $122.2 million net proceeds in January 2026. According to the company, it also modified term debt to enhance capital structure.

What is Phathom's (PHAT) outstanding debt and 2026 cash-hold concern?

After the term loan modification, remaining term loan principal is about $175 million, and the highest 2026 RIFA cash hold obligation is estimated at $120 million. According to the company, it expects to maintain cash above that level.

How did VOQUEZNA prescriptions and coverage change in Q4 2025 for Phathom (PHAT)?

Approximately 273,000 VOQUEZNA prescriptions were filled in Q4 2025, a 24% quarter-over-quarter increase, while covered prescriptions grew 21%. According to the company, these trends are primary drivers of revenue growth.
Phathom Pharmaceuticals, Inc.

NASDAQ:PHAT

PHAT Rankings

PHAT Latest News

PHAT Latest SEC Filings

PHAT Stock Data

1.06B
62.28M
Biotechnology
Pharmaceutical Preparations
Link
United States
FLORHAM PARK