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Phio Pharmaceuticals Corp. reports developments as a clinical-stage siRNA biopharmaceutical company advancing its proprietary INTASYL® gene-silencing technology for immuno-oncology. Company updates center on PH-762, an INTASYL compound designed to silence the PD-1 gene and evaluated as an intratumoral therapy for cutaneous squamous cell carcinoma, melanoma and Merkel cell carcinoma.
Recurring news themes include PH-762 clinical results, safety and pathology data, nonclinical toxicology work, cGMP clinical-supply manufacturing, regulatory-development steps, financial results, equity financing activity and investor presentations. Coverage also reflects the company's use of self-delivering RNAi technology intended to enhance immune-cell activity against tumor cells without specialized formulation or delivery systems.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced at the AACR 2020 Virtual Annual Meeting promising data from a study on PH-804, a TIGIT targeting INTASYL compound. The findings indicate significant tumor growth inhibition in a colorectal carcinoma model, showing PH-804's ability to silence TIGIT mRNA and enhance immune cell activation in the tumor microenvironment. This data supports the compound's potential as a viable alternative to anti-TIGIT antibodies.