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Phio Pharmaceuticals Corp. reports developments as a clinical-stage siRNA biopharmaceutical company advancing its proprietary INTASYL® gene-silencing technology for immuno-oncology. Company updates center on PH-762, an INTASYL compound designed to silence the PD-1 gene and evaluated as an intratumoral therapy for cutaneous squamous cell carcinoma, melanoma and Merkel cell carcinoma.
Recurring news themes include PH-762 clinical results, safety and pathology data, nonclinical toxicology work, cGMP clinical-supply manufacturing, regulatory-development steps, financial results, equity financing activity and investor presentations. Coverage also reflects the company's use of self-delivering RNAi technology intended to enhance immune-cell activity against tumor cells without specialized formulation or delivery systems.
Phio Pharmaceuticals (NASDAQ: PHIO) presented promising new data on its lead product candidate, PH-762, at the SITC 36th Annual Meeting. The study indicates that local administration of PH-762 in a hepatocarcinoma model not only inhibits the growth of treated tumors but also clears untreated distal tumors, suggesting a systemic immune response. Results showed that 80% of untreated tumors were completely cured, highlighting PH-762's potential as a new immunotherapy option with reduced systemic toxicity compared to traditional therapies. This data supports plans for a Phase 1 clinical trial in melanoma patients.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced its Q3 2021 financial results, reporting a net loss of $3.7 million or $0.28 per share, an increase from $2.3 million or $0.40 per share for Q3 2020. Cash and cash equivalents stood at $26.5 million as of September 30, 2021, expected to last until Q2 2023. The company aims to commence its first-in-human trial for PH-762 in Q1 2022 and expects to file a clinical trial application for PH-894 in H2 2022, showcasing the potential of its INTASYL technology in immuno-oncology.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced that new data indicates a systemic immune response can be triggered by its lead product candidate, PH-762, after local administration. These findings will be presented at the Society for Immunotherapy of Cancer (SITC) 36th Annual Meeting in Washington, D.C. from November 10-14, 2021. The relevant poster presentation is scheduled for November 12, 2021, at 7:00 am ET, showcasing potential advancements in immuno-oncology therapy.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced significant findings at the AACR-NCI-EORTC conference on October 7, 2021, regarding PH-894, its self-delivering RNAi compound targeting BRD4. The results indicate that PH-894 effectively silenced BRD4, enhancing T cell activation and tumor growth inhibition in vivo. This suggests PH-894 may serve as a promising immunotherapy option by reprogramming T cells. Phio is currently working on IND-enabling studies to advance PH-894 into clinical trials.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a biotechnology company specializing in immuno-oncology, announced two significant poster presentations at upcoming scientific conferences in October 2021. The first will occur at the AACR-NCI-EORTC Virtual International Conference from October 7-10, showcasing research on targeting BRD4 in T cells with self-delivering RNAi PH-894. The second presentation at the 8th Immunotherapy of Cancer Conference (ITOC8) on October 8-9 will focus on optimizing T lymphocytes for solid tumor therapy. For more details, visit their website.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) has announced promising results from a study showcased at the ESMO Congress 2021. The study demonstrated that the INTASYL technology could cure tumors and elicit durable systemic immunity in a preclinical model targeting PD-1 and BRD4. Specifically, 83% of the treated animals showed complete tumor response, even with low dosage therapy. This research highlights INTASYL's potential as a versatile immuno-oncology therapeutic platform, with further clinical trials anticipated to validate its efficacy.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) will participate in the H.C. Wainwright 23rd Annual Global Investment Conference, taking place virtually from September 13 to 15, 2021. Dr. Gerrit Dispersyn, President & CEO, will present on September 13 at 7:00 AM ET. A webcast of the presentation will be available, with replays accessible on the company's website for 90 days. Phio focuses on developing immuno-oncology therapeutics using its proprietary INTASYL platform, aimed at enhancing immune response against tumors.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) has announced that it will present new clinical study data at the ESMO Virtual Congress 2021 from September 16-21, 2021. The presentation will focus on dual targeting PD-1 and BRD4 using the company's proprietary INTASYL self-delivering RNAi platform, aiming to elicit persistent anti-tumor immunity following tumor resolution. The abstract number for this presentation is #4154. Archived details will be available on the Company's website in the Investors section.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) reported its financial results for Q2 2021, showing a net loss of $2.7 million. The company has $29.4 million in cash, sufficient to fund operations through Q2 2023. Phio is advancing its INTASYL™ platform, with promising preclinical data for its lead asset, PH-762, aimed at PD-1 in cancer treatment. Clinical trials are set to begin in 2022, with expected milestones including first-in-human studies for melanoma. R&D expenses increased to $1.7 million, reflecting expanded clinical preparation.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) will participate in a Fireside Chat with H.C. Wainwright on July 12, 2021, at 11 a.m. Eastern Time. The event aims to discuss the company’s advancements in immuno-oncology therapeutics utilizing its INTASYL™ RNAi platform, designed to boost immune responses against tumors. Interested listeners should register in advance to access the live audio. The webcast will be archived for 90 days on the company’s website. For more information on Phio's innovative therapies, visit their site.